Fig. 2

Transient treatment with Nutlin-3 has a long-lasting rescue effect on cognitive deficits in FMR1-deficient mice. a Experimental scheme for analyzing cognitive performances in Fmr1 KO and WT mice treated with Nutlin-3 (Nut3) or vehicle (Veh). b Schematic of novel location recognition (NLR) test for assessing spatial learning. c Beneficial effects of Nutlin-3 treatment on spatial memory deficits in Fmr1 KO mice sustained at least 4 months after injection (n = 8 to 13 mice per group). d Schematic of the novel object recognition (NOR) test. e Therapeutic effects of Nutlin-3 treatment on deficits in the NOR test in Fmr1 KO mice last at least for 4 months after treatment cessation (n = 8 to 13 mice per group). *P < 0.05; **P < 0.01; ***P < 0.001. Data are presented as means ± SEM