Fig. 2
Genetic influences on birth weight: Associations of child weight (a and b) and body mass index (c and d) at different time points with best-fit polygenic risk score (PRS). Best-fit PRS for Chinese, Malay and Indian ethnic groups used clumping P value thresholds pT = 0.5, 0.1 and 10–4, respectively. PRS was standardised to mean zero and unit variance within each ethnic group. Left panel (a and c) shows point estimates (height of bars) and 95% confidence intervals (top and bottom whiskers), for percentage change in child outcome, for a 2 SD increase in PRS, adjusted for child sex, gestational age and ethnicity. Analysis was done by linear regression of log-transformed child anthropometric outcome at each time point against PRS, adjusted for child sex, gestational age and ethnicity. Right panel (b and d) shows scatterplot of standardised (mean zero and unit variance) log-transformed child outcome (vertical axis) against PRS (horizontal axis)