Fig. 1
From: Optimising trial designs to identify appropriate antibiotic treatment durations
Duration–response curves corresponding to an intention-to-treat analysis. Diamonds show hypothesised event rates for the two randomised groups as designed. The solid and dot-dashed lines show different hypothesised duration–response curves that are compatible with those hypothesised event rates. This figure illustrates that conventional randomised controlled trials that compare two different durations do not provide information about other durations, especially if one duration is clearly superior to the other