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  1. Research article

    A 25-gene classifier predicts overall survival in resectable pancreatic cancer

    Pancreatic carcinoma is one of the most lethal human cancers. In patients with resectable tumors, surgery followed by adjuvant chemotherapy is the only curative treatment. However, the 5-year survival is 20%. ...

    David J. Birnbaum, Pascal Finetti, Alexia Lopresti, Marine Gilabert, Flora Poizat, Jean-Luc Raoul, Jean-Robert Delpero, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier and François Bertucci

    BMC Medicine 2017 15:170

    Published on: 20 September 2017

  2. Research article

    Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

    A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to ...

    Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E. Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva…

    BMC Medicine 2017 15:172

    Published on: 18 September 2017

  3. Research article

    Borrelia infection and risk of celiac disease

    Environmental factors, including infectious agents, are speculated to play a role in the rising prevalence and the geographic distribution of celiac disease, an autoimmune disorder. In the USA and Sweden where...

    Armin Alaedini, Benjamin Lebwohl, Gary P. Wormser, Peter H. Green and Jonas F. Ludvigsson

    BMC Medicine 2017 15:169

    Published on: 15 September 2017

  4. Research article

    Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial

    A highly efficacious vaccine is needed for malaria control and eradication. Immunization with Plasmodium falciparum NF54 parasites under chemoprophylaxis (chemoprophylaxis and sporozoite (CPS)-immunization) induc...

    Jona Walk, Isaie J. Reuling, Marije C. Behet, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Thorsten Janssen, Karina Teelen, Johannes H. W. de Wilt, Quirijn de Mast, André J. van der Ven, Ernest Diez Benavente, Susana Campino, Taane G. Clark…

    BMC Medicine 2017 15:168

    Published on: 13 September 2017

  5. Correspondence

    Core competencies for scientific editors of biomedical journals: consensus statement

    Scientific editors are responsible for deciding which articles to publish in their journals. However, we have not found documentation of their required knowledge, skills, and characteristics, or the existence ...

    David Moher, James Galipeau, Sabina Alam, Virginia Barbour, Kidist Bartolomeos, Patricia Baskin, Sally Bell-Syer, Kelly D. Cobey, Leighton Chan, Jocalyn Clark, Jonathan Deeks, Annette Flanagin, Paul Garner, Anne-Marie Glenny, Trish Groves, Kurinchi Gurusamy…

    BMC Medicine 2017 15:167

    Published on: 11 September 2017

  6. Research article

    Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in England

    As part of the national seasonal influenza vaccination programme in England and Wales, children receive a quadrivalent vaccine offering protection against two influenza A strains and two influenza B strains. H...

    Dominic Thorrington, Edwin van Leeuwen, Mary Ramsay, Richard Pebody and Marc Baguelin

    BMC Medicine 2017 15:166

    Published on: 8 September 2017

  7. Research article

    A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

    Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. Human papillomavirus (HPV)-positive status is recognized as a marker of inc...

    Jean-Philippe Foy, Louis Bazire, Sandra Ortiz-Cuaran, Sophie Deneuve, Janice Kielbassa, Emilie Thomas, Alain Viari, Alain Puisieux, Patrick Goudot, Chloé Bertolus, Nicolas Foray, Youlia Kirova, Pierre Verrelle and Pierre Saintigny

    BMC Medicine 2017 15:165

    Published on: 1 September 2017

  8. Research article

    Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study

    While being small-for-gestational-age due to placental insufficiency is a major risk factor for stillbirth, 50% of stillbirths occur in appropriate-for-gestational-age (AGA, > 10th centile) fetuses. AGA fetuse...

    Teresa M. MacDonald, Lisa Hui, Stephen Tong, Alice J. Robinson, Kirsten M. Dane, Anna L. Middleton and Susan P. Walker

    BMC Medicine 2017 15:164

    Published on: 31 August 2017

  9. Research article

    A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial

    There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-inte...

    Mahen Wijesuriya, Nikolaos Fountoulakis, Nicola Guess, Sarath Banneheka, Laksha Vasantharajah, Martin Gulliford, Giancarlo Viberti, Luigi Gnudi and Janaka Karalliedde

    BMC Medicine 2017 15:146

    Published on: 30 August 2017

  10. Research article

    Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting

    In lung cancer screening, a nodule management protocol describes nodule assessment and thresholds for nodule size and growth rate to identify patients who require immediate diagnostic evaluation or additional ...

    Marina Treskova, Ines Aumann, Heiko Golpon, Jens Vogel-Claussen, Tobias Welte and Alexander Kuhlmann

    BMC Medicine 2017 15:162

    Published on: 25 August 2017

  11. Research article

    The contribution of risk factors to socioeconomic inequalities in multimorbidity across the lifecourse: a longitudinal analysis of the Twenty-07 cohort

    Multimorbidity is a major challenge to health systems globally and disproportionately affects socioeconomically disadvantaged populations. We examined socioeconomic inequalities in developing multimorbidity ac...

    Srinivasa Vittal Katikireddi, Kathryn Skivington, Alastair H. Leyland, Kate Hunt and Stewart W Mercer

    BMC Medicine 2017 15:152

    Published on: 24 August 2017

  12. Research article

    Association of bariatric surgery with risk of acute care use for hypertension-related disease in obese adults: population-based self-controlled case series study

    Hypertension carries a large societal burden. Obesity is known as a risk factor for hypertension. However, little is known as to whether weight loss interventions reduce the risk of hypertension-related advers...

    Yuichi J. Shimada, Yusuke Tsugawa, Hiroyasu Iso, David F. M. Brown and Kohei Hasegawa

    BMC Medicine 2017 15:161

    Published on: 23 August 2017

  13. Research article

    The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis

    Conflicting results regarding the impact of repeated vaccination on influenza vaccine effectiveness (VE) may cause confusion regarding the benefits of receiving the current season’s vaccine.

    Lauren C. Ramsay, Sarah A. Buchan, Robert G. Stirling, Benjamin J. Cowling, Shuo Feng, Jeffrey C. Kwong and Bryna F. Warshawsky

    BMC Medicine 2017 15:159

    Published on: 21 August 2017

  14. Minireview

    What makes gouty inflammation so variable?

    Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to...

    Robert Terkeltaub

    BMC Medicine 2017 15:158

    Published on: 18 August 2017

  15. Commentary

    Circulating tumor DNA for personalized lung cancer monitoring

    Advances in deep sequencing technology have led to developments in personalized medicine. Here, we describe the implications of a recent investigation that sequenced ctDNA from the plasma of non-small cell lun...

    Clare Fiala and Eleftherios P. Diamandis

    BMC Medicine 2017 15:157

    Published on: 17 August 2017

  16. Research article

    Intervention Now to Eliminate Repeat Unintended Pregnancy in Teenagers (INTERUPT): a systematic review of intervention effectiveness and cost-effectiveness, and qualitative and realist synthesis of implementation factors and user engagement

    Unintended repeat conceptions can result in emotional, psychological and educational harm to young women, often with enduring implications for their life chances. This study aimed to identify which young women...

    Rabeea’h W. Aslam, Maggie Hendry, Andrew Booth, Ben Carter, Joanna M. Charles, Noel Craine, Rhiannon Tudor Edwards, Jane Noyes, Lupetu Ives Ntambwe, Diana Pasterfield, Jo Rycroft-Malone, Nefyn Williams and Rhiannon Whitaker

    BMC Medicine 2017 15:155

    Published on: 15 August 2017

  17. Research article

    Gestational hypertensive disorders and retinal microvasculature: the Generation R Study

    Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestationa...

    Laura Benschop, Sarah Schalekamp–Timmermans, Jeanine E. Roeters van Lennep, Vincent W. V. Jaddoe, Tien Yin Wong, Carol Y. Cheung, Eric A. P. Steegers and Kamran M. Ikram

    BMC Medicine 2017 15:153

    Published on: 14 August 2017

  18. Research article

    Risk and predictors of psoriasis in patients with breast cancer: a Swedish population-based cohort study

    The risk of psoriasis in patients with breast cancer is largely unknown, as available evidence is limited to case findings. We systematically examined the incidence and risk factors of psoriasis in patients wi...

    Haomin Yang, Judith S. Brand, Jingmei Li, Jonas F. Ludvigsson, Emilio Ugalde-Morales, Flaminia Chiesa, Per Hall and Kamila Czene

    BMC Medicine 2017 15:154

    Published on: 11 August 2017

  19. Research article

    Characterizing measles transmission in India: a dynamic modeling study using verbal autopsy data

    Decreasing trends in measles mortality have been reported in recent years. However, such estimates of measles mortality have depended heavily on assumed regional measles case fatality risks (CFRs) and made lit...

    Stéphane Verguet, Edward O. Jones, Mira Johri, Shaun K. Morris, Wilson Suraweera, Cindy L. Gauvreau, Prabhat Jha and Mark Jit

    BMC Medicine 2017 15:151

    Published on: 10 August 2017

  20. Research article

    Consistency and sources of divergence in recommendations on screening with questionnaires for presently experienced health problems or symptoms: a comparison of recommendations from the Canadian Task Force on Preventive Health Care, UK National Screening Committee, and US Preventive Services Task Force

    Recently, health screening recommendations have gone beyond screening for early-stage, asymptomatic disease to include “screening” for presently experienced health problems and symptoms using self-report quest...

    Brett D. Thombs, Nazanin Saadat, Kira E. Riehm, Justin Michael Karter, Akansha Vaswani, Bonnie K. Andrews, Peter Simons and Lisa Cosgrove

    BMC Medicine 2017 15:150

    Published on: 9 August 2017

  21. Research article

    Pregnancy, pregnancy loss, and the risk of cardiovascular disease in Chinese women: findings from the China Kadoorie Biobank

    Pregnancy and pregnancy loss may be linked to cardiovascular disease (CVD). However, the evidence is still inconsistent, especially in East Asians, whose reproductive patterns differ importantly from those in ...

    Sanne A. E. Peters, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Xiaocao Tian, Liang Chang, Shuo Zhang, Jiaqiu Liu, Tao Wang, Junshi Chen, Liming Li, Mark Woodward and Zhengming Chen

    BMC Medicine 2017 15:148

    Published on: 8 August 2017

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