Impact of atopy on risk of glioma: a Mendelian randomisation study

Table 2 Inverse-variance weighting, maximum likelihood estimation, weighted median estimate, mode-based estimate and Mendelian randomisation-Egger test results for combined atopy-related instrumental variables

Trait	IVW		MLE		WME		MBE		MR-Egger slope		MR-Egger intercept
Trait	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	Estimate (95% CI)	P
Asthma and hay fever	0.96 (0.90–1.03)	0.248	0.96 (0.93–1.00)	0.066	0.93 (0.86–1.01)	0.087	0.91 (0.80–1.04)	0.191	0.99 (0.72–1.36)	0.951	−0.007 (−0.030 to 0.016)	0.542
Atopic dermatitis	0.96 (0.93–1.00)	0.041	0.96 (0.94–0.99)	0.003	0.96 (0.91–1.01)	0.114	0.97 (0.92–1.02)	0.194	0.97 (0.92–1.03)	0.375	0.004 (−0.014 to 0.006)	0.396
IgE level	0.88 (0.69–1.13)	0.319	0.88 (0.74–1.05)	0.157	0.83 (0.61–1.12)	0.218	0.82 (0.57–1.19)	0.355	0.63 (0.32–1.25)	0.184	0.027 (0.001 to 0.053)	0.042
Self-reported allergy	1.03 (0.95–1.11)	0.534	1.02 (0.97–1.08)	0.429	1.08 (0.97–1.20)	0.184	1.12 (0.92–1.36)	0.275	0.92 (0.69–1.22)	0.540	0.017 (0.003 to 0.031)	0.018

CI confidence interval, IVW inverse-variance weighting, MBE mode-based estimate, MLE maximum likelihood estimation, MR Mendelian randomisation, OR odds ratio, WME weighted median estimate

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