Ischemic stroke, HR (95%CI) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Node1 | Node2 | Node3 | Node4 | Node5 | Node6 | Node7 | Node8 | Node9 | |
Case/person-years | 15/28,515 | 37/15,483 | 78/14,743 | 60/10,818 | 8/1026 | 119/12,021 | 10/547 | 53/2553 | 8/143 |
LDL-C ± SD, mg/dL | 56.8 ± 10.9 | 57.3 ± 10.8 | 64.6 ± 3.03 | 57.7 ± 8.76 | 55.6 ± 11.9 | 50.1 ± 6.48 | 19.2 ± 8.90 | 20.3 ± 8.53 | 20.6 ± 9.63 |
Multivariate modela | 1.00 (reference) | 3.73 (2.01, 6.92) | 7.07 (3.98, 12.6) | 7.38 (4.05, 13.4) | 8.44 (3.04, 23.4) | 13.0 (7.41, 22.7) | 20.8 (7.86, 54.8) | 23.1 (12.4, 43.1) | 76.3 (30.2, 192.7) |
Excluding eGFR < 60 ml/min/1.73 m2 | 1.00 (reference) | 3.60 (1.94, 6.70) | 6.06 (3.37, 10.9) | 7.10 (3.85, 13.1) | 8.86 (3.19, 24.6) | 12.8 (7.30, 22.4) | 18.9 (6.69, 53.4) | 24.6 (13.1, 46.2) | 62.2 (23.3, 166.3) |
Excluding Framingham risk score > 30% | 1.00 (reference) | 3.82 (2.02, 7.23) | 6.41 (3.38, 12.1) | 6.71 (3.29, 13.7) | 10.4 (3.74, 29.2) | 12.3 (6.74, 22.4) | 24.2 (6.74, 86.6) | 23.3 (11.2, 48.1) | 76.8 (24.7, 238.3) |
Excluding BMI < 18.5 kg/m2 | 1.00 (reference) | 3.75 (2.02, 6.94) | 7.01 (3.94, 12.5) | 7.51 (4.12, 13.7) | 8.37 (3.02, 23.2) | 13.0 (7.45, 22.8) | 21.9 (8.29, 57.9) | 23.1 (12.4, 43.1) | 74.5 (29.5, 188.2) |
Excluding blood pressure-lowering drugs | 1.00 (reference) | 3.48 (1.85, 6.56) | 6.49 (3.50, 12.0) | 7.24 (3.88, 13.5) | 9.26 (3.32, 25.8) | 11.0 (6.10, 19.8) | 22.0 (8.24, 59.0) | 22.3 (11.5, 43.2) | 52.1 (16.8, 161.5) |
Excluding glucose-lowering drugs | 1.00 (reference) | 3.69 (1.98, 6.87) | 6.92 (3.87, 12.4) | 7.81 (4.27, 14.3) | 9.35 (3.36, 26.0) | 13.1 (7.49, 23.0) | 18.0 (6.39, 50.7) | 21.8 (11.6, 40.9) | 63.1 (23.7, 168.0) |
Hemorrhagic stroke, HR (95%CI) | |||||||||
Node1 | Node2 | Node3 | Node4 | Node5 | Node6 | ||||
Case/person-years | 13/41,704 | 13/4435 | 19/10,553 | 75/27,377 | 12/2102 | 13/739 | |||
LDL-C ± SD, mg/dL | 59.3 ± 7.25 | 28.9 ± 9.75 | 58.8 ± 7.51 | 57.8 ± 8.82 | 19.9 ± 8.60 | 20.2 ± 8.03 | |||
Multivariate modela | 1.00 (reference) | 4.40 (2.07, 9.33) | 6.59 (3.55, 12.2) | 5.41 (2.22, 13.2) | 9.74 (3.84, 24.7) | 41.7 (17.2, 101.6) | |||
Excluding eGFR < 60 ml/min/1.73 m2 | 1.00 (reference) | 4.58 (2.13, 9.85) | 6.55 (3.52, 12.2) | 4.68 (1.84, 11.9) | 9.98 (3.78, 26.4) | 37.5 (15.3, 91.6) | |||
Excluding Framingham risk score > 30% | 1.00 (reference) | 5.09 (2.02, 12.8) | 5.01 (2.51, 9.99) | 4.11 (1.52, 11.1) | 10.7 (3.25, 35.2) | 21.3 (6.86, 65.9) | |||
Excluding BMI < 18.5 kg/m2 | 1.00 (reference) | 4.52 (2.13, 9.59) | 6.46 (3.48, 12.0) | 4.85 (1.91, 12.3) | 9.71 (3.82, 24.7) | 42.6 (17.4, 104.2) | |||
Excluding blood pressure-lowering drugs | 1.00 (reference) | 3.55 (1.57, 8.03) | 5.39 (2.78, 10.4) | 5.03 (2.05, 12.4) | 7.73 (2.60, 23.1) | 34.0 (12.8, 89.9) | |||
Excluding glucose-lowering drugs | 1.00 (reference) | 4.56 (2.14, 9.69) | 6.42 (3.44, 12.0) | 5.52 (2.26, 13.5) | 10.2 (4.00, 25.8) | 38.1 (15.2, 95.4) |