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Table 2 Baseline Demographic and Clinical Characteristics Comparing ASA Low Responder and Responder

From: Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance - The BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy

Variable

ASA Low-Responder

ASA Responder

OR (95% CI)

p-Value

No. (%)

78 (19.4)

325 (80.6)

  

Female gender (%)

19 (24.4)

101 (31.1)

0.71 (0.40-1.26)

n.s. (0.27)

Age (years)

63.80 (12.90)

64.30 (11.70)

 

n.s. (0.74)

BMI (kg/m2)

28.17 (5.10)

27.81 (4.30)

 

n.s. (0.52)

EF (%)

52.78 (13.90)

54.35 (11.10)

 

n.s. (0.29)

Acute coronary syndrome

61 (78.2)

211 (64.9)

1.94 (1.08-3.48)

0.03

Arterial hypertension

62 (79.5)

258 (79.4)

1.01 (0.54-1.86)

n.s. (1.0)

Diabetes mellitus

38 (48.7)

113 (34.8)

1.78 (1.08-2.94)

0.03

Lipid disorder

44 (56.4)

193 (59.4)

0.89 (0.54-1.46)

n.s. (0.70)

Cigarette smoking

33 (42.3)

148 (45.5)

0.88 (0.53-1.45)

n.s. (0.62)

Familial CAD disposition

10 (12.8)

68 (20.9)

0.56 (0.27-1.14)

n.s. (0.11)

Beta-Blockers

71 (91.0)

279 (85.8)

1.67 (0.72-3.86)

n.s. (0.27)

Nitrates

8 (10.3)

71 (21.8)

0.41 (0.19-0.89)

0.03

Calcium-channel blockers

25 (32.0)

90 (27.7)

1.23 (0.72-2.10)

n.s. (0.49)

ACE Inhibitors

67 (85.9)

276 (84.9)

1.08 (0.53-2.19)

n.s. (1.0)

Diuretics

39 (50.0)

124 (38.2)

1.62 (0.99-2.67)

n.s. (0.07)

Statins

58 (74.4)

257 (79.1)

0.77 (0.43-1.36)

n.s. (0.36)

Proton pump inhibitors

29 (37.2)

147 (45.2)

0.72 (0.43-1.19)

n.s. (0.21)

Number of drugs (n ± SD)

7.50 (2.80)

7.48 (2.20)

1.67 (0.72-3.86)

n.s. (0.95)

WBC (×109/l)

9.80 (4.10)

8.70 (5.40)

 

0.09

Hemoglobin (g/dl)

14.71 (2.40)

14.07 (1.50)

 

0.003

Platelet count (×109/l)

250.33 (10.22)

205.80 (63.69)

 

<0.001

Troponin positive (%)

34 (43.6)

53 (16.3)

3.97 (2.32-6.78)

<0.001

CK max (U/l)

478.15 (1508.40)

529.77 (638.70)

 

n.s. (0.64)

Total cholesterol (mg/dl)

205.63 (60.60)

202.14 (51.30)

 

n.s. (0.60)

CRP (mg/l)

12.26 (21.40)

7.22 (15.40)

 

0.02

HbA1C (%)

6.88 (1.70)

6.41 (1.30)

 

0.007

D-dimer (mg/l)

0.78 (0.60)

1.02 (2.70)

 

n.s. (0.44)

Serum creatinine (mg/dl)

1.14 (0.80)

1.02 (0.30)

 

0.03

GFR (MDRD) (ml/min)

81.50 (59.70)

78.16 (22.30)

 

n.s. (0.42)

PREDICT score

3.39 (2.20)

2.55 (1.80)

 

<0.001

Clopidogrel low-response

44 (56.4)

74 (22.8)

4.39 (2.62-7.36)

<0.001

  1. Data presented are mean ± SD and count (no.) or percentage (%). Calculation of p-values was done by unpaired t-test or chi-square test, comparing low-responder versus responder. OR = odds ratio; CI = confidence interval; n.s. = not significant.
  2. ASA = acetylsalicylic acid (aspirin), BMI = body mass index, EF = ejection fraction, CAD = coronary artery disease, ACE = angiotensin-converting enzyme, WBC = white blood cells, CK = creatine kinase, CRP = C-reactive protein, HbA1C = hemoglobin A1c, GFR = glomerular filtration rate.
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BMC Medicine

ISSN: 1741-7015

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