Table 1 Variant and effect allele with frequencies and magnitude of effect on each atopy-related trait and strength of association with glioma

Region

SNP

Position (bp)^a

Alleles^b

MAF

Hay fever and asthma

Glioma

OR (95% CI)

OR (95% CI)

 2q12.1

rs10197862

102,966,549

G/A

G = 0.161

1.24 (1.16–1.32)

0.98 (0.93−1.03)

 4p14

rs4833095

38,799,710

C/T

T = 0.425

1.20 (1.14–1.26)

1.03 (0.99−1.08)

 5q22.1

rs1837253

110,401,872

T/C

T = 0.382

1.17 (1.11–1.23)

0.96 (0.93−1.00)

 8q21.13

rs7009110

81,291,879

C/T

C = 0.467

1.14 (1.09–1.19)

0.98 (0.94−1.01)

 9p24.1

rs72699186

6,175,855

A/T

T = 0.110

1.26 (1.17–1.36)

0.97 (0.93−1.02)

 11q13.5

rs2155219

76,299,194

G/T

G = 0.468

1.17 (1.13–1.21)

1.01 (0.97−1.05)

 15q22.33

rs17294280

67,468,285

A/G

G = 0.120

1.18 (1.12–1.25)

0.98 (0.94−1.03)

 16p13.13

rs62026376

11,228,712

T/C

T = 0.144

1.17 (1.11–1.23)

0.97 (0.93−1.01)

 17q21.1

rs7212938

38,122,680

T/G

G = 0.473

1.16 (1.11–1.22)

1.00 (0.97−1.04)

Region

SNP

Position^a

Alleles^b

MAF

Atopic dermatitis

Glioma

OR (95% CI)

OR (95% CI)

 1q21.3

rs11205006

152,440,176

T/A

A = 0.265

1.62 (1.48–1.77)

0.96 (0.91−1.02)

 1q21.3

rs2228145

154,426,970

A/C

C = 0.293

1.15 (1.10–1.20)

0.99 (0.96−1.03)

 2p25.1

rs10199605

8,495,097

A/G

A = 0.244

1.04 (1.03–1.06)

1.01 (0.97−1.05)

 2p13.3

rs112111458

71,100,105

G/A

G = 0.224

1.08 (1.05–1.10)

0.98 (0.92−1.03)

 2q24.3

rs6720763

167,992,286

T/C

C = 0.320

1.29 (1.18–1.41)

1.02 (0.97−1.06)

 5p13.2

rs10214237

35,883,734

C/T

C = 0.176

1.06 (1.05–1.08)

0.98 (0.94−1.02)

 5q31.1

rs1295686

131,995,843

C/T

T = 0.422

1.35 (1.22–1.49)

0.99 (0.95−1.03)

 6p21.32

rs12153855

32,074,804

T/C

C = 0.125

1.58 (1.40–1.78)

0.97 (0.92−1.03)

 8q21.13

rs6473227

81,285,892

A/C

A = 0.473

1.06 (1.05–1.08)

0.98 (0.94−1.02)

 9p21.3

rs10738626

22,373,457

C/T

C = 0.397

1.23 (1.15–1.32)

0.96 (0.93−1.00)

 10p15.1

rs6602364

6,038,853

G/C

G = 0.492

1.05 (1.03–1.07)

1.03 (0.99−1.07)

 11q13.1

rs10791824

65,559,266

A/G

G = 0.490

1.15 (1.12–1.19)

0.99 (0.95−1.02)

 11q24.3

rs7127307

128,187,383

C/T

C = 0.488

1.09 (1.07–1.11)

0.99 (0.95−1.03)

 11q13.5

rs7130588

76,270,683

G/A

G = 0.216

1.29 (1.20–1.38)

1.02 (0.98−1.06)

 14q13.2

rs2143950

35,572,357

C/T

T = 0.215

1.08 (1.06–1.10)

1.01 (0.97−1.06)

 16p13.13

rs2041733

11,229,589

C/T

T = 0.496

1.09 (1.06–1.11)

0.97 (0.94−1.01)

 19p13.2

rs2164983

8,789,381

C/A

A = 0.169

1.16 (1.10–1.22)

0.95 (0.90−1.00)

 20q13.33

rs909341

62,328,742

T/C

T = 0.262

1.32 (1.21–1.44)

1.32 (1.26−1.37)

Region

SNP

Position^a

Alleles^b

MAF

IgE level^c

Glioma

OR (95% CI)

OR (95% CI)

 1q23.2

rs2251746

159,272,060

C/T

C = 0.015

1.09 (1.08–1.11)

0.98 (0.95−1.02)

 5q31.1

rs20541

131,995,964

A/G

A = 0.270

1.08 (1.06–1.10)

1.01 (0.97−1.06)

 6p22.1

rs2571391

29,923,838

C/A

C = 0.303

1.06 (1.05–1.08)

0.97 (0.94−1.01)

 6p21.32

rs2858331

32,681,277

A/G

G = 0.490

1.04 (1.03–1.06)

1.02 (0.98−1.06)

 12q13.3

rs1059513

57,489,709

C/T

C = 0.070

1.13 (1.09–1.17)

0.97 (0.92−1.03)

Region

SNP

Position^a

Alleles^b

MAF

Self–reported allergy

Glioma

OR (95% CI)

OR (95% CI)

 2q12.1

rs10189699

102,879,464

A/C

A = 0.143

1.16 (1.12–1.20)

0.99 (0.94−1.04)

 2q33.1

rs10497813

198,914,072

T/G

T = 0.401

1.08 (1.05–1.11)

0.99 (0.96−1.03)

 3q28

rs9860547

188,128,979

G/A

A = 0.272

1.08 (1.05–1.11)

1.02 (0.98−1.06)

 4p14

rs2101521

38,811,551

A/G

A = 0.475

1.15 (1.12–1.18)

1.02 (0.98−1.07)

 4q27

rs17388568

123,329,369

G/A

A = 0.141

1.08 (1.05–1.11)

1.01 (0.97−1.05)

 5p13.1

rs7720838

40,486,896

G/T

T = 0.362

1.08 (1.06–1.11)

1.02 (0.99−1.06)

 5q22.1

rs1438673

110,467,499

T/C

C = 0.296

1.12 (1.09–1.15)

0.97 (0.94−1.01)

 6p21.33

rs9266772

31,352,113

T/C

C = 0.175

1.11 (1.08–1.14)

1.03 (0.98−1.08)

 9p24.1

rs7032572

6,172,380

A/G

G = 0.114

1.12 (1.08–1.16)

0.97 (0.93−1.02)

 10p14

rs962993

9,053,132

T/C

T = 0.106

1.07 (1.05–1.10)

1.02 (0.98−1.06)

 11q13.5

rs2155219

76,999,194

G/T

G = 0.468

1.11 (1.09–1.14)

1.01 (0.97−1.05)

 15q22.33

rs17228058

67,450,305

A/G

G = 0.100

1.08 (1.05–1.11)

1.00 (0.96−1.04)

 17q21.1

rs9303280

38,074,031

T/C

T = 0.346

1.07 (1.05–1.09)

0.98 (0.94−1.02)

 20q13.2

rs6021270

50,141,264

C/T

T = 0.346

1.16 (1.10–1.22)

1.02 (0.94−1.10)