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Table 3 Accuracy characteristics of microRNAs in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples

From: Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma

microRNA

PPV

NPV

Accuracy

AUC (95% CI)

% (95% CI)

% (95% CI)

% (95% CI)

FFPE samples

miR-200a

100 (82.2–100.0)

68.4 (43.5–87.3)

84.2 (68.1–93.4)

0.92 (0.83–0.99)

miR-200c

100 (84.4–100.0)

81.2 (54.34–95.73)

92.1 (77.5–97.9)

0.94 (0.85–1.0)

miR-203

100 (86.2–100)

100 (75.1–100)

100 (88.6–100)

1.0 (0–1.0)

miR-205

100 (86.2–100)

100 (75.1–100)

100 (88.6–100)

1.0 (0–1.0)

FNA samples classified by cytology

miR-203

100 (91.5–100)

100 (94.9–100)

100 (96.05–100)

1.0 (0–1.0)

miR-205

100 (91.5–100)

100 (94.9–100)

100 (96.05–100)

1.0 (0–1.0)

FNA samples classified by histology

miR-203

100 (90.9–100)

95.9 (88.6–99.1)

97.3 (92.1–99.4)

0.963 (0.921–1.0)

miR-205

100 (93.2–100)

94.6 (85.1–98.8)

96.7 (93.1–100)

0.966 (0.921–1.0)

  1. FFPE, Formalin-fixed paraffin embedded; FNA, Fine-needle aspiration; PPV, Positive predictive value; NPV, Negative predictive value; AUC, Area under the ROC curve; CI, Confidence interval.