Skip to main content

Articles

Page 47 of 86

  1. Recently, a new algorithm for automatic computer certification of verbal autopsy data named InSilicoVA was published. The authors presented their algorithm as a statistical method and assessed its performance ...

    Authors: Abraham D. Flaxman, Jonathan C. Joseph, Christopher J. L. Murray, Ian Douglas Riley and Alan D. Lopez
    Citation: BMC Medicine 2018 16:56

    The Correspondence to this article has been published in BMC Medicine 2020 18:73

    The Correspondence to this article has been published in BMC Medicine 2020 18:69

  2. Ethnic minority service users with schizophrenia and schizoaffective disorders may experience inequalities in care. There have been no recent studies assessing access to evidence-based treatments for psychosis...

    Authors: Jayati Das-Munshi, Dinesh Bhugra and Mike J. Crawford
    Citation: BMC Medicine 2018 16:55
  3. Autonomic dysreflexia is a severe and potentially life-threatening condition in patients with spinal cord injury, as it can lead to myocardial ischemia, brain hemorrhage, or even death. Urodynamic investigatio...

    Authors: Matthias Walter, Stephanie C. Knüpfer, Jacquelyn J. Cragg, Lorenz Leitner, Marc P. Schneider, Ulrich Mehnert, Andrei V. Krassioukov, Martin Schubert, Armin Curt and Thomas M. Kessler
    Citation: BMC Medicine 2018 16:53
  4. Gold mines represent a potential hotspot for Mycobacterium tuberculosis (Mtb) transmission and may be exacerbating the tuberculosis (TB) epidemic in South Africa. However, the presence of multiple factors complic...

    Authors: Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff and Bradley G. Wagner
    Citation: BMC Medicine 2018 16:52

    The Correction to this article has been published in BMC Medicine 2018 16:242

  5. Despite the gender parity existing in medical schools for over three decades, women remain underrepresented in academic medical centers, particularly in senior ranks and in leadership roles. This has consequen...

    Authors: Reena Pattani, Christine Marquez, Camellia Dinyarian, Malika Sharma, Julie Bain, Julia E. Moore and Sharon E. Straus
    Citation: BMC Medicine 2018 16:48
  6. While the heterogeniety of pain progression has been studied in chronic diseases, the extent to which patterns of pain progression among people in general as well as across different diseases affect social, ci...

    Authors: Richard J. E. James, David A. Walsh and Eamonn Ferguson
    Citation: BMC Medicine 2018 16:51
  7. Meat is an important source of high-quality protein and vitamin B but also has a relatively high content of saturated and trans fatty acids. Although protein and vitamin B intake seems to protect people from func...

    Authors: Ellen A. Struijk, José R. Banegas, Fernando Rodríguez-Artalejo and Esther Lopez-Garcia
    Citation: BMC Medicine 2018 16:50
  8. In November 2016, the Dutch Health Council recommended hepatitis B (HBV) screening for first-generation immigrants from HBV endemic countries. However, these communities show relatively low attendance rates fo...

    Authors: Nora Hamdiui, Mart L. Stein, Aura Timen, Danielle Timmermans, Albert Wong, Maria E. T. C. van den Muijsenbergh and Jim E. van Steenbergen
    Citation: BMC Medicine 2018 16:47
  9. Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of predisposing factors and the natural history i...

    Authors: Conor Duncan Tweed, Genevieve Helen Wills, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Cheryl E. Louw, Timothy D. McHugh, Carl Mendel, Sarah Meredith, Lerato Mohapi, Michael E. Murphy, Stephen Murray, Sara Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha Singh…
    Citation: BMC Medicine 2018 16:46
  10. The U.S. Food and Drug Administration (FDA) often approves new drugs based on trials that use surrogate markers for endpoints, which involve certain trade-offs and may risk making erroneous inferences about th...

    Authors: Joshua D. Wallach, Oriana Ciani, Alison M. Pease, Gregg S. Gonsalves, Harlan M. Krumholz, Rod S. Taylor and Joseph S. Ross
    Citation: BMC Medicine 2018 16:45
  11. Insufficient sleep duration and obstructive sleep apnea, two common causes of sleep deficiency in adults, can result in excessive sleepiness, a well-recognized cause of motor vehicle crashes, although their co...

    Authors: Daniel J. Gottlieb, Jeffrey M. Ellenbogen, Matt T. Bianchi and Charles A. Czeisler
    Citation: BMC Medicine 2018 16:44
  12. Refugees may have an increased vulnerability to infectious diseases, and the consequences of an outbreak are more severe in a refugee camp. When an outbreak is suspected, access to clinical information is crit...

    Authors: Amanda M. Rojek, Kassiani Gkolfinopoulou, Apostolos Veizis, Angeliki Lambrou, Lyndsey Castle, Theano Georgakopoulou, Karl Blanchet, Takis Panagiotopoulos and Peter W. Horby
    Citation: BMC Medicine 2018 16:43
  13. An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to ...

    Authors: Linden Disney-Hogg, Alex J. Cornish, Amit Sud, Philip J. Law, Ben Kinnersley, Daniel I. Jacobs, Quinn T. Ostrom, Karim Labreche, Jeanette E. Eckel-Passow, Georgina N. Armstrong, Elizabeth B. Claus, Dora Il’yasova, Joellen Schildkraut, Jill S. Barnholtz-Sloan, Sara H. Olson, Jonine L. Bernstein…
    Citation: BMC Medicine 2018 16:42
  14. Clusterin, also known as apolipoprotein J (apoJ), is one of the most abundantly expressed apolipoproteins in the brain after apolipoprotein E (apoE). Like the ε4 allele of the apolipoprotein E gene (APOE), the cl...

    Authors: Liv Tybjærg Nordestgaard, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G. Nordestgaard and Ruth Frikke-Schmidt
    Citation: BMC Medicine 2018 16:39
  15. Since 2015, Europe has been facing an unprecedented arrival of refugees and migrants: more than one million people entered via land and sea routes. During their travels, refugees and migrants often face harsh ...

    Authors: Jihane Ben Farhat, Karl Blanchet, Pia Juul Bjertrup, Apostolos Veizis, Clément Perrin, Rebecca M. Coulborn, Philippe Mayaud and Sandra Cohuet
    Citation: BMC Medicine 2018 16:40
  16. Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomiz...

    Authors: Jannike Øyen, Ingrid Kvestad, Lisa Kolden Midtbø, Ingvild Eide Graff, Mari Hysing, Kjell Morten Stormark, Maria Wik Markhus, Valborg Baste, Livar Frøyland, Berthold Koletzko, Hans Demmelmair, Lisbeth Dahl, Øyvind Lie and Marian Kjellevold
    Citation: BMC Medicine 2018 16:41
  17. Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of sur...

    Authors: A. Aramburo, Jim Todd, Elizabeth C. George, Sarah Kiguli, Peter Olupot-Olupot, Robert O. Opoka, Charles Engoru, Samuel O. Akech, Richard Nyeko, George Mtove, Diana M. Gibb, Abdel G. Babiker and Kathryn Maitland
    Citation: BMC Medicine 2018 16:37
  18. Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age gr...

    Authors: Carol Coupland, Trevor Hill, Richard Morriss, Michael Moore, Antony Arthur and Julia Hippisley-Cox
    Citation: BMC Medicine 2018 16:36
  19. The original article [1] contains a major error whereby all rates in Table 2 are mistakenly presented as 50% of their true values; this error was caused by a miscalculation in annualising the original values t...

    Authors: Matthew J. Spittal, David M. Studdert, Ron Paterson and Marie M. Bismark
    Citation: BMC Medicine 2018 16:38

    The original article was published in BMC Medicine 2016 14:198

  20. Acute symptomatic seizures and febrile seizures are common in children admitted to hospitals in Africa and may be markers of brain dysfunction. They may be associated with behavioural and emotional problems, b...

    Authors: Symon M. Kariuki, Amina Abubakar, Martha Kombe, Michael Kazungu, Rachael Odhiambo, Alan Stein and Charles R. J. C. Newton
    Citation: BMC Medicine 2018 16:35
  21. External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary dise...

    Authors: Beniamino Guerra, Sarah R. Haile, Bernd Lamprecht, Ana S. Ramírez, Pablo Martinez-Camblor, Bernhard Kaiser, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristóbal Esteban-González, Juan J. Soler-Cataluña, Juan P. de-Torres, Marc Miravitlles, Bartolome R. Celli, Jose M. Marin, Gerben ter Riet…
    Citation: BMC Medicine 2018 16:33
  22. There is increasing focus on the strength of primary health care systems in low and middle-income countries (LMIC). There are important roles for higher quality district hospital care within these systems. The...

    Authors: Mike English, Paul Mwaniki, Thomas Julius, Mercy Chepkirui, David Gathara, Paul O. Ouma, Peter Cherutich, Emelda A. Okiro and Robert W. Snow
    Citation: BMC Medicine 2018 16:32
  23. The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer.

    Authors: V. J. Gnanapragasam, O. Bratt, K. Muir, L. S. Lee, H. H. Huang, P. Stattin and A. Lophatananon
    Citation: BMC Medicine 2018 16:31
  24. Despite long-lasting HIV replication control, a significant proportion of elite controller (EC) patients may experience CD4 T-cell loss. Discovering perturbations in immunological parameters could help our und...

    Authors: José M. Benito, María C. Ortiz, Agathe León, Luis A. Sarabia, José M. Ligos, María Montoya, Marcial Garcia, Ezequiel Ruiz-Mateos, Rosario Palacios, Alfonso Cabello, Clara Restrepo, Carmen Rodriguez, Jorge del Romero, Manuel Leal, María A. Muñoz-Fernández, José Alcamí…
    Citation: BMC Medicine 2018 16:30
  25. Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are of...

    Authors: Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap and Thomas Jaki
    Citation: BMC Medicine 2018 16:29
  26. Depression is viewed as a major and increasing public health issue, as it causes high distress in the people experiencing it and considerable financial costs to society. Efforts are being made to reduce this b...

    Authors: Anna Fernández, Juan M. Mendive, Sonia Conejo-Cerón, Patricia Moreno-Peral, Michael King, Irwin Nazareth, Carlos Martín-Pérez, Carmen Fernández-Alonso, Antonina Rodríguez-Bayón, Jose Maria Aiarzaguena, Carmen Montón-Franco, Antoni Serrano-Blanco, Inmaculada Ibañez-Casas, Emiliano Rodríguez-Sánchez, Luis Salvador-Carulla, Paola Bully Garay…
    Citation: BMC Medicine 2018 16:28
  27. Multidrug-resistant tuberculosis (MDR-TB) is a growing concern in meeting global targets for TB control. In high-income low-TB-incidence countries, a disproportionate number of MDR-TB cases occur in migrant (f...

    Authors: Laura B. Nellums, Kieran Rustage, Sally Hargreaves and Jon S. Friedland
    Citation: BMC Medicine 2018 16:27
  28. The ability to reproduce experiments is a defining principle of science. Reproducibility of clinical research has received relatively little scientific attention. However, it is important as it may inform clin...

    Authors: Daniel J. Niven, T. Jared McCormick, Sharon E. Straus, Brenda R. Hemmelgarn, Lianne Jeffs, Tavish R. M. Barnes and Henry T. Stelfox
    Citation: BMC Medicine 2018 16:26
  29. Adult-onset, or type II diabetes mellitus (T2DM) has a complex genetic architecture, from hundreds of genes with low penetrance, common susceptibility variants (e.g., TCF7L2), to a set of more than ten genes that...

    Authors: Leslie G. Biesecker
    Citation: BMC Medicine 2018 16:25

    The original article was published in BMC Medicine 2017 15:213

  30. Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent. We aimed to investigate the as...

    Authors: Simone Mocellin, Saveria Tropea, Clara Benna and Carlo Riccardo Rossi
    Citation: BMC Medicine 2018 16:20
  31. The therapeutic approach for the second-line treatment of patients with advanced non-small cell lung cancer (NSCLC) without actionable mutations has been revolutionized by the recent approval of new effective ...

    Authors: Alessandro Morabito
    Citation: BMC Medicine 2018 16:24

    The original article was published in BMC Medicine 2017 15:193

  32. Primary care provides the foundation for most modern health-care systems, and in the interests of equity, it should be resourced according to local need. We aimed to describe spatially the burden of chronic co...

    Authors: Evangelos Kontopantelis, Mamas A. Mamas, Harm van Marwijk, Andrew M. Ryan, Peter Bower, Bruce Guthrie and Tim Doran
    Citation: BMC Medicine 2018 16:19
  33. Comparisons of clinical trial findings in systematic reviews can be hindered by the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to patients might be underreported. A core ou...

    Authors: Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A. F. Jansen, Denis O’Mahony, Nicolas Rodondi and Anne Spinewine
    Citation: BMC Medicine 2018 16:21
  34. Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth the adrenals are essential for neonate salt retention...

    Authors: Zoe C. Johnston, Michelle Bellingham, Panagiotis Filis, Ugo Soffientini, Denise Hough, Siladitya Bhattacharya, Marc Simard, Geoffrey L. Hammond, Peter King, Peter J. O’Shaughnessy and Paul A. Fowler
    Citation: BMC Medicine 2018 16:23
  35. In sub-Saharan Africa, where ~ 25 million individuals are infected with HIV and transmission is predominantly heterosexual, there is substantial geographic variation in the severity of epidemics. This variatio...

    Authors: Laurence Palk and Sally Blower
    Citation: BMC Medicine 2018 16:22
  36. The seven-valent pneumococcal conjugate vaccine (PCV) was introduced in England in September 2006, changing to the 13-valent vaccine in April 2010. PCV impact on invasive pneumococcal disease (IPD) has been ex...

    Authors: Dominic Thorrington, Nick Andrews, Julia Stowe, Elizabeth Miller and Albert Jan van Hoek
    Citation: BMC Medicine 2018 16:13
  37. Women who experience menopause are at higher cardiometabolic risk and often display adverse changes in metabolic biomarkers compared with pre-menopausal women. It remains elusive whether the changes in cardiom...

    Authors: Qin Wang, Diana L. Santos Ferreira, Scott M. Nelson, Naveed Sattar, Mika Ala-Korpela and Debbie A. Lawlor
    Citation: BMC Medicine 2018 16:17
  38. Our aims were to evaluate critically the evidence from systematic reviews as well as narrative reviews of the effects of melatonin (MLT) on health and to identify the potential mechanisms of action involved.

    Authors: Pawel P. Posadzki, Ram Bajpai, Bhone Myint Kyaw, Nicola J. Roberts, Amnon Brzezinski, George I. Christopoulos, Ushashree Divakar, Shweta Bajpai, Michael Soljak, Gerard Dunleavy, Krister Jarbrink, Ei Ei Khaing Nang, Chee Kiong Soh and Josip Car
    Citation: BMC Medicine 2018 16:18
  39. The year 2016 has marked the highest number of displaced people worldwide on record. A large number of these refugees are women, yet little is known about their specific situation and the hurdles they have to ...

    Authors: Jenny Jesuthasan, Ekin Sönmez, Ingar Abels, Christine Kurmeyer, Jana Gutermann, Renate Kimbel, Antje Krüger, Guenter Niklewski, Kneginja Richter, Ulrich Stangier, Anja Wollny, Ulrike Zier, Sabine Oertelt-Prigione and Meryam Shouler-Ocak
    Citation: BMC Medicine 2018 16:15
  40. The built environment influences behaviour, like physical activity, diet and sleep, which affects the risk of type 2 diabetes mellitus (T2DM). This study systematically reviewed and meta-analysed evidence on t...

    Authors: N. R. den Braver, J. Lakerveld, F. Rutters, L. J. Schoonmade, J. Brug and J. W. J. Beulens
    Citation: BMC Medicine 2018 16:12

    The Correction to this article has been published in BMC Medicine 2021 19:63

  41. National guidance on preventing type 2 diabetes mellitus (T2DM) in the UK recommends low-intensity lifestyle interventions for individuals with intermediate categories of hyperglycaemia defined in terms of imp...

    Authors: Samantha Roberts, Dawn Craig, Amanda Adler, Klim McPherson and Trisha Greenhalgh
    Citation: BMC Medicine 2018 16:16
  42. Rotavirus causes severe gastroenteritis in infants and young children worldwide. The UK introduced the monovalent rotavirus vaccine (Rotarix®) in July 2013. Vaccination is free of charge to parents, with two d...

    Authors: Daniel Hungerford, Roberto Vivancos, Jonathan M. Read, Miren Iturriza-GÏŒmara, Neil French and Nigel A. Cunliffe
    Citation: BMC Medicine 2018 16:10
  43. Disability as a health outcome deserves more attention than it has so far received. With people living longer and the epidemiological transition from infectious to noncommunicable diseases as the major cause o...

    Authors: Alarcos Cieza, Carla Sabariego, Jerome Bickenbach and Somnath Chatterji
    Citation: BMC Medicine 2018 16:14
  44. Preterm prelabour rupture of the fetal membranes (PPROM) precedes 30% of preterm births and is a risk factor for early onset neonatal sepsis. As PPROM is strongly associated with ascending vaginal infection, p...

    Authors: Richard G. Brown, Julian R. Marchesi, Yun S. Lee, Ann Smith, Benjamin Lehne, Lindsay M. Kindinger, Vasso Terzidou, Elaine Holmes, Jeremy K. Nicholson, Phillip R. Bennett and David A. MacIntyre
    Citation: BMC Medicine 2018 16:9
  45. In 2016, the World Health Organization (WHO) recommended point-of-use fortification of complementary foods with iron-containing micronutrient powders to improve iron status and reduce anaemia in children at ri...

    Authors: Hans Verhoef, Emily Teshome and Andrew M. Prentice
    Citation: BMC Medicine 2018 16:7

    The original article was published in BMC Medicine 2017 15:99

    The original article was published in BMC Medicine 2017 15:89

  46. In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-...

    Authors: W. Robert Taylor, Htee Khu Naw, Kathryn Maitland, Thomas N. Williams, Melissa Kapulu, Umberto D’Alessandro, James A. Berkley, Philip Bejon, Joseph Okebe, Jane Achan, Alfred Ngwa Amambua, Muna Affara, Davis Nwakanma, Jean-Pierre van Geertruyden, Muhindo Mavoko, Pascal Lutumba…
    Citation: BMC Medicine 2018 16:11
  47. Antidepressant exposure during pregnancy has been associated with an increased risk of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in several observational studies. We pe...

    Authors: Daniel R. Morales, Jim Slattery, Stephen Evans and Xavier Kurz
    Citation: BMC Medicine 2018 16:6