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Table 4 The risks of cancer related mortality by SF36 vitality score in the EPIC-Norfolk study

From: Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Mortality SF36 vitality score quartiles p valuea
76–100 65–75 50–64 0–49  
Model A: unadjusted full dataset
HR (95 % CI)
1 (reference) 0.97 (0.84–1.16) 1.16 (1.01–1.33) 1.10 (0.95–1.27) 0.043
Model B: unadjusted with removal of baseline CVD/cancer
HR (95 % CI)
1 (reference) 0.95 (0.82–1.10) 1.10 (0.95–1.28) 0.98 (0.83–1.15) 0.237
Model C: confounders
HR (95 % CI)
1 (reference) 0.96 (0.83–1.13) 1.14 (0.96–1.34) 1.09 (0.90–1.32) 0.185
Model D: confounders + Hb
HR (95 % CI)
1(reference) 0.94 (0.79–1.11) 1.16 (0.97–1.38) 1.12 (0.91–1.38) 0.086
Model E: confounders + TSH
HR (95 % CI)
1 (reference) 0.91 (0.75–1.10) 1.13 (0.93–1.38) 0.98 (0.77–1.24) 0.132
Model F: confounders + CRP
HR (95 % CI)
1 (reference) 1.06 (0.88–1.27) 1.18 (0.97–1.44) 1.09 (0.87–1.37) 0.385
Model G: confounders + Hb, CRP,TSH
HR (95 % CI)
1 (reference) 1.04 (0.84–1.29) 1.19 (0.95–1.51) 0.86 (0.65–1.15) 0.081
  1. aAcross quartiles
  2. Model A: unadjusted; Model B: unadjusted with removal of baseline CVD/cancer; Model C: Model B + statistically proven confounders – age, gender, body mass index, marital status, smoking, education, alcohol, social class, diet, physical activity, beta blocker, depression, pain, diabetes; Model D: Model C plus Hb adjusted; Model E: Model C plus TSH adjusted; Model F: Model C plus CRP adjusted; Model G: Model C plus Hb, CRP and TSH adjusted
  3. CI confidence interval, CRP C-reactive protein, CVD cardiovascular disease, Hb haemoglobin, HR hazard ratio, TSH thyroid-stimulting hormone