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Fig. 2 | BMC Medicine

Fig. 2

From: Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study

Fig. 2

Metabolic differences in first and third trimesters of pregnancy in urinary NMR spectral profiles. Principal component analysis (PCA) and orthogonal-projection to least squares-discriminant analysis (O-PLS-DA) models discriminating PCA score plots for the Sabadell (a) and Gipuzkoa subcohorts (b) at first (blue) and third trimesters (red). c O-PLS-DA loadings coefficient plot in the Sabadell subcohort. The height of spectral peaks represents the covariance, and the color code corresponds to the coefficient of determination, r2. Model statistics: R2Y = 0.88, R2X = 0.22, Q2Y = 0.84. d Same as (c) for Gipuzkoa subcohort, R2Y = 0.91, R2X = 0.13, Q2Y = 0.86. 4-DEA 4-deoxyerythronic acid, 4-DTA 4-deoxythreonic acid, Ala alanine, Lys lysine, NAC N-acetylneuraminic acid d, P3G, 5β-pregnane-3α,20α-diol-3α-glucuronide, Pn3-G, a progesterone metabolite (likely allopregnanolone and isomers)

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