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Table 2 The Sepsis Six and Red Flag Sepsis, clinical tools from the UK Sepsis Trust

From: Recognizing and managing sepsis: what needs to be done?

Sepsis Six Red Flag Sepsis
1 High-flow oxygen Systolic BP <90 mmHg or MAP <65 mmHg
2 Blood cultures and consider source control Lactate >2 mmol/L
3 Intravenous antibiotics Heart rate >130 per minute
4 Intravenous fluid resuscitation Respiratory rate >25 per minute
5 Check hemoglobin and serial lactates Oxygen saturations <91%
6 Hourly urine output measurement Responds only to voice or pain/unresponsive
Purpuric rash
An immediate care bundle to be delivered within one hour for patients with sepsis A risk stratification tool for patients with possible sepsis