Fig. 7

Ionotropic glutamate receptor (iGluR) and Toll receptor signaling pathways play key role in TTC genes across white matter tracts. Pathway interactions unique to ROI pairs depending on tract connections were examined using chi-square tests. The pathway interactions with nominal significance (P < 0.05) are illustrated as network edges and were drawn for a tract-bound (G1) and b AD-tract-bound (G2). The nodes are 169 pathways, and they are differentially colored by Pathway Types. Node boundary is color labeled by Signaling Types. The graph was constructed by Spring-Affinity algorithm. c The nodal degrees in both graphs G1 (blue) and G2 (red) are ranked for 83 pathways notated in Fig. 6a. Degree for iGluR pathway (cyan circle) and Toll receptor signaling pathway (orange circle) is overlaid in the plot. d Fisher exact test results for symmetric gene synchronization of pathways across tract-bound ROI pairs (green circles) and AD-tract-bound ROI pairs (red circles) are visualized. The circles are molecular pathways and are organized by Signaling Types in the X-axis. The Y-axis shows P-values that are negative log₁₀ transformed. The TTC genes synchronized at the pathway level in both tract-bound and AD-associated tract-bound ROI pairs are indicated by arrows with pathway names. Orange dashed line delineates P-value = 0.05, and circles below this nominal significance were made partially transparent