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Fig. 1 | BMC Medicine

Fig. 1

From: Does low-density lipoprotein cholesterol induce inflammation? If so, does it matter? Current insights and future perspectives for novel therapies

Fig. 1

Inflammasomes are key signaling platforms that detect atherogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Inhibition of IL-1β/IL-6 signaling, which is initiated at the level of the nucleotide-binding leucine-rich repeat-containing pyrine receptor 3 (NLRP3) inflammasome, may therefore effectively reduce atherosclerotic CV outcomes. CRP C-reactive protein, LDL low-density lipoprotein, PAI-1 plasminogen activator inhibitor-1

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BMC Medicine

ISSN: 1741-7015

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