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Table 7 Empirical treatment recommendations for suspected bacterial meningitis

From: A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections

Initial treatment recommendations*

 CMG

3rd-generation cephalosporin (ceftriaxone^ or cefotaxime)

3rd generation-cephalosporin (ceftriaxone^ or cefotaxime) plus a penicillin (amoxicillin, ampicillin or penicillin)

Aminoglycoside (gentamicin) plus a penicillin (amoxicillin or ampicillin)

Add: glycopeptide (vancomycin)

Add: corticosteroids (before or with first dose of antibiotics)

 EFNS Europe

P, A

E

 

Older children and adults**

Yes

 ESCMID Europe

P, A

N, A > 50 years, or if risk factor for L. monocytogenes

N

**,^

Yes^ up to 4 h post-antibiotics

 DSI Denmark

A

A if risk of L. monocytogenes

  

Yes

 SPILF France

P, A

P, A if suspected L. monocytogenes°

 

If S. pneumoniae

Yes

 DGN: BM Germany

A

A

 

A**

Yes

 HPSC Ireland

P > 2 m, A

N, P < 2 months

N, P < 2 months

**,^

Yes up to 24 h post-antibiotics

 NVN Netherlands

P, A

N, A

  

Yes

 MHSSE# Spain

P

   

Yes

 NICE UK

P > 3 m

N, P < 3 months

 

If travel outside of the UK

Yes^^ up to 12 h post-antibiotics

 UKJSS UK

A

A > 60 years

 

Pending travel history

Yes up to 12 h post-antibiotics

 SIGN# Scotland

P > 3 m

N, P ≤ 3 months

  

Yes up to 24 h post-antibiotics

 IDSA USA/Global

P, A

N, A > 50 years

N

P, A

P^, infants if Hib, A

 AEPED Spain

P

N, P ≤ 3 months

 

**,^

Yes

 MSF Global

P > 3 m, A

N, P ≤ 3 months

N, P ≤ 3 months

 

Yes^

 NNF Norway

NS

NS

  

Yes

  1. The table shows empirical treatment recommendations for different risk groups
  2. *Initial recommendations to be reviewed as appropriate pending diagnostic results
  3. **If suspicion of reduced sensitivity to penicillin
  4. ^Not to neonates
  5. ^^Not to infants < 3 months
  6. Not to immunosuppressed
  7. #Focused on N. meningitidis only
  8. Abbreviations: N neonate, P paediatric populations, A adults, E elderly, NS non-specified population, EFNS European Federation of Neurological Societies, ESCMID European Society of Clinical Microbiology and Infectious Diseases, DSI Dansk Selskab for Infektionsmedicin, SPILF Société de Pathologie Infectieuse de Langue Française, DGN Deutsche Gesellschaft für Neurologie, BM Bakterielle Meningoenzephalitis, HPSC Health Protection Surveillance Centre, NVN Nederlandse Vereniging voor Neurologie, MHSSE Ministry of Health, Social Services and Equality, NICE The National Institute for Health and Care Excellence, UKJSS UK Joint Specialist Societies, SIGN Scottish Intercollegiate Guidelines Network, IDSA Infectious Diseases Society of America, AEPED Asociación Española de Pediatría, MSF Médecins Sans Frontières, NNF Norsk Nevrologisk Forening