Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies

Table 4 Impact of potential confounders on changes in plaque volume following statin therapy in random-effects meta-regression

Confounder	Slope	95 % CI	P value
Age (years)	0.009	−0.020, 0.039	0.537
% Males	−0.011	−0.024, 0.002	0.106
% Diabetics	0.003	−0.002, 0.008	0.255
% Smokers	−0.004	−0.009, 0.0004	0.075
Dose (mg/day)^a	−0.007	−0.015, 0.001	0.091
Baseline LDL-C (mg/dL)	0.004	−0.007, 0.016	0.435

^aRestricted to atorvastatin trials. CI, confidence interval; LDL-C, low-density lipoprotein cholesterol

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