Citation: BMC Medicine 2021 19:25
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Citation: BMC Medicine 2021 19:16
Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study
The National Early Warning Score (NEWS2) is currently recommended in the UK for the risk stratification of COVID-19 patients, but little is known about its ability to detect severe cases. We aimed to evaluate ...
Citation: BMC Medicine 2021 19:23
In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study
In utero exposure to Zika virus (ZIKV) is known to be associated with birth defects. The impact of in utero ZIKV exposure on neurodevelopmental outcomes in early childhood remains unclear. The objective of thi...
Citation: BMC Medicine 2021 19:12
Much progress has been made in mapping genetic abnormalities linked to amyotrophic lateral sclerosis (ALS), but the majority of cases still present with no known underlying cause. Furthermore, even in families...
Citation: BMC Medicine 2021 19:13
rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues
It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the role of TMEM106B in Alzheimer’s disease (AD)....
Citation: BMC Medicine 2021 19:11
Model-based comorbidity clusters in patients with heart failure: association with clinical outcomes and healthcare utilization
Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between co...
Citation: BMC Medicine 2021 19:9
Citation: BMC Medicine 2021 19:17
Association of sickle cell disease with anthropometric indices among under-five children: evidence from 2018 Nigeria Demographic and Health Survey
Malnutrition continues to affect under-five children in Africa to an overwhelming proportion. The situation is further compounded by the burden of sickle cell disease (SCD). However, association of SCD with st...
Citation: BMC Medicine 2021 19:5
Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain
A high body mass index (BMI) has been associated with increased risk of several cancers; however, whether BMI is related to a larger number of cancers than currently recognized is unclear. Moreover, whether wa...
Citation: BMC Medicine 2021 19:10
Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews
The etiologies of chronic neurological diseases, which heavily contribute to global disease burden, remain far from elucidated. Despite available umbrella reviews on single contributing factors or diseases, no...
Citation: BMC Medicine 2021 19:6
Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19
Cross-reactivity to SARS-CoV-2 from exposure to endemic human coronaviruses (eHCoV) is gaining increasing attention as a possible driver of both protection against infection and COVID-19 severity. Here we expl...
Citation: BMC Medicine 2021 19:19
Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study
Alcohol consumption is a leading contributor to death and disability worldwide, but previous research has not examined the effects of different patterns of alcohol consumption. The study objective was to under...
Citation: BMC Medicine 2021 19:8
Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study
Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relatio...
Citation: BMC Medicine 2021 19:7
Development of a predictive model for integrated medical and long-term care resource consumption based on health behaviour: application of healthcare big data of patients with circulatory diseases
Medical costs and the burden associated with cardiovascular disease are on the rise. Therefore, to improve the overall economy and quality assessment of the healthcare system, we developed a predictive model o...
Citation: BMC Medicine 2021 19:15
Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover ...
Citation: BMC Medicine 2021 19:4
Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial
The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditio...
Citation: BMC Medicine 2021 19:3
Through a combination of strong routine immunization (RI), strategic supplemental immunization activities (SIA) and robust surveillance, numerous countries have been able to approach or achieve measles elimina...
Citation: BMC Medicine 2021 19:2
Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle ...
Citation: BMC Medicine 2021 19:1
Clinical outcomes in patients with atrial fibrillation and frailty: insights from the ENGAGE AF-TIMI 48 trial
Atrial fibrillation (AF) is common in older people with frailty and is associated with an increased risk of stroke and systemic embolism. Whilst oral anticoagulation is associated with a reduction in this risk...
Citation: BMC Medicine 2020 18:401
Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight
Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-gestational-age (SGA; weight < 10th centile) is a commonly used proxy for FGR, detection of ...
Citation: BMC Medicine 2020 18:395
Understanding personalized dynamics to inform precision medicine: a dynamic time warp analysis of 255 depressed inpatients
Major depressive disorder (MDD) shows large heterogeneity of symptoms between patients, but within patients, particular symptom clusters may show similar trajectories. While symptom clusters and networks have ...
Citation: BMC Medicine 2020 18:400
Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study
In pregnancy lipid levels increase with gestation resembling an atherogenic lipid profile. Currently it is unclear whether gestational lipid levels are associated with an adverse cardiovascular risk profile la...
Citation: BMC Medicine 2020 18:394
Development and validation of an artificial intelligence system for grading colposcopic impressions and guiding biopsies
Colposcopy diagnosis and directed biopsy are the key components in cervical cancer screening programs. However, their performance is limited by the requirement for experienced colposcopists. This study aimed t...
Citation: BMC Medicine 2020 18:406
Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis
Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detec...
Citation: BMC Medicine 2020 18:393
Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial
The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of person...
Citation: BMC Medicine 2020 18:407
Oral rehydration therapies in Senegal, Mali, and Sierra Leone: a spatial analysis of changes over time and implications for policy
Oral rehydration solution (ORS) is a simple intervention that can prevent childhood deaths from severe diarrhea and dehydration. In a previous study, we mapped the use of ORS treatment subnationally and found ...
Citation: BMC Medicine 2020 18:405
Increased care at discharge from COVID-19: The association between pre-admission frailty and increased care needs after hospital discharge; a multicentre European observational cohort study
The COVID-19 pandemic has placed significant pressure on health and social care. Survivors of COVID-19 may be left with substantial functional deficits requiring ongoing care. We aimed to determine whether pre...
Citation: BMC Medicine 2020 18:408
Allocation of intensive care resources during an infectious disease outbreak: a rapid review to inform practice
The COVID-19 pandemic has placed sustained demand on health systems globally, and the capacity to provide critical care has been overwhelmed in some jurisdictions. It is unknown which triage criteria for alloc...
Citation: BMC Medicine 2020 18:404
Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are a...
Citation: BMC Medicine 2020 18:403
Changes in evidence for studies assessing interventions for COVID-19 reported in preprints: meta-research study
The increasing use of preprints to disseminate evidence on the effect of interventions for the coronavirus disease 2019 (COVID-19) can lead to multiple evidence sources for a single study, which may differ in ...
Citation: BMC Medicine 2020 18:402
Zika virus (ZIKV) emerged as a global epidemic in 2015–2016 from Latin America with its true geographical extent remaining unclear due to widely presumed underreporting. The identification of locations with po...
Citation: BMC Medicine 2020 18:399
Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adi...
Citation: BMC Medicine 2020 18:396
Dementia is caused by a variety of neurodegenerative diseases and is associated with a decline in memory and other cognitive abilities, while inflicting an enormous socioeconomic burden. The complexity of deme...
Citation: BMC Medicine 2020 18:398
Mobile health innovations are well adapted for ambulatory coronavirus disease 2019 (COVID-19) patients who risk clinical deterioration at home during the second week of illness.
Citation: BMC Medicine 2020 18:391
Early detection of cholera epidemics to support control in fragile states: estimation of delays and potential epidemic sizes
Cholera epidemics continue to challenge disease control, particularly in fragile and conflict-affected states. Rapid detection and response to small cholera clusters is key for efficient control before an epid...
Citation: BMC Medicine 2020 18:397
The proportion of infections among young children that are antimicrobial-resistant is increasing across the globe. Newborns may be colonized with enteric antimicrobial-resistant pathogens early in life, which ...
Citation: BMC Medicine 2020 18:392
Development and validation of the VitaL CLASS score to predict mortality in stage IV solid cancer patients with septic shock in the emergency department: a multi-center, prospective cohort study
Clinical decision-making of invasive high-intensity care for critically ill stage IV cancer patients in the emergency department (ED) is challenging. A reliable and clinically available prognostic score for ad...
Citation: BMC Medicine 2020 18:390
The impact of HIV infection on tuberculosis transmission in a country with low tuberculosis incidence: a national retrospective study using molecular epidemiology
HIV is known to increase the likelihood of reactivation of latent tuberculosis to active TB disease; however, its impact on tuberculosis infectiousness and consequent transmission is unclear, particularly in l...
Citation: BMC Medicine 2020 18:385
Updated adolescent diagnostic criteria for polycystic ovary syndrome: impact on prevalence and longitudinal body mass index trajectories from birth to adulthood
Polycystic ovary syndrome (PCOS) is challenging to diagnose. While the 2003 Rotterdam criteria are widely used for adults, the 2018 international PCOS guideline recommended updated Rotterdam criteria with both...
Citation: BMC Medicine 2020 18:389
Effectiveness of training interventions to improve quality of medical certification of cause of death: systematic review and meta-analysis
Valid cause of death data are essential for health policy formation. The quality of medical certification of cause of death (MCCOD) by physicians directly affects the utility of cause of death data for public ...
Citation: BMC Medicine 2020 18:384
The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Pancreatitis is a critical public health problem, and the burden of pancreatitis is increasing. We report the rates and trends of the prevalence, incidence, and years lived with disability (YLDs) for pancreati...
Citation: BMC Medicine 2020 18:388
Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study
Methylmalonic acid (MMA) is best known for its use as a functional marker of vitamin B12 deficiency. However, MMA concentrations not only depend on adequate vitamin B12 status, but also relate to renal functio...
Citation: BMC Medicine 2020 18:380
Risk of mortality associated with concomitant antidepressant and benzodiazepine therapy among patients with depression: a population-based cohort study
With antidepressants (ADs) having minimal therapeutic effects during the initial weeks of treatment, benzodiazepines (BZDs) are concomitantly used to alleviate depressive symptoms of insomnia or anxiety. Howev...
Citation: BMC Medicine 2020 18:387
Citation: BMC Medicine 2020 18:379
Long-term care facilities (LTCFs) are vulnerable to outbreaks of coronavirus disease 2019 (COVID-19). Timely epidemiological surveillance is essential for outbreak response, but is complicated by a high propor...
Citation: BMC Medicine 2020 18:386
The efficacy and safety of methylprednisolone in hepatitis B virus-related acute-on-chronic liver failure: a prospective multi-center clinical trial
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe condition with high mortality due to lack of efficient therapy. Until now, the use of methylprednisolone (MP) in HBV-ACLF is stil...
Citation: BMC Medicine 2020 18:383
Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study
Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of mul...
Citation: BMC Medicine 2020 18:382
Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer
Clinical studies indicate chemotherapy agents used in childhood cancer treatment regimens may impact future fertility. However, effects of individual agents on prepubertal human testis, necessary to identify l...
Citation: BMC Medicine 2020 18:374
Choice across 10 pharmacologic combination strategies for type 2 diabetes: a cost-effectiveness analysis
Clinical guidelines recommend a stepped-escalation treatment strategy for type 2 diabetes (T2DM). Across multiple treatment strategies varying in efficacy and costs, no clinical or economic studies directly co...
Citation: BMC Medicine 2020 18:378
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