Reasons for exclusion | n |
---|---|
Lack of placebo-controlled, double-blind, randomized trial | Â |
   Review, article, or comment | 272 |
   No placebo used | 186 |
   Lack of double-blinding or randomization | 96 |
Kind of investigated symptom or condition | Â |
   No clinical condition | 44 |
   Psychological, neurological or psychiatric condition | 106 |
   Subjective symptom | 67 |
No classic placebo control group | Â |
   Placebo as a dummy to maintain blinding of experimental treatments | 147 |
   Placebo as a control of an add-on treatment | 74 |
Lack of stable disease condition | Â |
   Medical intervention preceding experimental treatment | 120 |
   Co-medication changed during study | 33 |
   Acute condition | 79 |
   Developmental disorder | 20 |
   Trial focus on relapse or prevention | 131 |
   Trial focus on death or other serious events | 113 |
   Trial focus on long-term development of disease | 121 |
Miscellaneous | Â |
   Crossover design and results not separated by sequence | 23 |
   Native physiological parameter not reported | 17 |
   Insufficient detail to estimate placebo effect | 40 |
Total | 1689 |