From: Impact of a population-based HPV vaccination program on cervical abnormalities: a data linkage study
Outcome | Â | No. women-doses | No. abnormalities | Rate* | Hazard ratio |
---|---|---|---|---|---|
Histological abnormalities | |||||
Any high grade | Unvaccinated | 15,192 | 138 | 6.4 | 1.0 |
 | Vaccinated (unadjusted) |  |  |  | 0.76 (0.61 to 0.95) |
 | Vaccinated (adjusted) | 27,179 | 181 | 4.8 | 0.72 (0.58 to 0.91) |
 | 1 dose | 2,568 | 27 | 9.7 | 1.47 (0.97 to 2.23) |
 | 2 doses | 3,412 | 28 | 6.8 | 1.02 (0.68 to 1.53) |
 | 1 or 2 doses | 5,980 | 55 | 8.0 | 1.20 (0.88 to 1.65) |
 | Complete | 21,199 | 126 | 4.1 | 0.61 (0.48 to 0.78) |
CIN3/AIS | Unvaccinated | 15,192 | 61 | 2.8 | 1.0 |
 | Vaccinated (unadjusted) |  |  |  | 0.68 (0.48 to 0.95) |
 | Vaccinated (adjusted) | 27,179 | 70 | 1.9 | 0.64 (0.45 to 0.90) |
 | 1 dose | 2,568 | 12 | 4.3 | 1.40 (0.75 to 2.61) |
 | 2 doses | 3,412 | 11 | 2.7 | 0.87 (0.46 to 1.67) |
 | 1 or 2 doses | 5,980 | 23 | 3.3 | 1.09 (0.67 to 1.76) |
 | Complete | 21,199 | 47 | 1.5 | 0.53 (0.36 to 0.77) |
CIN2 | Unvaccinated | 15,192 | 87 | 4.0 | 1.0 |
 | Vaccinated (unadjusted) |  |  |  | 0.81 (0.61 to 1.06) |
 | Vaccinated (adjusted) | 27,179 | 122 | 3.2 | 0.78 (0.59 to 1.03) |
 | 1 dose | 2,568 | 16 | 5.7 | 1.29 (0.76 to 2.20) |
 | 2 doses | 3,412 | 18 | 4.4 | 0.99 (0.59 to 1.64) |
 | 1 or 2 doses | 5,980 | 34 | 4.9 | 1.11 (0.75 to 1.66) |
 | Complete | 21,199 | 88 | 2.9 | 0.70 (0.52 to 0.94) |
CIN1 | Unvaccinated | 15,192 | 163 | 7.5 | 1.0 |
 | Vaccinated (unadjusted) |  |  |  | 0.86 (0.70 to 1.05) |
 | Vaccinated (adjusted) | 27,179 | 244 | 6.5 | 0.83 (0.68 to 1.02) |
 | 1 dose | 2,568 | 20 | 7.2 | 0.89 (0.56 to 1.41) |
 | 2 doses | 3,412 | 30 | 7.3 | 0.90 (0.61 to 1.33) |
 | 1 or 2 doses | 5,980 | 50 | 7.2 | 0.90 (0.65 to 1.23) |
 | Complete | 21,199 | 194 | 6.3 | 0.82 (0.66 to 1.01) |
Cytological abnormalities | |||||
High-grade cytology | Unvaccinated | 15,192 | 325 | 15.3 | 1.0 |
 | Vaccinated (unadjusted) |  |  |  | 0.77 (0.67 to 0.89) |
 | Vaccinated (adjusted) | 27,179 | 442 | 11.9 | 0.75 (0.65 to 0.87) |
 | 1 dose | 2,568 | 44 | 16.0 | 0.85 (0.62 to 1.17) |
 | 2 doses | 3,412 | 67 | 16.5 | 0.95 (0.73 to 1.23) |
 | 1 or 2 doses | 5,980 | 111 | 16.3 | 0.91 (0.73 to 1.13) |
 | Complete | 21199 | 331 | 10.9 | 0.71 (0.61 to 0.83) |
Low-grade cytology | Unvaccinated | 15,192 | 2,306 | 125.8 | 1.0 |
 | Vaccinated (unadjusted) |  |  |  | 0.77 (0.73 to 0.82) |
 | Vaccinated (adjusted) | 27,179 | 3,184 | 95.3 | 0.76 (0.72 to 0.80) |
 | 1 dose | 2,568 | 250 | 101.9 | 0.67 (0.59 to 0.76) |
 | 2 doses | 3,412 | 328 | 89.2 | 0.64 (0.57 to 0.72) |
 | 1 or 2 doses | 5,980 | 578 | 94.3 | 0.66 (0.60 to 0.72) |
 | Complete | 21,199 | 2,606 | 95.5 | 0.79 (0.75 to 0.84) |