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Table 3 Tests of association between SNPs and CAD using FBAT.

From: An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

Chromosome

Gene

SNP

RS number

MAF

P-value *

1p32-p31

VCAM1

T707C

1041163

0.16

0.39

1q21-24

SELP

G40A

6131

0.18

0.84

  

G75271T

6133

0.14

0.67

1q22-q25

SELE

A153C

5361

0.11

0.33

1q31-32

IL10

C8700A

1800872

0.24

0.29

2q12-q21

IL1α

C549T

1800587

0.31

0.08

2q14

IL1β

C4336T

1143634

0.26

0.58

  

C1423T

16944

0.34

0.49

2q33

CTLA4

C875T

5742909

0.10

0.34

2q33

CTLA4

A1241G

231775

0.40

0.68

3p21

CCR2

G46295A

1799864

0.08

0.88

3p21

CCR5

Wt/del 580-611

333

0.14

0.72

  

G59029A

1799987

0.44

0.33

3p21.3

CCR3

C320T

5742906

0.01

- †

3p26-p24

IL5RA

G482A

2290608

0.28

0.10

4q12-q13

GC

G35706T

7041

0.44

0.50

 

GC

C35717A

4588

0.29

0.21

5q22-32

CD14

C2232T

2569190

0.47

0.63

5q23-q31

IL4

C582T

2243250

0.14

0.66

5q31

IL13

C4045T

1295686

0.20

0.78

5q31

TCF7

C883A

5742913

0.12

0.35

5q31.1

TCF7

A383T

25882

0.14

0.49

5q31.1

CSF2

T2600C

244656

0.22

0.16

5q31-q32

ADRB2

A1633G

1042713

0.37

0.91

  

C1666G

1042714

0.42

0.37

  

C2078T

1800888

0.02

- †

5q31-q35

IL9

C4244T

2069885

0.13

0.01 (T)

5q35

LTC4S

A620C

730012

0.31

0.22

6p21.3

LTA

A1069G

909253

0.39

0.60

 

TNF

G3787A

1800629

0.21

0.34

  

G3857A

361525

0.07

0.99

7p21-p15

IL6

G589C

1800796

0.06

0.33

  

G987C

1800795

0.43

0.38

7q35-q36

NOS3

A498G

1800779

0.40

0.05 (G)

  

G7002T

1799983

0.36

0.67

9q32-q34

C5

A2416G

17611

0.44

0.04 (G)

10q11.1

SDF1

G880A

1801157

0.20

0.84

11q11-qter

UGB

G587A

3741240

0.36

0.65

11q13

FCERB1

A7297G

569108

0.03

0.48

12q13.1

VDR

T12022C

2228570

0.40

0.77

  

G45082A

1544410

0.42

0.61

16p11.2-p12.1

IL4R

A398G

1805010

0.46

0.56

  

T1682C

1805015

0.20

0.01 (C)

  

A1902G

1801275

0.25

0.04 (G)

17q11.2-q12

NOS2A

C231T

1137933

0.23

0.98

17q21.1-q21.2

SCYA11

G361A

3744508

0.19

0.04 (G)

  

G1169A

4795895

0.20

0.47

19q13.1

TGFB1

C629T

1800469

0.27

- ‡

19p13.2

ICAM1

A120T

5491

0.001

- ‡

  

G657A

1799969

0.12

0.43

19p13.3-p13.2

C3

C364G

2230199

0.24

0.39

  1. * In parenthesis after the P-value: the allele associated with an increased disease risk.
  2. † Number of informative families below 50.
  3. ‡ Not in Hardy-Weinberg equilibrium.
  4. MAF, minor allele frequency; SNP, single nucleotide polymorphism; CAD, coronary artery disease.
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BMC Medicine

ISSN: 1741-7015

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