Table 1 Characteristics and methodological aspects of studies included in the meta-analysis/systematic review
Study (year) | Country | Ethnicity | No. of patients | Clinical set | Menopausal status | Aromatase inhibitors | Main SNPsa/haplotypes (total analyzed) | Main outcomesb |
|---|---|---|---|---|---|---|---|---|
Fontein et al. [39] | Netherlands | C | 737 | Adj | Post-menopausal | E | rs934635, rs1694189, rs7176005 (30) | AE (MS-AI, VMS) |
Liu et al. [24] | China | As | 272 | ABC | NR | A | rs10046, rs4646 (2) | OS, TTP, AE |
Miron et al. [40] | Italy | C | 53 | NR | NR | A, E, L | rs10046, rs4646, rs727479, rs700518 (4) | DFS, OS, TTP |
Napoli et al. [38] | USA | C (80 %), B (19 %), As (1 %) | 101 | BC Stage 0-III | Post-menopausal | A, E, L | rs4646, rs700518, rs1062033 (3) | AE (MS-AI) |
Ghimenti et al. [34] | Italy | C | 37 | Neoadj | Post-menopausal | A | rs7176005, rs6493497 (2) | CR (RECIST) |
Ferraldeschi et al. [41] | UK | C (90 %), others (10 %) | 308 | ABC | NR | A, E, L | rs4775936, rs60271534, rs10459592, rs11636639, rs8039089 (56) | TTF |
Park et al. [21] | Korea | As | 109 | ABC | Pre-/post-menopausal | L | rs700518, rs10459592, rs4775936 (46) * Haplotypes: M_1_3, M_2_1, M_3_5, M_5_3 (8) | CR (RECIST), TTP, AE (hot flushes), AE (MS-AI) |
Mao et al. [37] | USA | C | 390 | Adjuvant BC Stage 0-III | Post-menopausal | A, E, L | rs749292, rs727479, rs10046, rs11575899, rs60271534 (5) | AE (MS-AI) |
Garcia-Casado et al. [35] | Spain | C | 95 | Neoadj | Post-menopausal | L | rs10046, rs4646, rs700519 (3) | CR (WHO), PFS |
Wang et al. [33] | USA, UK | C | 45 | Neoadj | NR | A, E, L | rs6493497, rs7176005 (48) | Tumor size |
Colomer et al. [20] | Spain | C | 67 | ABC | Post-menopausal | L | rs10046, rs4646, rs727479 (3) | TTP, AE, CR (RECIST) |
Henry et al. [36] | USA | C (88 %), B (9 %) | 432 | Adj | Post-menopausal | E, L | rs10046, rs1008805, rs10459592, rs1062033, rs11575899, rs2008691, rs2289105, rs2414096, rs28566535, rs28757184, rs3759811, rs4646, rs4774585, rs4775936, rs6493497, rs700518, rs7181886, rs727479, rs730154, rs749292, rs752760, rs936308, rs60271534 (24*) | AE (MS-AI), treatment discontinuation |