Overall (N = 694) | Women (N = 401) | Men (N = 293) | Psex | |
---|---|---|---|---|
Socio-demographic, lifestyle, and health-related factors at v1 | ||||
% men | 42.0 | – | – | – |
% African American | 55.8 | 54.6 | 57.3 | 0.48 |
Age at v1, years | 47.75 ± 0.34 | 47.94 ± 0.47 | 47.5 ± 0.5 | 0.52 |
% below poverty | 29.1 | 30.9 | 26.6 | 0.22 |
Education % | ||||
< High school | 5.5 | 5.3 | 5.7 | 0.91 |
High school | 57.1 | 56.7 | 57.8 | – |
> High school | 37.4 | 38.0 | 36.5 | 0.71 |
Current illicit drug use, % yes | 16.7 | 10.8 | 24.8 | < 0.001e |
Current tobacco use, % yes | 40.1 | 40.0 | 47.2 | 0.065e |
Healthy Eating Index, HEI-2010 total score | 42.3 ± 0.5 | 42.8 ± 0.6 | 41.6 ± 0.8 | 0.26 |
Energy intake, kcal/day | 1999 ± 46 | 1709 ± 49 | 2394 ± 71 | < 0.001e |
CES-D total score | 14.3 ± 0.4 | 14.9 ± 0.6 | 13.5 ± 0.6 | 0.11 |
Body mass index at v1, BMIv1, kg.m-2 | 30.3 ± 0.3 | 31.8 ± 0.4 | 28.2 ± 0.4 | < 0.001e |
Allostatic load total score at v1, ALtotal | 1.83 ± 0.04 | 1.86 ± 0.06 | 1.77 ± 0.07 | 0.36 |
Continuous componentsbof the allostatic load at v1, ALcomp_cont | ||||
Waist-to-hip ratio, WHR | 0.944 ± 0.019 | 0.935 ± 0.032 | 0.955 ± 0.005 | 0.60 |
Serum albumin, g/dl | 4.32 ± 0.01 | 4.27 ± 0.01 | 4.39 ± 0.02 | < 0.001e |
hsCRP, mg/L, Loge transformed | 0.738 ± 0.050 | 0.982 ± 0.064 | 0.401 ± 0.08 | < 0.001e |
Glycated hemoglobin, HbA1C, % | 5.84 ± 0.04 | 5.84 ± 0.05 | 5.84 ± 0.06 | 1.00 |
Total cholesterol, mg/dl | 186.6 ± 1.6 | 190.1 ± 2.03 | 181.8 ± 2.40 | 0.008e |
HDL cholesterol, mg/dl | 53.3 ± 0.6 | 55.8 ± 0.8 | 49.7 ± 1.0 | < 0.001e |
Resting heart rate, beat/min | 66.8 ± 0.5 | 67.3 ± 0.6 | 66.2 ± 0.7 | 0.26 |
Systolic blood pressure, mmHg | 119.1 ± 0.6 | 118.9 ± 0.9 | 119.4 ± 0.9 | 0.71 |
Diastolic blood pressure, mmHg | 72.8 ± 0.4 | 71.9 ± 0.5 | 74.2 ± 0.6 | 0.003e |
Binary componentsbof the allostatic load at v1, ALcomp_bin | ||||
Waist-to-hip ratio, WHR | 76.8 | 77.4 | 76.0 | 0.69 |
Serum albumin, g/dl | 2.2 | 3.0 | 1.0 | 0.093 |
hsCRP, mg/L | 41.7 | 50.5 | 29.6 | < 0.001e |
Glycated hemoglobin, HbA1C, % | 13.0 | 12.7 | 13.3 | 0.82 |
Total cholesterol, mg/dl | 9.4 | 9.7 | 8.9 | 0.70 |
HDL cholesterol, mg/dl | 19.0 | 13.0 | 27.0 | < 0.001e |
Resting heart rate, beat/min | 3.1 | 3.0 | 3.2 | 0.87 |
Systolic blood pressure, mmHg | 11.2 | 12.0 | 10.1 | 0.43 |
Diastolic blood pressure, mmHg | 6.5 | 4.8 | 8.7 | 0.045e |
Co-morbidityc | ||||
Diabetes status, % | ||||
No | 68.5 | 71.5 | 64.5 | – |
Pre-diabetes | 20.1 | 16.6 | 25.0 | 0.011e |
Diabetes | 11.3 | 11.9 | 10.5 | 0.069 |
Hypertension, % | 40.9 | 43.6 | 37.3 | 0.10 |
Dyslipidemia, % | 24.9 | 25.3 | 24.4 | 0.81 |
Cardiovascular disease, % | 12.8 | 15.9 | 8.7 | 0.007e |
Plasma NfL, Logetransformed | ||||
NfLv1 | 1.981 ± 0.019 | 1.948 ± 0.024 | 2.026 ± 0.031 | 0.045e |
NfLv2 | 2.179 ± 0.022 | 2.131 ± 0.027 | 2.245 ± 0.035 | 0.009e |
NfLv3 | 2.348 ± 0.022 | 2.298 ± 0.028 | 2.417 ± 0.036 | 0.008e |
δNfLd | 0.0479 ± 0.0004 | 0.0472 ± 0.0005 | 0.0487 ± 0.0007 | 0.083e |
All-cause deaths, % | 6.20 | 5.00 | 7.8 | 0.13 |