Table 2 Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs associated with BF% and HF (Pmeta < 5 × 10− 8; single trait P < 0.05)
SNP | CHR | Position | Ref. allele | Alt. allele | PBF% | PHF | PMETA | Variant annotation | Genes within clumping region |
|---|---|---|---|---|---|---|---|---|---|
rs9937053 | 16 | 53799507 | G | A | 9.858E−26 | 2.992E−08 | 1.09E−18 | Intron | AKTIP,CHD9,FTO,FTO-IT1,LOC643802,LOC102723373,RBL2,RPGRIP1L |
rs1652348 | 18 | 21147509 | C | T | 0.0006127 | 2.477E−06 | 3.35E−08 | Intron | ANKRD29,C18orf8,CABLES1,LAMA3,LOC102724246,NPC1,RIOK3,TMEM241.TTC39C |
rs7234864 | 18 | 57734857 | C | T | 6.827E−07 | 1.804E−05 | 8.159E−09 | Regulatory region | CCBE1,MC4R,PMAIP1 |
rs10938397 | 4 | 45182527 | A | G | 1.359E−07 | 2.948E−06 | 4.36E−10 | Intergenic | GNPDA2,GUF1 |
rs10455872 | 6 | 161010118 | A | G | 0.02079 | 1.892E−11 | 3.879E−09 | Intron | IGF2R,LOC729603,LPA,LPAL2,MAP 3 K4,PLG,SLC22A1,SLC22A2,SLC22A3 |