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  1. Content type: Research article

    Postmarketing commitments are clinical studies that pharmaceutical companies agree to conduct at the time of FDA approval, but which are not required by statute or regulation. As FDA increasingly adopts a life...

    Authors: Joshua D. Wallach, Anita T. Luxkaranayagam, Sanket S. Dhruva, Jennifer E. Miller and Joseph S. Ross

    Citation: BMC Medicine 2019 17:117

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  2. Content type: Research article

    Pharmacogenetics (PGx) is currently implemented in hospitals to optimize therapy with high-risk drugs. However, many drugs with dosing recommendations from the Dutch Pharmacogenetics Working Group and the Clin...

    Authors: P. C. D. Bank, J. J. Swen and H. J. Guchelaar

    Citation: BMC Medicine 2019 17:110

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  3. Content type: Research article

    The Framingham risk models and pooled cohort equations (PCE) are widely used and advocated in guidelines for predicting 10-year risk of developing coronary heart disease (CHD) and cardiovascular disease (CVD) ...

    Authors: Johanna A. Damen, Romin Pajouheshnia, Pauline Heus, Karel G. M. Moons, Johannes B. Reitsma, Rob J. P. M. Scholten, Lotty Hooft and Thomas P. A. Debray

    Citation: BMC Medicine 2019 17:109

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  4. Content type: Research article

    Multimorbidity is an emerging public health priority. Physical activity (PA) is recommended as one of the main lifestyle behaviours, yet the benefits of PA for people with multimorbidity are unclear. We assess...

    Authors: Yogini V. Chudasama, Kamlesh K. Khunti, Francesco Zaccardi, Alex V. Rowlands, Thomas Yates, Clare L. Gillies, Melanie J. Davies and Nafeesa N. Dhalwani

    Citation: BMC Medicine 2019 17:108

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  5. Content type: Research article

    Infectious disease epidemics are a constant threat, and while we can strengthen preparedness in advance, inevitably, we will sometimes be caught unaware by novel outbreaks. To address the challenge of rapidly ...

    Authors: Louise Sigfrid, Catrin Moore, Alex P. Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke and Peter Horby

    Citation: BMC Medicine 2019 17:107

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  6. Content type: Research article

    Intratumoral immune infiltrates have manifested a robust prognostic signature in patients with hepatocellular carcinoma (HCC). We hypothesized that a novel tissue-related immune signature (TRIS) could improve ...

    Authors: Meng-Xin Tian, Wei-Ren Liu, Han Wang, Yu-Fu Zhou, Lei Jin, Xi-Fei Jiang, Chen-Yang Tao, Zheng Tang, Pei-Yun Zhou, Yuan Fang, Wei-Feng Qu, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou…

    Citation: BMC Medicine 2019 17:106

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  7. Content type: Research article

    News stories represent an important source of information. We aimed to evaluate the impact of “spin” (i.e., misrepresentation of study results) in health news stories reporting studies of pharmacologic treatme...

    Authors: Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer and Philippe Ravaud

    Citation: BMC Medicine 2019 17:105

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    The Correction to this article has been published in BMC Medicine 2019 17:147

  8. Content type: Correspondence

    Reducing maternal mortality is a key focus of development strategies and one of the indicators used to measure progress towards achieving the Sustainable Development Goals. In the absence of medical certificat...

    Authors: Ian D. Riley, Riley H. Hazard, Rohina Joshi, Hafizur Rahman Chowdhury and Alan D. Lopez

    Citation: BMC Medicine 2019 17:104

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  9. Content type: Research article

    Accurate and timely diagnosis of malaria is essential for disease management and surveillance. Thin and thick blood smear microscopy and malaria rapid diagnostic tests (RDTs) are standard malaria diagnostics, ...

    Authors: Annelies Post, Berenger Kaboré, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast and Andre J. van der Ven

    Citation: BMC Medicine 2019 17:103

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  10. Content type: Software

    Verbal autopsy is an increasingly important methodology for assigning causes to otherwise uncertified deaths, which amount to around 50% of global mortality and cause much uncertainty for health planning. The ...

    Authors: Peter Byass, Laith Hussain-Alkhateeb, Lucia D’Ambruoso, Samuel Clark, Justine Davies, Edward Fottrell, Jon Bird, Chodziwadziwa Kabudula, Stephen Tollman, Kathleen Kahn, Linus Schiöler and Max Petzold

    Citation: BMC Medicine 2019 17:102

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  11. Content type: Research article

    Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especi...

    Authors: Ymkje Anna de Vries, Ali Al-Hamzawi, Jordi Alonso, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, José Miguel Caldas-de-Almeida, Alfredo H. Cia, Giovanni De Girolamo, Rumyana V. Dinolova, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep Maria Haro, Chiyi Hu, Elie G. Karam…

    Citation: BMC Medicine 2019 17:101

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  12. Content type: Research article

    Prediabetes appears to be increasing worldwide. This study examined the incidence of prediabetes among immigrants to Canada of different ethnic origins and the age at which ethnic differences emerged.

    Authors: Ghazal S. Fazli, Rahim Moineddin, Arlene S. Bierman and Gillian L. Booth

    Citation: BMC Medicine 2019 17:100

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  13. Content type: Research article

    School neighborhood food environment is recognized as an important contributor to childhood obesity; however, large-scale and longitudinal studies remain limited. This study aimed to examine this association a...

    Authors: Peng Jia, Hong Xue, Xi Cheng and Youfa Wang

    Citation: BMC Medicine 2019 17:99

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  14. Content type: Correspondence

    We thank Daly-Smith et al. for taking the time to read the results of our pilot research study, describing it as an important and welcome contribution. Nonetheless, the authors argue six points against our con...

    Authors: Ross A. Chesham, Josephine N. Booth, Emma L. Sweeney, Gemma C. Ryde, Trish Gorely, Naomi E. Brooks and Colin N. Moran

    Citation: BMC Medicine 2019 17:97

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    The original article was published in BMC Medicine 2019 17:96

  15. Content type: Correspondence

    A recent pilot study by Chesham et al. in BMC Medicine established some initial effects of the Daily Mile™ using a quasi-experimental repeated measures design, with valid and reliable outcome assessments for mode...

    Authors: Andy Daly-Smith, Jade L. Morris, Matthew Hobbs and Jim McKenna

    Citation: BMC Medicine 2019 17:96

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    The Correspondence to this article has been published in BMC Medicine 2019 17:97

    The original article was published in BMC Medicine 2018 16:64

  16. Content type: Research article

    Acute kidney injury (AKI) is a recognized complication of pediatric severe malaria, but its long-term consequences are unknown.

    Authors: Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Richard Idro, John M. Ssenkusu, Dibyadyuti Datta, James S. Hodges, Catherine Morgan and Chandy C. John

    Citation: BMC Medicine 2019 17:98

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  17. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is a common condition that progresses in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Here we used healthcare records of 18 m...

    Authors: Myriam Alexander, A. Katrina Loomis, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Dawn M. Waterworth, Stuart Kendrick, Naveed Sattar and William Alazawi

    Citation: BMC Medicine 2019 17:95

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    The Commentary to this article has been published in BMC Medicine 2019 17:123

  18. Content type: Research article

    In recent years, we witnessed a resurgence of measles even in countries where, according to WHO guidelines, elimination should have already been achieved. In high-income countries, the raise of anti-vaccinatio...

    Authors: Filippo Trentini, Piero Poletti, Alessia Melegaro and Stefano Merler

    Citation: BMC Medicine 2019 17:86

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  19. Content type: Research article

    Misleading news claims can be detrimental to public health. We aimed to improve the alignment between causal claims and evidence, without losing news interest (counter to assumptions that news is not intereste...

    Authors: Rachel C. Adams, Aimée Challenger, Luke Bratton, Jacky Boivin, Lewis Bott, Georgina Powell, Andy Williams, Christopher D. Chambers and Petroc Sumner

    Citation: BMC Medicine 2019 17:91

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  20. Content type: Research article

    Frailty index (FI) is a well-established predictor of all-cause mortality, but less is known for cause-specific mortality and whether familial effects influence the associations. Middle-aged individuals are al...

    Authors: Xia Li, Alexander Ploner, Ida K. Karlsson, Xingrong Liu, Patrik K. E. Magnusson, Nancy L. Pedersen, Sara Hägg and Juulia Jylhävä

    Citation: BMC Medicine 2019 17:94

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  21. Content type: Research article

    The World Health Organization (WHO) International Classification of Diseases and Related Health Problems (ICD) is used globally by 194 WHO member nations. It is used for assigning clinical diagnoses, providing...

    Authors: Angélica M. Claudino, Kathleen M. Pike, Phillipa Hay, Jared W. Keeley, Spencer C. Evans, Tahilia J. Rebello, Rachel Bryant-Waugh, Yunfei Dai, Min Zhao, Chihiro Matsumoto, Cecile Rausch Herscovici, Blanca Mellor-Marsá, Anne-Claire Stona, Cary S. Kogan, Howard F. Andrews, Palmiero Monteleone…

    Citation: BMC Medicine 2019 17:93

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  22. Content type: Research article

    Understanding where adults with diabetes in India are lost in the diabetes care cascade is essential for the design of targeted health interventions and to monitor progress in health system performance for man...

    Authors: Jonas Prenissl, Lindsay M. Jaacks, Viswanathan Mohan, Jennifer Manne-Goehler, Justine I. Davies, Ashish Awasthi, Anne Christine Bischops, Rifat Atun, Till Bärnighausen, Sebastian Vollmer and Pascal Geldsetzer

    Citation: BMC Medicine 2019 17:92

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  23. Content type: Research article

    In Burkina Faso, facility-based caesarean delivery rates have markedly increased since the national subsidy policy for deliveries and emergency obstetric care was implemented in 2006. Effective and safe strate...

    Authors: Charles Kaboré, Valéry Ridde, Nils Chaillet, Fadima Yaya Bocoum, Ana Pilar Betrán and Alexandre Dumont

    Citation: BMC Medicine 2019 17:87

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  24. Content type: Research article

    Copeptin is the stable surrogate marker of vasopressin (VP), which is released in response to elevated plasma osmolality or low blood pressure. Elevated plasma copeptin levels are associated with higher risk o...

    Authors: Ilaria Barchetta, Sofia Enhörning, Flavia Agata Cimini, Danila Capoccia, Caterina Chiappetta, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Olle Melander and Maria Gisella Cavallo

    Citation: BMC Medicine 2019 17:85

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  25. Content type: Correspondence

    It is critically important to conduct research on stigmatized conditions, to include marginalized groups that experience stigma, and to develop interventions to reduce stigma. However, such research is ethical...

    Authors: Joseph Millum, Megan Campbell, Florencia Luna, Arianne Malekzadeh and Quarraisha Abdool Karim

    Citation: BMC Medicine 2019 17:84

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  26. Content type: Research article

    Brazil’s Estratégia Saúde da Família (ESF) is one of the largest and most robustly evaluated primary healthcare programmes of the world, but it could be affected by fiscal austerity measures and by the possible e...

    Authors: Davide Rasella, Thomas Hone, Luis Eugenio de Souza, Renato Tasca, Sanjay Basu and Christopher Millett

    Citation: BMC Medicine 2019 17:82

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  27. Content type: Research article

    Resistant hypertension is independently associated with an increased risk of death in the general hypertensive population. We assessed whether resistant hypertension is an independent predictor of all-cause mo...

    Authors: Anna Solini, Giuseppe Penno, Emanuela Orsi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Olga Lamacchia, Marco G. Baroni, Antonio Nicolucci and Giuseppe Pugliese

    Citation: BMC Medicine 2019 17:83

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  28. Content type: Research article

    Mathematical transmission models are increasingly used to guide public health interventions for infectious diseases, particularly in the context of emerging pathogens; however, the contribution of modeling to ...

    Authors: Anna Maria Niewiadomska, Bamini Jayabalasingham, Jessica C. Seidman, Lander Willem, Bryan Grenfell, David Spiro and Cecile Viboud

    Citation: BMC Medicine 2019 17:81

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  29. Content type: Research article

    Ultra-processed food (UPF) consumption has increased over the last decades in Westernized countries. Our objective was to investigate for the first time the association between the proportion of UPF (%UPF) in ...

    Authors: Moufidath Adjibade, Chantal Julia, Benjamin Allès, Mathilde Touvier, Cédric Lemogne, Bernard Srour, Serge Hercberg, Pilar Galan, Karen E. Assmann and Emmanuelle Kesse-Guyot

    Citation: BMC Medicine 2019 17:78

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  30. Content type: Research article

    It is unclear what to do when people with type 2 diabetes have had no or a limited glycemic response to a recently introduced medication. Intra-individual HbA1c variability can obscure true response. Some guid...

    Authors: Andrew P. McGovern, John M. Dennis, Beverley M. Shields, Andrew T. Hattersley, Ewan R. Pearson and Angus G. Jones

    Citation: BMC Medicine 2019 17:79

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  31. Content type: Research article

    The uterine environment may influence telomere length at birth, which is essential for cellular function, aging, and disease susceptibility over the lifespan. However, little is known about the impact of toxic...

    Authors: Maria Herlin, Karin Broberg, Annachiara Malin Igra, Huiqi Li, Florencia Harari and Marie Vahter

    Citation: BMC Medicine 2019 17:77

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  32. Content type: Research article

    Multimorbidity is associated with higher mortality, but the relationship with cancer and cardiovascular mortality is unclear. The influence of demographics and type of condition on the relationship of multimor...

    Authors: Bhautesh Dinesh Jani, Peter Hanlon, Barbara I. Nicholl, Ross McQueenie, Katie I. Gallacher, Duncan Lee and Frances S. Mair

    Citation: BMC Medicine 2019 17:74

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  33. Content type: Research article

    Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the h...

    Authors: Vladeta Ajdacic-Gross, Margot Mutsch, Stephanie Rodgers, Anja Tesic, Mario Müller, Erich Seifritz, En-Young N. Wagner, Roland von Känel, Markus A. Landolt, Nina Steinemann, Viktor von Wyl, Enrique Castelao, Marie-Pierre F. Strippoli, Jennifer Glaus, Caroline Vandeleur, Pedro M. Marques-Vidal…

    Citation: BMC Medicine 2019 17:75

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  34. Content type: Research article

    Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain the international normalised ratio (INR) within a therapeutic range can be challenging. In a previous trial, we s...

    Authors: Andrea L. Jorgensen, Clare Prince, Gail Fitzgerald, Anita Hanson, Jennifer Downing, Julia Reynolds, J. Eunice Zhang, Ana Alfirevic and Munir Pirmohamed

    Citation: BMC Medicine 2019 17:76

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  35. Content type: Research article

    Risk prediction for patients with suspected coronary artery disease is complex due to the common occurrence of prior cardiovascular disease and extensive risk modification in primary care. Numerous markers hav...

    Authors: Dipak Kotecha, Marcus D. Flather, Dan Atar, Peter Collins, John Pepper, Elizabeth Jenkins, Christopher M. Reid and David Eccleston

    Citation: BMC Medicine 2019 17:72

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  36. Content type: Research article

    Peer support can enable patient engagement with healthcare services, particularly for marginalised populations. In this randomised controlled trial, the efficacy of a peer support intervention at promoting suc...

    Authors: Helen R. Stagg, Julian Surey, Marie Francis, Jennifer MacLellan, Graham R. Foster, André Charlett and Ibrahim Abubakar

    Citation: BMC Medicine 2019 17:71

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  37. Content type: Guideline

    There is a pressing need to understand better the extent and distribution of antimicrobial resistance on a global scale, to inform development of effective interventions. Collation of datasets for meta-analysi...

    Authors: Paul Turner, Andrew Fox-Lewis, Poojan Shrestha, David A. B. Dance, Tri Wangrangsimakul, Tomas-Paul Cusack, Clare L. Ling, Jill Hopkins, Tamalee Roberts, Direk Limmathurotsakul, Ben S. Cooper, Susanna Dunachie, Catrin E. Moore, Christiane Dolecek, H. Rogier van Doorn, Philippe J. Guerin…

    Citation: BMC Medicine 2019 17:70

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  38. Content type: Research article

    The most prevalent neglected tropical diseases are treated through blanket drug distribution that is reliant on lay community medicine distributors (CMDs). Yet, treatment rates achieved by CMDs vary widely and...

    Authors: Goylette F. Chami, Narcis B. Kabatereine and Edridah M. Tukahebwa

    Citation: BMC Medicine 2019 17:69

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  39. Content type: Forum

    Blockchain is a shared distributed digital ledger technology that can better facilitate data management, provenance and security, and has the potential to transform healthcare. Importantly, blockchain represen...

    Authors: Tim K. Mackey, Tsung-Ting Kuo, Basker Gummadi, Kevin A. Clauson, George Church, Dennis Grishin, Kamal Obbad, Robert Barkovich and Maria Palombini

    Citation: BMC Medicine 2019 17:68

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  40. Content type: Research article

    Statins may prevent recurrent ischemic events after ischemic stroke. Determining which statin to use remains controversial. We aimed to summarize the evidence for the use of statins in secondary prevention for...

    Authors: Irene Tramacere, Giorgio B. Boncoraglio, Rita Banzi, Cinzia Del Giovane, Koren H. Kwag, Alessandro Squizzato and Lorenzo Moja

    Citation: BMC Medicine 2019 17:67

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  41. Content type: Research article

    Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based stud...

    Authors: Lei Huang, Yesilda Balavarca, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Vesna Zadnik, Maja Primic-Žakelj, Margit Mägi, Robert Grützmann, Marc G. Besselink, Petra Schrotz-King, Hermann Brenner and Lina Jansen

    Citation: BMC Medicine 2019 17:66

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  42. Content type: Research article

    Studies have shown that more than half of patients with advanced progressive diseases approaching the end-of-life report pain and that pain relief for these patients is poorest at home compared to other care s...

    Authors: Yousuf ElMokhallalati, Natalie Woodhouse, Tracey Farragher and Michael I. Bennett

    Citation: BMC Medicine 2019 17:50

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  43. Content type: Research article

    Depression symptom questionnaires are commonly used to assess symptom severity and as screening tools to identify patients who may have depression. They are not designed to ascertain diagnostic status and, bas...

    Authors: Brooke Levis, Xin Wei Yan, Chen He, Ying Sun, Andrea Benedetti and Brett D. Thombs

    Citation: BMC Medicine 2019 17:65

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  44. Content type: Review

    The growing body of evidence indicating the heterogeneity of Alzheimer’s disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy, suggest that the development of a single ma...

    Authors: Mirna Safieh, Amos D. Korczyn and Daniel M. Michaelson

    Citation: BMC Medicine 2019 17:64

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  45. Content type: Research article

    The consumption of alcohol increases the risk of drinkers harming others. The extent of alcohol’s morbidity and mortality harms to others in Germany in 2014 was estimated for (1) fetal alcohol syndrome (FAS) o...

    Authors: Ludwig Kraus, Nicki-Nils Seitz, Kevin D. Shield, Gerrit Gmel and Jürgen Rehm

    Citation: BMC Medicine 2019 17:59

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