High burden of birthweight-lowering genetic variants in Africans and Asians

Table 2 Genetic risk burden of birthweight-reducing alleles by deleteriousness score

Population^a	Relatively benign (n = 30 SNPs)		Relatively deleterious (n = 29 SNPs)
Population^a	Mean (s.d.)	Mean difference compared to EUR (95% CI); P value	Mean (s.d.)	Mean difference compared to EUR (95% CI); P value
AFR	29.85 (2.846)	1.98 (0.38, 3.58); 0.016	34.68 (3.109)	1.18 (−0.51, 2.87); 0.167
AMR	28.28 (3.449)	−0.41 (−1.35,2.17); 0.642	36.12 (3.768)	2.62 (0.76,4.48); 0.007
EAS	28.56 (3.127)	0.69 (−0.98,2.36); 0.412	35.66 (2.881)	2.16 (0.53, 3.79); 0.010
SAS	28.35 (3.332)	0.48 (−1.25,2.21); 0.579	34.10 (3.243)	0.60 (−1.12, 2.32); 0.488
EUR	27.87 (3.283)	ref	33.50 (3.360)	ref

^aFor each super-population, mean genetic risk burden of deleterious SNPs was significantly higher than that of benign SNPs. Mean differences: AFR (Africans) 4.83, AMR (admixed Americans) 7.84, EAS (East Asians) 7.1, SAS (South Asians) 5.75, EUR (Europeans) 5.63 (p < 0.001)
AFR Africans, AMR admixed Americans, CI confidence interval, EAS East Asians, EUR Europeans, ref reference, SAS South Asians, s.d. standard deviation, SNP single-nucleotide polymorphism

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