Table 3 Odds ratios for breast cancer according to cumulative SSRI dose during exposure time windows
Exposure time window a | Total SSRI dosage b (mg) | Cases (n = 1,701) | Controls (n = 17,017) | Unadjusted OR c (95% CI) | Adjusted OR d (95% CI) | ||
|---|---|---|---|---|---|---|---|
n | (%) | n | (%) | ||||
≥2 years | No use e (reference) | 1,442 | (84.8) | 14,415 | (84.7) | 1.00 | 1.00 |
1 to 27, 750 mg | 222 | (13.1) | 2,198 | (12.9) | 1.01 (0.87, 1.17) | 1.01 (0.87, 1.17) | |
≥27, 750 mg | 37 | (2.2) | 404 | (2.4) | 0.92 (0.65, 1.29) | 0.91 (0.64, 1.28) | |
2 to 7 years | No use e (reference) | 1,512 | (88.9) | 15,122 | (88.9) | 1.00 | 1.00 |
1 to 25, 365 mg | 161 | (9.5) | 1,594 | (9.4) | 1.01 (0.85, 1.20) | 1.01 (0.85, 1.20) | |
≥25, 365 mg | 28 | (1.7) | 301 | (1.8) | 0.93 (0.63, 1.38) | 0.92 (0.62, 1.36) | |
>7 years | No use e (reference) | 1,558 | (91.6) | 15,475 | (90.9) | 1.00 | 1.00 |
1 to 20, 340 mg | 118 | (6.9) | 1,303 | (7.7) | 0.90 (0.74, 1.09) | 0.90 (0.74, 1.09) | |
≥20, 340 mg | 25 | (1.5) | 239 | (1.4) | 1.04 (0.69, 1.57) | 1.02 (0.67, 1.55) | |