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Fig. 6 | BMC Medicine

Fig. 6

From: Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

Fig. 6

Mendelian randomization and age-, sex-, and BMI-adjusted multivariable regression analyses results for selected associations of total sleep duration with NMR-derived metabolomic measures. Figure shows inverse variance weighted (IVW) Mendelian randomization, Mendelian randomization sensitivity (weighted median (WM) and MR-Egger), and adjusted multivariable (AMV) regression analysis results. Results presented were selected on the basis of passing multiple testing threshold for either IVW or AMV (p values < 0.0029). The estimates are the difference in mean metabolite (in standard deviation units) per 1 h greater total sleep duration. Abbreviations: AMV, adjusted (age, sex, BMI) multivariable regression; BMI, body mass index; DHA, 22:6, docosahexaenoic acid; HDL, high-density lipoprotein; IVW MR, inverse variance weighted Mendelian randomization; NMR, nuclear magnetic resonance; SD, standard error; WM, weighted median

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BMC Medicine

ISSN: 1741-7015

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