Fig. 3
From: Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model
Heatmap of plasma metabolites significantly associated with free thyroxine (FT4) in mixed effect linear regression models. The first column displays the values of the mean false discovery rate (FDR) for the FT4 effect across 101 subsamples coded in grey color. The other columns indicate the mean log2-ratio from baseline (bas) compared to 4 (w4(T4)) and 8 (w8(T4)) weeks of treatment as well as 4 (w12) and 8 (w16) weeks after finishing the treatment. The time course of the FT4 concentrations is shown on top of the map as reference. Orange shading denotes an increase and blue shading a decrease compared to baseline, respectively. Derived physiological signatures are labeled on the left. The corresponding estimates and FDR values from regression analysis can be found in Additional file 2: Table S1. Metabolites marked with a star were assigned based on in silico fragmentation spectra