Fig. 1

HRMAS NMR spectra of pancreatic healthy tissue (PP). a PP without neoadjuvant chemotherapy (n = 9), b PP with neoadjuvant chemotherapy (n = 8). The spectra metabolic contents are directly comparable because the intensity of each spectrum was normalized with respect to the weight of the analyzed sample. For display purposes, the amplitudes of the choline peak at 3.23 ppm, the glycine peak at 3.56 ppm, and the lactate peak at 1.33 ppm were graphically shortened. Metabolite assignments are given in Table 1