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  1. Previous findings on the associations of thiazide use with skin cancers were conflicting. This study aimed to examine the associations of individual thiazide use with skin cancer risk, differentiated by subtyp...

    Authors: Shih-Chieh Shao, Chien-Cheng Lai, Yi-Hung Chen, Edward Chia-Cheng Lai, Ming-Jui Hung and Ching-Chi Chi
    Citation: BMC Medicine 2022 20:228
  2. Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO def...

    Authors: Ekaterina Pazukhina, Margarita Andreeva, Ekaterina Spiridonova, Polina Bobkova, Anastasia Shikhaleva, Yasmin El-Taravi, Mikhail Rumyantsev, Aysylu Gamirova, Anastasiia Bairashevskaia, Polina Petrova, Dina Baimukhambetova, Maria Pikuza, Elina Abdeeva, Yulia Filippova, Salima Deunezhewa, Nikita Nekliudov…
    Citation: BMC Medicine 2022 20:244
  3. Recent publications reported a paradoxical finding that there was an inverse association between the number of standard modifiable risk factors (SMuRFs; smoking, hypertension, diabetes, and hyperlipidemia) and...

    Authors: Sidong Li, Xiaojin Gao, Jingang Yang, Haiyan Xu, Yang Wang, Yanyan Zhao, Lu Yin, Chao Wu, Yi Wang, Yang Zheng, Bao Li, Xuan Zhang, Yunqing Ye, Rui Fu, Qiuting Dong, Hui Sun…
    Citation: BMC Medicine 2022 20:217
  4. While the vaccines against COVID-19 are highly effective, COVID-19 vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants still circulating, describing the characteristics of...

    Authors: Amelia Green, Helen Curtis, William Hulme, Elizabeth Williamson, Helen McDonald, Krishnan Bhaskaran, Christopher Rentsch, Anna Schultze, Brian MacKenna, Viyaasan Mahalingasivam, Laurie Tomlinson, Alex Walker, Louis Fisher, Jon Massey, Colm Andrews, Lisa Hopcroft…
    Citation: BMC Medicine 2022 20:243
  5. The American Heart Association recommends Life’s Simple 7 as ideal cardiovascular health (ICVH) to reduce cardiovascular risk. Rate advancement period (RAP), a useful tool to quantify and communicate exposure ...

    Authors: Cesar I. Fernandez-Lazaro, Carmen Sayon-Orea, Estefania Toledo, Conchi Moreno-Iribas and María J. Guembe
    Citation: BMC Medicine 2022 20:232
  6. Accumulating evidence now indicates that the presence of faecal haemoglobin, in the absence of gastrointestinal bleeding, may be an indicator of systemic inflammation and is linked to the development of human ...

    Authors: Choong-Kyun Noh, Eunyoung Lee, Bumhee Park and Sung Soo Ahn
    Citation: BMC Medicine 2022 20:226
  7. Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the ...

    Authors: Tong Tong, Xing Qin, Yingying Jiang, Haiyan Guo, Xiaoning Wang, Yan Li, Fei Xie, Hao Lu, Peisong Zhai, Hailong Ma and Jianjun Zhang
    Citation: BMC Medicine 2022 20:231
  8. Placenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the identity and longitudinal patterns of such proteins are largely unknown...

    Authors: Maren-Helene Langeland Degnes, Ane Cecilie Westerberg, Manuela Zucknick, Theresa L. Powell, Thomas Jansson, Tore Henriksen, Marie Cecilie Paasche Roland and Trond Melbye Michelsen
    Citation: BMC Medicine 2022 20:227
  9. Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa. The pathogenesis and prognostic significance of BWF and AKI are not we...

    Authors: Andrea L. Conroy, Michael T. Hawkes, Aleksandra Leligdowicz, Ivan Mufumba, Michelle C. Starr, Kathleen Zhong, Sophie Namasopo, Chandy C. John, Robert O. Opoka and Kevin C. Kain
    Citation: BMC Medicine 2022 20:221
  10. In 2013, a few years after the launch of the National Institute of Mental Health’s Research Domain Criteria (RDoC) initiative, Cuthbert and Insel published a paper titled “Toward the future of psychiatric diag...

    Authors: Sarah E. Morris, Charles A. Sanislow, Jenni Pacheco, Uma Vaidyanathan, Joshua A. Gordon and Bruce N. Cuthbert
    Citation: BMC Medicine 2022 20:220
  11. Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are...

    Authors: Maoxiang Zhao, Lulu Song, Qianqian Zhao, Yating Chen, Bin Li, Zhonghui Xie, Zihao Fu, Nan Zhang, Xiaowei Cheng, Xiaoqian Li, Miao Wang, Shouling Wu, Hao Xue and Yang Li
    Citation: BMC Medicine 2022 20:215
  12. The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide. Contrary t...

    Authors: Tomabu Adjobimey, Julia Meyer, Vedrana Terkeš, Marijo Parcina and Achim Hoerauf
    Citation: BMC Medicine 2022 20:241
  13. Community pharmacies serve people with high levels of tobacco-related illness, but throughput in NHS Stop Smoking Services in pharmacies remains relatively low. We investigated the effectiveness of a complex i...

    Authors: Sandra Jumbe, Vichithranie W. Madurasinghe, Wai Yee James, Colin Houlihan, Samantha L. Jumbe, Tammy Yau, Florian Tomini, Sandra Eldridge, Borislava Mihaylova, Liz Steed, Ratna Sohanpal, Darush Attar, Stephanie J. C. Taylor, Chris Griffiths and Robert Walton
    Citation: BMC Medicine 2022 20:212
  14. The time of survival in patients with amyotrophic lateral sclerosis (ALS) varies greatly, and the genetic factors that contribute to the survival of ALS are not well studied. There is a lack of a comprehensive...

    Authors: Wei-Ming Su, Xiao-Jing Gu, Qing-Qing Duan, Zheng Jiang, Xia Gao, Hui-Fang Shang and Yong-Ping Chen
    Citation: BMC Medicine 2022 20:209
  15. Previous genome-wide association studies (GWAS) have identified numerous risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the disease. We employed an integrative analyt...

    Authors: Chengcheng Zhang, Fengqin Qin, Xiaojing Li, Xiangdong Du and Tao Li
    Citation: BMC Medicine 2022 20:211
  16. The current genome-wide association study (GWAS) of Lewy body dementia (LBD) suffers from low power due to a limited sample size. In addition, the genetic determinants underlying LBD and the shared genetic eti...

    Authors: Ping Guo, Weiming Gong, Yuanming Li, Lu Liu, Ran Yan, Yanjun Wang, Yanan Zhang and Zhongshang Yuan
    Citation: BMC Medicine 2022 20:214
  17. Preliminary evidence suggests that providing longer duration prescriptions at discharge may improve long-term adherence to secondary preventative cardiac medications among post-myocardial infarction (MI) patie...

    Authors: J. D. Schwalm, Noah M. Ivers, Zachary Bouck, Monica Taljaard, Madhu K. Natarajan, Francis Nguyen, Waseem Hijazi, Kednapa Thavorn, Lisa Dolovich, Tara McCready, Erin O’Brien and Jeremy M. Grimshaw
    Citation: BMC Medicine 2022 20:213
  18. We aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association.

    Authors: Jacob Blankenberger, Marco Kaufmann, Emiliano Albanese, Rebecca Amati, Daniela Anker, Anne-Linda Camerini, Patricia Chocano-Bedoya, Stéphane Cullati, Alexia Cusini, Jan Fehr, Erika Harju, Philipp Kohler, Susi Kriemler, Gisela Michel, Nicolas Rodondi, Pierre-Yves Rodondi…
    Citation: BMC Medicine 2022 20:233
  19. Recent guidelines recommended a systolic blood pressure (SBP) target of < 130 mmHg for patients with or without diabetes but without providing a lower bound. Our study aimed to explore whether additional clini...

    Authors: Chao Li, Kangyu Chen, Guoshuai Shi, Rui Shi, Zhenqiang Wu, Xiaodan Yuan, Vicky Watson, Zhixin Jiang, Hui Mai, Tian Yang, Duolao Wang and Tao Chen
    Citation: BMC Medicine 2022 20:208
  20. Osteoarthritis (OA) is a worldwide public health concern, mainly afflicting older adults. Although the etiology of OA remains unclear, environmental factors are increasingly considered as non-negligible risk f...

    Authors: Li Chen, Ying Zhao, Fangqu Liu, Huimin Chen, Tianqi Tan, Ping Yao and Yuhan Tang
    Citation: BMC Medicine 2022 20:207
  21. Despite large outbreaks in humans seeming improbable for a number of zoonotic pathogens, several pose a concern due to their epidemiological characteristics and evolutionary potential. To enable effective resp...

    Authors: Anita Lerch, Quirine A. ten Bosch, Maïna L’Azou Jackson, Alison A. Bettis, Mauro Bernuzzi, Georgina A. V. Murphy, Quan M. Tran, John H. Huber, Amir S. Siraj, Gebbiena M. Bron, Margaret Elliott, Carson S. Hartlage, Sojung Koh, Kathyrn Strimbu, Magdalene Walters, T. Alex Perkins…
    Citation: BMC Medicine 2022 20:202
  22. The interplay among the plant-based dietary pattern, gut microbiota, and cardiometabolic health is still unclear, and evidence from large prospective cohorts is rare. We aimed to examine the association of lon...

    Authors: Zelei Miao, Wenwen Du, Congmei Xiao, Chang Su, Wanglong Gou, Luqi Shen, Jiguo Zhang, Yuanqing Fu, Zengliang Jiang, Zhihong Wang, Xiaofang Jia, Ju-Sheng Zheng and Huijun Wang
    Citation: BMC Medicine 2022 20:204
  23. The epidemiological international landscape of traumatic spinal cord injury (SCI) has evolved over the last decades along with given inherent differences in acute care and rehabilitation across countries and j...

    Authors: Lucie Bourguignon, Bobo Tong, Fred Geisler, Martin Schubert, Frank Röhrich, Marion Saur, Norbert Weidner, Rüdiger Rupp, Yorck-Bernhard B. Kalke, Rainer Abel, Doris Maier, Lukas Grassner, Harvinder S. Chhabra, Thomas Liebscher, Jacquelyn J. Cragg, John Kramer…
    Citation: BMC Medicine 2022 20:225
  24. Neurofilament light chain (NfL) is released into the blood during neuronal damage. NfL is linked to mortality in neurological disorders, remaining unexplored in population studies. We investigated whether init...

    Authors: May A. Beydoun, Nicole Noren Hooten, Jordan Weiss, Hind A. Beydoun, Sharmin Hossain, Michele K. Evans and Alan B. Zonderman
    Citation: BMC Medicine 2022 20:218
  25. Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence linking PUFA to cardiovascular diseases (CVDs). We inv...

    Authors: Maria Carolina Borges, Philip C. Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith, Aroon D. Hingorani and Deborah A. Lawlor
    Citation: BMC Medicine 2022 20:210
  26. Epidemiological studies have demonstrated a favorable association of whole grain intake with coronary heart disease (CHD) risk, although whether such an inverse association holds true for individual whole grai...

    Authors: Yang Hu, Walter C. Willett, Jo Ann E. Manson, Bernard Rosner, Frank B. Hu and Qi Sun
    Citation: BMC Medicine 2022 20:192
  27. Chile was severely affected by COVID19 outbreaks but was also one of the first countries to start a nationwide program to vaccinate against the disease. Furthermore, Chile became one of the fastest countries t...

    Authors: Leonardo Vargas, Nicolás Valdivieso, Fabián Tempio, Valeska Simon, Daniela Sauma, Lucía Valenzuela, Caroll Beltrán, Loriana Castillo-Delgado, Ximena Contreras-Benavides, Mónica L. Acevedo, Johanna Acevedo, Rafael I. Gonzalez, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Mario Rosemblatt, Mercedes Lopez…
    Citation: BMC Medicine 2022 20:216
  28. Because most cervical cancers are caused by high-risk human papillomaviruses (hrHPVs), cervical cancer prevention programs increasingly employ hrHPV testing as a primary test. The high sensitivity of HPV tests...

    Authors: Karolina M. Andralojc, Duaa Elmelik, Menno Rasing, Bernard Pater, Albert G. Siebers, Ruud Bekkers, Martijn A. Huynen, Johan Bulten, Diede Loopik, Willem J. G. Melchers and William P. J. Leenders
    Citation: BMC Medicine 2022 20:206
  29. In Papua (Indonesia), infants with P. falciparum and/or P. vivax malaria are at risk of severe anaemia and death. We hypothesized that in an area of high malaria transmission, intermittent screening and treatment...

    Authors: Jeanne Rini Poespoprodjo, Hafiidhaturrahmah, Novita Sariyanti, Ratni Indrawanti, Alistair R. D. McLean, Julie A. Simpson, Enny Kenangalem, Faustina Helena Burdam, Rintis Noviyanti, Leily Trianty, Chairunisa Fadhilah, Yati Soenarto and Ric N. Price
    Citation: BMC Medicine 2022 20:190
  30. In current care, patients’ personal and self-reported family histories are primarily used to determine whether genetic testing for hereditary endocrine tumor syndromes (ETS) is indicated. Population genomic sc...

    Authors: Juliann M. Savatt, Nicole M. Ortiz, Gretchen M. Thone, Whitney S. McDonald, Melissa A. Kelly, Alexander S. F. Berry, Madiha M. Alvi, Miranda L. G. Hallquist, Jennifer Malinowski, Nicholas C. Purdy, Marc S. Williams, Amy C. Sturm and Adam H. Buchanan
    Citation: BMC Medicine 2022 20:205
  31. Body mass index (BMI) has been found to be associated with a decreased risk of non-small cell lung cancer (NSCLC); however, the effect of BMI trajectories and potential interactions with genetic variants on NS...

    Authors: Dongfang You, Danhua Wang, Yaqian Wu, Xin Chen, Fang Shao, Yongyue Wei, Ruyang Zhang, Theis Lange, Hongxia Ma, Hongyang Xu, Zhibin Hu, David C. Christiani, Hongbing Shen, Feng Chen and Yang Zhao
    Citation: BMC Medicine 2022 20:203
  32. Cardiometabolic multimorbidity (CM) is an increasing public health and clinical concern. However, predictors for the development and prognosis of CM are poorly understood. The aims of this study were to invest...

    Authors: Yanqiang Lu, Guochen Li, Pietro Ferrari, Heinz Freisling, Yanan Qiao, Luying Wu, Liping Shao and Chaofu Ke
    Citation: BMC Medicine 2022 20:191
  33. Muscle weakness, which increases in prevalence with age, is a major public health concern. Grip strength is commonly used to identify weakness and an improved understanding of its determinants is required. We ...

    Authors: Snehal M. Pinto Pereira, Victoria Garfield, Aliki-Eleni Farmaki, David J. Tomlinson, Thomas Norris, Ghazaleh Fatemifar, Spiros Denaxas, Chris Finan and Rachel Cooper
    Citation: BMC Medicine 2022 20:201
  34. Long-term morbidity after pediatric intensive care unit (PICU) admission is a growing concern. Both critical illness and accompanying PICU treatments may impact neurocognitive development as assessed by its go...

    Authors: Eleonore S. V. de Sonnaville, Marsh Kӧnigs, Ouke van Leijden, Hennie Knoester, Job B. M. van Woensel and Jaap Oosterlaan
    Citation: BMC Medicine 2022 20:198
  35. There is no consensus on the most efficient catheter ablation (CA) strategy for patients with atrial fibrillation (AF). The objective of this study was to compare the efficacy and safety of different CA strate...

    Authors: Emmanouil Charitakis, Silvia Metelli, Lars O. Karlsson, Antonios P. Antoniadis, Konstantinos D. Rizas, Ioan Liuba, Henrik Almroth, Anders Hassel Jönsson, Jonas Schwieler, Dimitrios Tsartsalis, Skevos Sideris, Elena Dragioti, Nikolaos Fragakis and Anna Chaimani
    Citation: BMC Medicine 2022 20:193
  36. Despite the reported efficacy of osimertinib, central nervous system (CNS) progression is still frequent in EGFR-mutated NSCLC. This study aimed to reveal site-specific resistant mechanisms to osimertinib and inv...

    Authors: Mei-Mei Zheng, Yang-Si Li, Hai-Yan Tu, Hao Sun, Kai Yin, Ben-Yuan Jiang, Jin-Ji Yang, Xu-Chao Zhang, Qing Zhou, Chong-Rui Xu, Zhen Wang, Hua-Jun Chen, De-Xiang Zhou and Yi-Long Wu
    Citation: BMC Medicine 2022 20:197
  37. Little is known regarding life-course trajectories of important diseases. We aimed to identify diseases that were strongly associated with mortality and test temporal trajectories of these diseases before mort...

    Authors: Xianwen Shang, Xueli Zhang, Yu Huang, Zhuoting Zhu, Xiayin Zhang, Shunming Liu, Jiahao Liu, Shulin Tang, Wei Wang, Honghua Yu, Zongyuan Ge and Mingguang He
    Citation: BMC Medicine 2022 20:185
  38. There is limited knowledge regarding the process of deprescribing psychotropic drugs to people with dementia (PwD) conducted by general practitioners (GP). We investigated the impact of a multicomponent interv...

    Authors: Marie H. Gedde, Bettina S. Husebo, Janne Mannseth, Mala Naik, Geir Selbaek, Maarja Vislapuu and Line Iden Berge
    Citation: BMC Medicine 2022 20:186
  39. Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage....

    Authors: Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni, Leslie Myatt, Wang-sheng Wang and Kang Sun
    Citation: BMC Medicine 2022 20:189
  40. Long distance heavy goods vehicle (HGV) drivers exhibit higher than nationally representative rates of obesity, and obesity-related co-morbidities, and are underserved in terms of health promotion initiatives....

    Authors: Stacy A. Clemes, Veronica Varela-Mato, Danielle H. Bodicoat, Cassandra L. Brookes, Yu-Ling Chen, Charlotte L. Edwardson, Laura J. Gray, Amber J. Guest, Vicki Johnson, Fehmidah Munir, Nicola J. Paine, Gerry Richardson, Katharina Ruettger, Mohsen Sayyah, Aron Sherry, Ana Suazo Di Paola…
    Citation: BMC Medicine 2022 20:195
  41. Stroke is one of the major challenges for the global healthcare system, which makes it necessary to explore the relationship between various modifiable factors and stroke risk. Recently, numerous meta-analyses...

    Authors: Na Guo, Ying Zhu, Dandan Tian, Yating Zhao, Chenguang Zhang, Changqing Mu, Chen Han, Ruixia Zhu and Xu Liu
    Citation: BMC Medicine 2022 20:194
  42. Whether the associations of time spent in screen-based sedentary activities with CHD vary by genetic susceptibility is currently unknown. The objective of this study was to examine the interplay of genetic sus...

    Authors: Youngwon Kim, Shiu Lun Au Yeung, Stephen J. Sharp, Mengyao Wang, Haeyoon Jang, Shan Luo, Soren Brage and Katrien Wijndaele
    Citation: BMC Medicine 2022 20:188
  43. It was urgent and necessary to synthesize the evidence for vaccine effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a systematic review and meta-analysis to provide a comprehensive...

    Authors: Baoqi Zeng, Le Gao, Qingxin Zhou, Kai Yu and Feng Sun
    Citation: BMC Medicine 2022 20:200
  44. As we are confronted with more transmissible/severe variants with immune escape and the waning of vaccine efficacy, it is particularly relevant to understand how the social contacts of individuals at greater r...

    Authors: Aurélie Godbout, Mélanie Drolet, Myrto Mondor, Marc Simard, Chantal Sauvageau, Gaston De Serres and Marc Brisson
    Citation: BMC Medicine 2022 20:199
  45. Transparency and reproducibility are expected to be normative practices in clinical trials used for decision-making on marketing authorisations for new medicines. This registered report introduces a cross-sect...

    Authors: Maximilian Siebert, Jeanne Gaba, Alain Renault, Bruno Laviolle, Clara Locher, David Moher and Florian Naudet
    Citation: BMC Medicine 2022 20:177
  46. The temporal relationship between adiposity and gut microbiota was unexplored. Whether some gut microbes lie in the pathways from adiposity to insulin resistance is less clear. Our study aims to reveal the tem...

    Authors: Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng and Yu-ming Chen
    Citation: BMC Medicine 2022 20:171
  47. Recent years have seen important improvements in available preventive treatment regimens for tuberculosis (TB), and research is ongoing to develop these further. To assist with the formulation of target produc...

    Authors: Juan F. Vesga, Christian Lienhardt, Placide Nsengiyumva, Jonathon R. Campbell, Olivia Oxlade, Saskia den Boon, Dennis Falzon, Kevin Schwartzman, Gavin Churchyard and Nimalan Arinaminpathy
    Citation: BMC Medicine 2022 20:182
  48. The ubiquity of Internet connectivity, and widespread unmet needs, requires investigations of digital interventions for people seeking help with their drinking. The objective of this study was to test the effe...

    Authors: Marcus Bendtsen, Katarina Åsberg and Jim McCambridge
    Citation: BMC Medicine 2022 20:176
  49. This study examines mental, neurological, and substance use (MNS) service usage within refugee camp primary health care facilities in low- and middle-income countries (LMICs) by analyzing surveillance data fro...

    Authors: Shoshanna L. Fine, Jeremy C. Kane, Paul B. Spiegel, Wietse A. Tol and Peter Ventevogel
    Citation: BMC Medicine 2022 20:183