Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

Table 2 Cross-sectional associations of BMI with carotid intima-media thickness and pulse wave velocity with verbal memory, letter search speed, choice and simple reaction test at age 60–64 years

	MODEL 1		MODEL 2		MODEL 3
	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
VASCULAR MEASURES
1. cIMT (mm)	0.003 (0.0003 to 0.005)	0.025	0.002 (−0.0003 to 0.005)	0.085	0.003 (0.0004 to 0.006)	0.024
2. PWV (m/s)	0.040 (0.012 to 0.068)	0.005	0.018 (−0.009 to 0.045)	0. 192	0.014 (−0.015 to 0.043)	0.355
COGNITIVE MEASURES
1. VMT (n. of words)	–0.195 (−0.274 to −0.116)	< 0.001	−0.178 (−0.255 to −0.098)	< 0.001	−0.162 (−0.248 to −0.076)	< 0.001
2. LSST^a (targets)	–0.005 (−0.010 to −0.001)	0.018	−0.005 (−0.010 to −0.001)	0.027	−0.004 (−0.009 to 0.001)	0.117
3. RT (s)
a. Simple	0.485 (−0.373 to 1.344)	0.267	0.552 (−0.324 to 1.428)	0.217	0.689 (−0.300 to 1.679)	0.172
b. Choice	0.910 (−0.222 to 2.042)	0.115	0.983 (−0.157 to 2.123)	0.091	1.014 (−0.292 to 2.320)	0.128

Linear regression models were used to assess associations between variables
MODEL 1 adjusted for sex, education, childhood cognition; MODEL 2 = MODEL 1 + adjustments for socioeconomic position at age 53, systolic blood pressure and heart rate at age 60–64; MODEL 3 (fully adjusted) = MODEL 2 + adjustments for total cholesterol, smoking, diabetes and levels of physical activity. In each model, inverse probability weighting was implemented to account for the probability of survival until the end of follow-up
Numbers in italics indicate statistical significance
cIMT common carotid artery intima-media thickness, PWV pulse wave velocity, VMT verbal memory test, LSST letter search speed test, RT reaction time test
^aIndicates log transformed dependent variables

ISSN: 1741-7015