Fig. 2From: Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA studyMetabolic differences in first and third trimesters of pregnancy in urinary NMR spectral profiles. Principal component analysis (PCA) and orthogonal-projection to least squares-discriminant analysis (O-PLS-DA) models discriminating PCA score plots for the Sabadell (a) and Gipuzkoa subcohorts (b) at first (blue) and third trimesters (red). c O-PLS-DA loadings coefficient plot in the Sabadell subcohort. The height of spectral peaks represents the covariance, and the color code corresponds to the coefficient of determination, r2. Model statistics: R2Y = 0.88, R2X = 0.22, Q2Y = 0.84. d Same as (c) for Gipuzkoa subcohort, R2Y = 0.91, R2X = 0.13, Q2Y = 0.86. 4-DEA 4-deoxyerythronic acid, 4-DTA 4-deoxythreonic acid, Ala alanine, Lys lysine, NAC N-acetylneuraminic acid d, P3G, 5β-pregnane-3α,20α-diol-3α-glucuronide, Pn3-G, a progesterone metabolite (likely allopregnanolone and isomers)Back to article page