Skip to main content

Advertisement

Articles

Page 1 of 47

  1. Brain innate immunity is vital for maintaining normal brain functions. Immune homeostatic imbalances play pivotal roles in the pathogenesis of neurological diseases including Parkinson’s disease (PD). However,...

    Authors: Shu-zhen Zhang, Qin-qin Wang, Qiao-qiao Yang, Huan-yu Gu, Yan-qing Yin, Yan-dong Li, Jin-can Hou, Rong Chen, Qing-qing Sun, Ying-feng Sun, Gang Hu and Jia-wei Zhou

    Citation: BMC Medicine 2019 17:204

    Content type: Research article

    Published on:

  2. Childhood adversity (CA) is strongly associated with mental health problems. Resilience factors (RFs) reduce mental health problems following CA. Yet, knowledge on the nature of RFs is scarce. Therefore, we ex...

    Authors: J. Fritz, J. Stochl, E. I. Fried, I. M. Goodyer, C. D. van Borkulo, P. O. Wilkinson and A.-L. van Harmelen

    Citation: BMC Medicine 2019 17:203

    Content type: Research article

    Published on:

  3. It is not known whether segmentation of an in vitro fertilisation (IVF) cycle, with freezing of all embryos prior to transfer, increases the chance of a live birth after all embryos are transferred.

    Authors: Andrew D. A. C. Smith, Kate Tilling, Deborah A. Lawlor and Scott M. Nelson

    Citation: BMC Medicine 2019 17:202

    Content type: Research article

    Published on:

  4. Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatmen...

    Authors: Peter Hanlon, Laurie Hannigan, Jesus Rodriguez-Perez, Colin Fischbacher, Nicky J. Welton, Sofia Dias, Frances S. Mair, Bruce Guthrie, Sarah Wild and David A. McAllister

    Citation: BMC Medicine 2019 17:201

    Content type: Research article

    Published on:

  5. Niemann–Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therape...

    Authors: Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman…

    Citation: BMC Medicine 2019 17:200

    Content type: Research article

    Published on:

  6. The role of aspirin in primary prevention of cardiovascular disease (CVD) remains unclear. We aimed to investigate the benefit-risk ratio of aspirin for primary prevention of CVD with a particular focus on sub...

    Authors: Georg Gelbenegger, Marek Postula, Ladislav Pecen, Sigrun Halvorsen, Maciej Lesiak, Christian Schoergenhofer, Bernd Jilma, Christian Hengstenberg and Jolanta M. Siller-Matula

    Citation: BMC Medicine 2019 17:198

    Content type: Research article

    Published on:

  7. Dyslipidemia and inflammation are closely interrelated contributors in the pathogenesis of atherosclerosis. Disorders of lipid metabolism initiate an inflammatory and immune-mediated response in atherosclerosi...

    Authors: Ruurt A. Jukema, Tarek A. N. Ahmed and Jean-Claude Tardif

    Citation: BMC Medicine 2019 17:197

    Content type: Opinion

    Published on:

  8. Periconceptional folic acid prevents neural tube defects (NTDs), but it is uncertain whether there are benefits for offspring neurodevelopment arising from continued maternal folic acid supplementation beyond ...

    Authors: Helene McNulty, Mark Rollins, Tony Cassidy, Aoife Caffrey, Barry Marshall, James Dornan, Marian McLaughlin, Breige A. McNulty, Mary Ward, J. J. Strain, Anne M. Molloy, Diane J. Lees-Murdock, Colum P. Walsh and Kristina Pentieva

    Citation: BMC Medicine 2019 17:196

    Content type: Research article

    Published on:

  9. Artificial intelligence (AI) research in healthcare is accelerating rapidly, with potential applications being demonstrated across various domains of medicine. However, there are currently limited examples of ...

    Authors: Christopher J. Kelly, Alan Karthikesalingam, Mustafa Suleyman, Greg Corrado and Dominic King

    Citation: BMC Medicine 2019 17:195

    Content type: Opinion

    Published on:

  10. Age-related frailty is a multidimensional dynamic condition associated with adverse patient outcomes and high costs for health systems. Several interventions have been proposed to tackle frailty. This correspo...

    Authors: Maura Marcucci, Sarah Damanti, Federico Germini, Joao Apostolo, Elzbieta Bobrowicz-Campos, Holly Gwyther, Carol Holland, Donata Kurpas, Maria Bujnowska-Fedak, Katarzyna Szwamel, Silvina Santana, Alessandro Nobili, Barbara D’Avanzo and Antonio Cano

    Citation: BMC Medicine 2019 17:193

    Content type: Correspondence

    Published on:

  11. Clinical prediction models are useful in estimating a patient’s risk of having a certain disease or experiencing an event in the future based on their current characteristics. Defining an appropriate risk thre...

    Authors: Laure Wynants, Maarten van Smeden, David J. McLernon, Dirk Timmerman, Ewout W. Steyerberg and Ben Van Calster

    Citation: BMC Medicine 2019 17:192

    Content type: Opinion

    Published on:

  12. Socioeconomic status (SES) is associated with stroke incidence and mortality. Distribution of stroke risk factors is changing worldwide; evidence on these trends is crucial to the allocation of resources for p...

    Authors: Abolfazl Avan, Hadi Digaleh, Mario Di Napoli, Saverio Stranges, Reza Behrouz, Golnaz Shojaeianbabaei, Amin Amiri, Reza Tabrizi, Naghmeh Mokhber, J. David Spence and Mahmoud Reza Azarpazhooh

    Citation: BMC Medicine 2019 17:191

    Content type: Research article

    Published on:

  13. In locoregionally advanced nasopharyngeal carcinoma (LANPC) patients, variance of tumor response to induction chemotherapy (ICT) was observed. We developed and validated a novel imaging biomarker to predict wh...

    Authors: Di Dong, Fan Zhang, Lian-Zhen Zhong, Meng-Jie Fang, Cheng-Long Huang, Ji-Jin Yao, Ying Sun, Jie Tian, Jun Ma and Ling-Long Tang

    Citation: BMC Medicine 2019 17:190

    Content type: Research article

    Published on:

  14. There is growing interest in evaluating differences in healthcare interventions across routinely collected demographic characteristics. However, individual subgroup analyses in randomized controlled trials are...

    Authors: Patrick Liu, John P. A. Ioannidis, Joseph S. Ross, Sanket S. Dhruva, Anita T. Luxkaranayagam, Vasilis Vasiliou and Joshua D. Wallach

    Citation: BMC Medicine 2019 17:188

    Content type: Research article

    Published on:

  15. Customized birth weight charts take into account physiological maternal characteristics that are known to influence fetal growth to differentiate between physiological and pathological abnormal size at birth. ...

    Authors: Jan S. Erkamp, Vincent W. V. Jaddoe, Annemarie G. M. G. J. Mulders, Eric A. P. Steegers, Irwin K. M. Reiss, Liesbeth Duijts and Romy Gaillard

    Citation: BMC Medicine 2019 17:186

    Content type: Research article

    Published on:

  16. The current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed as t...

    Authors: Tobias Klatte, Kevin M. Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger, Silvia Ribback, Alan McNeill, Antony C. P. Riddick, James N. Armitage, Tevita F. ‘Aho, Tim Eisen, Kate Fife, Axel Bex, Allan J. Pantuck and Grant D. Stewart

    Citation: BMC Medicine 2019 17:182

    Content type: Research article

    Published on:

  17. The identification of individuals at increased risk of poor health-related outcomes is a priority. Geriatric research has proposed several indicators shown to be associated with these outcomes, but a head-to-h...

    Authors: Alberto Zucchelli, Davide L. Vetrano, Giulia Grande, Amaia Calderón-Larrañaga, Laura Fratiglioni, Alessandra Marengoni and Debora Rizzuto

    Citation: BMC Medicine 2019 17:185

    Content type: Research article

    Published on:

  18. The healthcare system can be understood as the dynamic result of the interaction of hospitals, patients, providers, and government configuring a complex network of reciprocal influences. In order to better und...

    Authors: Felix Rigoli, Sergio Mascarenhas, Domingos Alves, Tiago Canelas and Geraldo Duarte

    Citation: BMC Medicine 2019 17:184

    Content type: Research article

    Published on:

  19. Please see related article: https://​doi.​org/​10.​1186/​s12916-019-1410-x

    Authors: Megan Wilson-Jones, Kyla Smith, Dan Jones, Helen Hamilton, Leah Richardson, Alison Macintyre, Om Prasad Gautam, Erik Harvey and Henry Northover

    Citation: BMC Medicine 2019 17:183

    Content type: Commentary

    Published on:

    The original article was published in BMC Medicine 2019 17:173

  20. Vaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can ...

    Authors: Sebastian Funk, Jennifer K. Knapp, Emmaculate Lebo, Susan E. Reef, Alya J. Dabbagh, Katrina Kretsinger, Mark Jit, W. John Edmunds and Peter M. Strebel

    Citation: BMC Medicine 2019 17:180

    Content type: Research Article

    Published on:

  21. Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in...

    Authors: Mathilde His, Vivian Viallon, Laure Dossus, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Pietro Ferrari, Isabelle Romieu, N. Charlotte Onland-Moret, Elisabete Weiderpass, Christina C. Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Agnès Fournier, Joseph A. Rothwell…

    Citation: BMC Medicine 2019 17:178

    Content type: Research article

    Published on:

  22. BMC Medicine was launched in November 2003 as an open access, open peer-reviewed general medical journal that has a broad remit to publish “outstanding and influential research in all areas of clinical practice, ...

    Authors: Deborah A. Lawlor

    Citation: BMC Medicine 2019 17:177

    Content type: Correspondence

    Published on:

  23. We have previously demonstrated in the DIABRISK-SL trial that a trimonthly pragmatic lifestyle modification (P-LSM), as compared to a 12-monthly LSM advice (C-LSM), significantly reduced the primary composite ...

    Authors: Nikolaos Fountoulakis, Mahen Wijesuriya, Luigi Gnudi, Martin Gulliford and Janaka Karalliedde

    Citation: BMC Medicine 2019 17:162

    Content type: Correspondence

    Published on:

    The original article was published in BMC Medicine 2019 17:121

    The original article was published in BMC Medicine 2017 15:146

  24. The introduction of highly effective direct-acting antiviral (DAA) therapy for hepatitis C has led to calls to eliminate it as a public health threat through treatment-as-prevention. Recent studies suggest it ...

    Authors: Nick Scott, David P. Wilson, Alexander J. Thompson, Eleanor Barnes, Manal El-Sayed, Adele Schwartz Benzaken, Heidi E. Drummer and Margaret E. Hellard

    Citation: BMC Medicine 2019 17:175

    Content type: Research article

    Published on:

  25. Different methodological choices such as inclusion/exclusion criteria and analytical models can yield different results and inferences when meta-analyses are performed. We explored the range of such difference...

    Authors: Clément Palpacuer, Karima Hammas, Renan Duprez, Bruno Laviolle, John P. A. Ioannidis and Florian Naudet

    Citation: BMC Medicine 2019 17:174

    Content type: Research article

    Published on:

  26. Wolbachia-infected mosquitoes reduce dengue virus transmission, and city-wide releases in Yogyakarta city, Indonesia, are showing promising entomological results. Accurate estimates of the burden of dengue, its s...

    Authors: Kathleen M. O’Reilly, Emilie Hendrickx, Dinar D. Kharisma, Nandyan N. Wilastonegoro, Lauren B. Carrington, Iqbal R. F. Elyazar, Adam J. Kucharski, Rachel Lowe, Stefan Flasche, David M. Pigott, Robert C. Reiner Jr, W. John Edmunds, Simon I. Hay, Laith Yakob, Donald S. Shepard and Oliver J. Brady

    Citation: BMC Medicine 2019 17:172

    Content type: Research article

    Published on:

  27. The epidemiology of CNS infections in Europe is dynamic, requiring that clinicians have access to up-to-date clinical management guidelines (CMGs) to aid identification of emerging infections and for improving...

    Authors: Louise Sigfrid, Chelsea Perfect, Amanda Rojek, Kajsa-Stina Longuere, Sam Lipworth, Eli Harriss, James Lee, Alex Salam, Gail Carson, Herman Goossens and Peter Horby

    Citation: BMC Medicine 2019 17:170

    Content type: Research article

    Published on:

  28. Diagnostic codes from electronic health records are widely used to assess patterns of disease. Infective endocarditis is an uncommon but serious infection, with objective diagnostic criteria. Electronic health...

    Authors: Nicola Fawcett, Bernadette Young, Leon Peto, T. Phuong Quan, Richard Gillott, Jianhua Wu, Chris Middlemass, Sheila Weston, Derrick W. Crook, Tim E. A. Peto, Berit Muller-Pebody, Alan P. Johnson, A. Sarah Walker and Jonathan A. T. Sandoe

    Citation: BMC Medicine 2019 17:169

    Content type: Research article

    Published on:

  29. Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is u...

    Authors: Tao Huang, Shoaib Afzal, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Ningyu Chen, Ruqin Gao, Junshi Chen, Robert Clarke, Zhengming Chen, Christina Ellervik, Børge G. Nordestgaard…

    Citation: BMC Medicine 2019 17:160

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2019 17:166

  30. Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only ...

    Authors: Oliver Cumming, Benjamin F. Arnold, Radu Ban, Thomas Clasen, Joanna Esteves Mills, Matthew C. Freeman, Bruce Gordon, Raymond Guiteras, Guy Howard, Paul R. Hunter, Richard B. Johnston, Amy J. Pickering, Andrew J. Prendergast, Annette Prüss-Ustün, Jan Willem Rosenboom, Dean Spears…

    Citation: BMC Medicine 2019 17:173

    Content type: Opinion

    Published on:

  31. The alpha-adrenergic agonist phenylephrine is often used to treat hypotension during anesthesia. In clinical situations, low blood pressure may require prompt intervention by intravenous bolus or infusion. Dif...

    Authors: Yanfei Zhang, S. Mark Poler, Jiang Li, Vida Abedi, Sarah A. Pendergrass, Marc S. Williams and Ming Ta Michael Lee

    Citation: BMC Medicine 2019 17:168

    Content type: Research article

    Published on:

  32. The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to the genetic architecture of diabetes.

    Authors: Paul M. McKeigue, Athina Spiliopoulou, Stuart McGurnaghan, Marco Colombo, Luke Blackbourn, Timothy J. McDonald, Suna Onengut-Gomuscu, Stephen S. Rich, Colin N. A. Palmer, John A. McKnight, Mark W. J. Strachan, Alan W. Patrick, John Chalmers, Robert S. Lindsay, John R. Petrie, Sandeep Thekkepat…

    Citation: BMC Medicine 2019 17:165

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2019 17:179

  33. Despite the increasing popularity of multi-model comparison studies and their ability to inform policy recommendations, clear guidance on how to conduct multi-model comparisons is not available. Herein, we pre...

    Authors: Saskia den Boon, Mark Jit, Marc Brisson, Graham Medley, Philippe Beutels, Richard White, Stefan Flasche, T. Déirdre Hollingsworth, Tini Garske, Virginia E. Pitzer, Martine Hoogendoorn, Oliver Geffen, Andrew Clark, Jane Kim and Raymond Hutubessy

    Citation: BMC Medicine 2019 17:163

    Content type: Guideline

    Published on:

  34. Cannabis is the most commonly used illicit substance amongst people with psychosis. Continued cannabis use following the onset of psychosis is associated with poorer functional and clinical outcomes. However, ...

    Authors: Luke Sheridan Rains, Louise Marston, Mark Hinton, Steven Marwaha, Thomas Craig, David Fowler, Michael King, Rumana Z. Omar, Paul McCrone, Jonathan Spencer, Joanne Taylor, Sophie Colman, Catherine Harder, Eleanor Gilbert, Amie Randhawa, Kirsty Labuschagne…

    Citation: BMC Medicine 2019 17:161

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2019 17:194

  35. Vaccination and naturally acquired immunity against microbial pathogens may have complex interactions that influence disease outcomes. To date, only vaccine-specific immune responses have routinely been invest...

    Authors: Carlota Dobaño, Itziar Ubillos, Chenjerai Jairoce, Ben Gyan, Marta Vidal, Alfons Jiménez, Rebeca Santano, David Dosoo, Augusto J. Nhabomba, Aintzane Ayestaran, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, David Lanar, Virander Chauhan, Chetan Chitnis…

    Citation: BMC Medicine 2019 17:157

    Content type: Research article

    Published on:

  36. The optimal dose of rabbit antithymocyte globulin (ATG, ImtixSangstat) minimizing infections without increasing graft-versus-host disease (GVHD) is unknown in T cell-replete, G-CSF-primed haploidentical hemato...

    Authors: Ren Lin, Yu Wang, Fen Huang, Zhiping Fan, Shen Zhang, Ting Yang, Yajing Xu, Na Xu, Li Xuan, Jieyu Ye, Jing Sun, Xiaojun Huang and Qifa Liu

    Citation: BMC Medicine 2019 17:156

    Content type: Research article

    Published on:

  37. The original article [1] contained an error in the abstract. The mentioned cohort size now correctly states ‘N = 3,855,660’.

    Authors: Alexander Pate, Richard Emsley, Darren M. Ashcroft, Benjamin Brown and Tjeerd van Staa

    Citation: BMC Medicine 2019 17:158

    Content type: Correction

    Published on:

    The original article was published in BMC Medicine 2019 17:134

  38. Antibiotic-induced disturbances of the human microbiota have been implicated in the development of chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with the onset ...

    Authors: Alyshah Abdul Sultan, Christian Mallen, Sara Muller, Samantha Hider, Ian Scott, Toby Helliwell and Lindsay J. Hall

    Citation: BMC Medicine 2019 17:154

    Content type: Research article

    Published on:

  39. India and many other high-burden countries have committed to providing universal access to high-quality diagnosis and drug susceptibility testing (DST) for tuberculosis (TB), but the most cost-effective approa...

    Authors: Hojoon Sohn, Parastu Kasaie, Emily Kendall, Gabriela B. Gomez, Anna Vassall, Madhukar Pai and David Dowdy

    Citation: BMC Medicine 2019 17:155

    Content type: Research article

    Published on:

  40. Pregnant women are highly susceptible to anaemia and iron deficiency due to the increased demands of pregnancy as well as other factors. Iron supplementation is recommended in pregnancy, yet the benefits on ne...

    Authors: Freya J. I. Fowkes, Eliza Davidson, Paul A. Agius and James G. Beeson

    Citation: BMC Medicine 2019 17:153

    Content type: Correspondence

    Published on:

    The original article was published in BMC Medicine 2019 17:146

Advertisement