Table 1 Genetic risk burden of birthweight-reducing alleles in diverse populations
From: High burden of birthweight-lowering genetic variants in Africans and Asians
Population | N | Mean ± s.d. | Mean difference (95% CI); P value |
|---|---|---|---|
All SNPs (n = 59 SNPs) | |||
 AFR | 661 | 64.53 ± 4.21 | 3.15 (2.64, 3.66); <2 × 10− 16 |
 AMR | 347 | 64.40 ± 5.33 | 3.02 (2.34, 3.70); <2 × 10− 16 |
 EAS | 504 | 64.23 ± 4.34 | 2.85 (2.29, 3.41); <2 × 10− 16 |
 SAS | 489 | 62.45 ± 4.59 | 1.07 (0.49, 1.65); 0.0003 |
 EUR | 503 | 61.38 ± 4.66 | ref |
SNPs with ancestral birthweight-reducing alleles (n = 33 SNPs) | |||
 AFR | 661 | 48.85 ± 3.20 | 7.01 (6.63, 7.39); <2 × 10− 16 |
 AMR | 347 | 45.58 ± 4.01 | 3.74 (3.24, 4.24); <2 × 10− 16 |
 EAS | 504 | 45.07 ± 3.07 | 3.23 (2.83, 3.63); <2 × 10− 16 |
 SAS | 489 | 43.86 ± 3.37 | 2.02 (1.60, 2.44); <2 × 10− 16 |
 EUR | 503 | 41.84 ± 3.36 | ref |
SNPs with derived birthweight-reducing alleles (n = 26 SNPs) | |||
 AFR | 661 | 15.68 ± 2.90 | −3.85 (−4.20, −3.50); <2 × 10− 16 |
 AMR | 347 | 18.82 ± 3.16 | −0.70 (−1.14, −0.28); 0.0014 |
 EAS | 504 | 19.16 ± 3.06 | −0.37 (−0.76, 0.02); 0.0602 |
 SAS | 489 | 18.59 ± 3.02 | − 0.94 (−1.33, −0.55); 2.1 × 10− 06 |
 EUR | 503 | 19.53 ± 3.18 | ref |