From: The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Mitochondrial abnormality | MS | CFS | PD | AUT | MDD | Schiz | BPD |
---|---|---|---|---|---|---|---|
Ultrastructural abnormalities in mitochondria | + | ++ | + | + | + | +++ | + |
Evidence to shift in energy production via glycolysis | + | ++ | ++ | ++ | Â | ++ | ++ |
Mitochondrial dysfunction in peripheral immune cells | + | ++ | ++ | ++ | ++ | ++ | + |
Mitochondria DNA damage | + | Â | Â | Â | Â | ++ | Â |
Damage to the electron transport chain | ++ | Â | +++ | + | Â | ++ | + |
High lactate in brain or cerebrospinal fluid | + | + | + | + | + | ++ | + |
Bioenergetic impairment Skeletal muscle | Â | +++ | Â | Â | + | Â | Â |
Decreased mitochondrial membrane potential | Â | + | + | Â | Â | Â | Â |