A functional tandem-repeats polymorphism in the downstream of TERTis associated with the risk of nasopharyngeal carcinoma in Chinese population

Table 2 Risk of nasopharyngeal carcinoma associated with MNS16A by potential risk factors

Category	LL ^a,b	SL+ SS ^a,b	OR (95% CI)^c,d	P ^e	P _homogeneity ^f
Age, years					0. 55
< 45	331/448	34/60	0. 78 (0. 50 to 1. 22)	0. 19
≥ 45	394/438	39/68	0. 65 (0. 43 to 0. 98)	0. 051
Gender					0. 24
Male	525/646	44/88	0. 61 (0. 42 to 0. 90)	0. 0090
Female	200/245	29/40	0. 90 (0. 54 to 1. 51)	0. 61
Tobacco use					0. 11
Nonsmoker	502/624	56/85	0. 82 (0. 57 to 1. 18)	0. 28
Smoker	223/267	17/43	0. 47 (0. 26 to 0. 85)	0. 0090
Smoking level (pack-years)					0. 34
< 24	635/787	65/109	0. 74 (0. 53 to 1. 03)	0. 071
≥ 24	90/104	8/19	0. 47 (0. 20 to 1. 13)	0. 080
Alcohol use					0. 39
Non-drinker	509/630	55/89	0. 76 (0. 53 to 1. 09)	0. 13
Drinker	217/261	18/39	0. 56 (0. 31 to 1. 02)	0. 032
Ethnicity					0. 77
Han	541/776	57/112	0. 72 (0. 52 to 1. 02)	0. 064
Non-Han	184/115	16/16	0. 67 (0. 30 to 1. 50)	0. 67
Family history^f					0. 70
Negative	678/862	71/127	0. 69 (0. 51 to 0. 95)	0. 022
Positive	47/29	2/1	1. 12 (0. 09 to 13. 26)	0. 88

^aOwing to genotyping failure, the actual sample size was 798 and 1019 for the cases and controls, respectively.
^bNumber of genotype in cases/number of genotype in controls. L allele, 302 or 333 bp; S allele, 243 or 272 bp.
^cThe odds ratios (ORs) and P values were calculated by logistic regression with LL genotype as the reference group and adjusted for age, gender, tobacco and alcohol status, smoking level, ethnicity and family history where appropriate within the strata.
^dConfidence interval
^eFor difference in ORs within each stratum.
^fFirst-degree relatives

ISSN: 1741-7015