Table 1 Characteristics of development and validation cohorts for those aged 60–79 years (before multiple imputation)
|  | Development cohort n = 800,013 Median follow-up 5 years (IQR, 3.15–5 years) Dementia events n = 6,017 | Validation cohort n = 226,140 Median follow-up 5 years (IQR, 3.27–5 years) Dementia events n = 1,699 | ||||
|---|---|---|---|---|---|---|
| Â | Obs | Mean | SD | Obs | Mean | SD |
Baseline age, years | 800,013 | 65.6 | 6.08 | 226,140 | 65.6 | 6.11 |
Baseline total cholesterol, mmol/L | 242,045 | 5.21 | 1.13 | 64,832 | 5.25 | 1.13 |
Baseline HDL cholesterol, mmol/L | 167,937 | 1.42 | 0.41 | 45,682 | 1.42 | 0.42 |
Baseline weight, kg | 226,671 | 79.2 | 16.9 | 59,594 | 79.1 | 16.8 |
Baseline systolic blood pressure, mmHg | 452,306 | 142.4 | 17.0 | 125,744 | 142.7 | 17.1 |
Height, m | 553,195 | 1.67 | 0.10 | 159,136 | 1.67 | 0.10 |
Baseline BMI, kg/m2 | 193,524 | 28.5 | 5.44 | 51,590 | 28.4 | 5.36 |
Baseline lipid ratio | 166,420 | 3.88 | 1.17 | 45,352 | 3.91 | 1.17 |
| Â | Obs | Freq | % | Obs | Freq | % |
Sex | 800,013 | Â | Â | 226,140 | Â | Â |
Men | Â | 386,039 | 48.3 | Â | 109,108 | 48.3 |
Women | Â | 413,974 | 51.8 | Â | 117,032 | 51.8 |
Local area deprivation score (quintiles) | 800,013 | Â | Â | 226,140 | Â | Â |
1 (=least deprived) | Â | 218,198 | 27.3 | Â | 71,040 | 31.4 |
2 | Â | 194,637 | 24.3 | Â | 57,763 | 25.5 |
3 | Â | 166,956 | 20.9 | Â | 42,278 | 18.7 |
4 | Â | 134,103 | 16.8 | Â | 33,945 | 15.0 |
5 (=most deprived) | Â | 86,119 | 10.8 | Â | 21,114 | 9.3 |
Baseline smoking status | 756,115 | Â | Â | 213,419 | Â | Â |
Never | Â | 323,345 | 42.8 | Â | 96,256 | 45.1 |
Past | Â | 286,763 | 37.9 | Â | 78,608 | 36.8 |
Current | Â | 146,007 | 19.3 | Â | 38,555 | 18.1 |
History of very heavy drinking/alcohol problem | 800,013 | 22,308 | 2.8 | 226,140 | 6,011 | 2.7 |
History of diabetes | 800,013 | 70,377 | 8.8 | 226,140 | 18,662 | 8.3 |
History of coronary heart disease | 800,013 | 93,408 | 11.7 | 226,140 | 26,016 | 11.5 |
History of stroke or transient ischemic attack | 800,013 | 38,976 | 4.9 | 226,140 | 10,930 | 4.8 |
History of atrial fibrillation | 800,013 | 24,763 | 3.1 | 226,140 | 7,085 | 3.1 |
Depression or use of anti-depressants at baseline | 800,013 | 83,464 | 10.4 | 226,140 | 23,583 | 10.4 |
Anxiety or use of anxiolytics at baseline | 800,013 | 29,690 | 3.7 | 226,140 | 8,549 | 3.8 |
Use of anti-hypertensive drugs at baseline | 800,013 | 274,657 | 34.3 | 226,140 | 75,359 | 33.3 |
Use of statins at baseline | 800,013 | 151,275 | 18.9 | 226,140 | 39,738 | 17.6 |
Use of hypnotics at baseline | 800,013 | 30,787 | 3.9 | 226,140 | 8,736 | 3.9 |
Use of NSAIDs (other than aspirin) at baseline | 800,013 | 98,397 | 12.3 | 226,140 | 27,546 | 12.2 |
Use of aspirin at baseline | 800,013 | 127,550 | 15.9 | 226,140 | 34,756 | 15.4 |