Technique | Target | Use |
---|---|---|
18F-DOPA PET | Aromatic amino acid decarboxylase (AADC) | Provides measures of AADC activity and allows an indirect measure of DA storage within the DA terminals. |
11C-raclopride PET | Post-synaptic DA D2 receptors | Is a subject to competitive displacement by endogenous DA. Acute administration of substances such as amphetamine, methylphenidate, or L-DOPA, which are known to increase the levels of extracellular DA result in a reduction of 11C-raclopride binding. |
H2 15O PET | Regional cerebral blood flow (rCBF) | Brain activation and regional cerebral metabolism. |
76Br-FE-CBT PET | Dopamine transporter (DAT) | Marker of presynaptic DA terminals integrity and DAT availability |
123I-IPT SPECT | DAT | Marker of presynaptic DA terminals integrity and DAT availability |
123I-FP-CIT SPECT | DAT | Marker of presynaptic DA terminals integrity and DAT availability |
11C-PK11195 PET | Translocator protein (TSPO) | Is an 18 kDa protein of the outer mitochondrial membrane that is upregulated with activation of microglia |
11C-DASB PET | 5-HT transporter (SERT) | Marker of presynaptic 5-HT terminals integrity and SERT availability |
11C-dihydrotetrabenazine (DTBZ) PET | Vesicular monoamine transporter (VMAT2) | Marker of presynaptic monoaminergic terminals integrity |