Fig. 5

A graphical abstract for the major conclusions of the study. The immune microenvironmental features of GC stratified by CLDN18.2 indicated different therapeutic expectations to anti-PD-1/PD-L1 or CAR-T therapy. The blue area on the left represents the CLDN18.2-negative tumor microenvironment, where tumor cells expose few CLDN18.2 binding sites. The yellow area on the right represents the CLDN18.2-positive tumor microenvironment, where tumor cells expose more CLDN18.2 sites and CD8 + PD-1- T cells are enriched compared with CLDN18.2-negative gastric cancer