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Table 5 Difference in longitudinal BMI change from baseline (age 1) stratified by PCOS phenotype

From: Updated adolescent diagnostic criteria for polycystic ovary syndrome: impact on prevalence and longitudinal body mass index trajectories from birth to adulthood

 

Original non-PCOS (n = 161)

OA + HA (updated PCOS) (n = 37)

HA + PCOM (n = 9)

OA + PCOM (n = 20)

∆BMI

95% CI

∆BMI

95% CI

p value*

∆BMI

95% CI

p value#

∆BMI

95% CI

p value$

Age 1

–

–

–

–

–

–

–

–

–

–

–

Age 2

− 1.31

− 2.14 to − 0.47

− 2.57

− 5.63 to 0.49

0.200

− 2.02

− 4.66 to 0.61

0.745

− 1.99

− 4.94 to 0.95

0.692

Age 3

− 0.93

− 1.49 to − 0.37

− 1.86

− 4.38 to 0.67

0.273

− 0.55

− 2.83 to 1.73

0.849

− 1.27

− 2.65 to 0.10

0.694

Age 5

− 1.21

− 1.72 to − 0.69

− 1.02

− 3.21 to 1.17

0.844

− 1.41

− 3.35 to 0.54

0.888

− 1.81

− 3.18 to 0.43

0.487

Age 8

− 0.18

− 0.70 to 0.34

0.32

− 1.81 to 2.45

0.531

0.37

− 1.57 to 2.31

0.704

− 1.17

− 2.57 to 0.23

0.263

Age 10

1.18

0.67 to 1.69

2.73

0.57 to 4.89

0.047

2.82

0.88 to 4.77

0.253

0.31

− 1.07 to 1.68

0.314

Age 14

4.24

3.73 to 4.75

7.51

5.38 to 9.64

< 0.001

5.69

3.75 to 7.64

0.312

3.61

2.24 to 4.99

0.471

Age 16

5.77

5.25 to 6.29

9.60

7.41 to 11.79

< 0.001

6.33

4.39 to 8.28

0.696

4.89

3.49 to 6.29

0.322

Age 20

6.85

6.33 to 7.37

10.20

7.97 to 12.42

< 0.001

6.95

5.00 to 8.89

0.946

5.41

4.01 to 6.81

0.097

Age 22

7.39

6.87 to 7.91

12.17

10.01 to 14.33

< 0.001

6.09

4.14 to 8.03

0.365

6.74

5.32 to 8.13

0.436

  1. Models were generated using generalized estimating equations and adjusted for age of menarche, family income at age 14, smoking status at age 22, and marital status at age 22
  2. ∆BMI mean BMI change, CI confidence interval, HA hyperandrogenism, OA oligo-anovulation, PCOM polycystic ovary morphology, PCOS polycystic ovary syndrome
  3. *p value for the interaction term phenotype OA + HA by age, comparing OA + HA with original non-PCOS
  4. #p value for the interaction term phenotype HA + PCOM by age, comparing HA + PCOM with original non-PCOS
  5. $p value for the interaction term phenotype OA + PCOM by age, comparing OA + PCOM with original non-PCOS