Initial treatment recommendations* | |||||
---|---|---|---|---|---|
CMG | 3rd-generation cephalosporin (ceftriaxone^ or cefotaxime) | 3rd generation-cephalosporin (ceftriaxone^ or cefotaxime) plus a penicillin (amoxicillin, ampicillin or penicillin) | Aminoglycoside (gentamicin) plus a penicillin (amoxicillin or ampicillin) | Add: glycopeptide (vancomycin) | Add: corticosteroids (before or with first dose of antibiotics) |
EFNS Europe | P, A | E | Older children and adults** | Yes | |
ESCMID Europe | P, A | N, A > 50 years, or if risk factor for L. monocytogenes | N | **,^ | Yes^ up to 4 h post-antibiotics |
DSI Denmark | A | A if risk of L. monocytogenes | Yes | ||
SPILF France | P, A | P, A if suspected L. monocytogenes° | If S. pneumoniae | Yes″ | |
DGN: BM Germany | A | A | A** | Yes | |
HPSC Ireland | P > 2 m, A | N, P < 2 months | N, P < 2 months | **,^ | Yes up to 24 h post-antibiotics |
NVN Netherlands | P, A | N, A | Yes | ||
MHSSE# Spain | P | Yes | |||
NICE UK | P > 3 m | N, P < 3 months | If travel outside of the UK | Yes^^ up to 12 h post-antibiotics | |
UKJSS UK | A | A > 60 years | Pending travel history | Yes up to 12 h post-antibiotics | |
SIGN# Scotland | P > 3 m | N, P ≤ 3 months | Yes up to 24 h post-antibiotics | ||
IDSA USA/Global | P, A | N, A > 50 years | N | P, A | P^, infants if Hib, A |
AEPED Spain | P | N, P ≤ 3 months | **,^ | Yes | |
MSF Global | P > 3 m, A | N, P ≤ 3 months | N, P ≤ 3 months | Yes^ | |
NNF Norway | NS | NS | Yes |