Plasma neurofilament light and its association with all-cause mortality risk among urban middle-aged men and women

Beydoun, May A.; Noren Hooten, Nicole; Weiss, Jordan; Beydoun, Hind A.; Hossain, Sharmin; Evans, Michele K.; Zonderman, Alan B.

doi:10.1186/s12916-022-02425-x

Table 2 Plasma NfL_v1 and δNfL and their relation to all-cause mortality by sex: Cox PH hazards models

From: Plasma neurofilament light and its association with all-cause mortality risk among urban middle-aged men and women

	Overall (N = 694), β ± SE^a	Women (N = 401), β ± SE	Men (N = 293), β ± SE	P_sex^b
NfLv1
Log_etransformed,z-score
Model 1^d	+ 0.275 ± 0.157, p = 0.080	+ 0.696 ± 0.247, p = 0.005	+ 0.060 ± 0.236, p = 0.80	0.018
Model 1^d	HR = 1.317	HR = 2.006	HR = 1.062	0.018
Model 2^d	+ 0.241 ± 0.170, p = 0.16	+ 0.557 ± 0.273, p = 0.041	+ 0.072 ± 0.257, p = 0.78	0.07
Model 2^d	HR = 1.273	HR = 1.745	HR = 1.075	0.07
Above vs. below median^e
Model 1^d	+ 0.177 ± 0.352, p = 0.61	+ 0.477 ± 0.527, p = 0.36	+ 0.104 ± 0.486, p = 0.83	0.34
Model 1^d	HR = 1.194	HR = 1.611	HR = 1.110	0.34
Model 2^d	0.095 ± 0.359, p = 0.79	+ 0.274 ± 0.566, p = 0.63	− 0.041 ± 0.509, p = 0.94	0.43
Model 2^d	HR = 1.010	HR = 1.315	HR = 0.956	0.43
δNfL^c
Log_etransformed,z-score
Model 1^d	+ 0.223 ± 0.141, p = 0.11	+ 0.436 ± 0.223, p = 0.051	+ 0.060 ± 0.197, p = 0.76	0.11
Model 1^d	HR = 1.250	HR = 1.547	HR = 1.062	0.11
Model 2^d	+ 0.201 ± 0.144, p = 0.16	+ 0.500 ± 0.235, p = 0.034	+ 0.047 ± 0.200, p = 0.81	0.092
Model 2^d	HR = 1.223	HR = 1.649	HR = 1.048	0.092
Above vs. below median^e
Model 1^d	+ 0.448 ± 0.346, p = 0.20	+ 1.363 ± 0.649, p = 0.036	− 0.194 ± 0.451, p = 0.67	0.015
Model 1^d	HR = 1.565	HR = 3.908	HR = 1.214	0.015
Model 2^d	+ 0.440 ± 0.351, p = 0.21	+ 1.595 ± 0.695, p = 0.022	− 0.266 ± 0.464, p = 0.57	0.011
Model 2^d	HR = 1.553	HR = 4.928	HR = 1.305	0.011

Abbreviations: Bayes empirical Bayes estimator, CES-D Center for Epidemiologic Studies-Depression, δ annualized rate of change, HANDLS Healthy Aging in Neighborhoods of Diversity Across the Life Span, HEI Healthy Eating Index, HR hazard ratio, NfL plasma neurofilament light, v₁ visit 1, v₂ visit 2, v₃ visit 3
^aValues are Log_e(HR) ± SE, p from Cox PH hazards models associated with each NfL exposure of interest. Hazard ratio (HR) point estimates are also presented. 95% CI for HR can be calculated as follows: lower confidence limit (LCL): exp[Log_eHR − 1.96×SE(Log_eHR)]; upper confidence limit (UCL): exp[Log_eHR + 1.96×SE(Log_eHR)]
^bP-value for the 2-way interaction term between plasma NfL exposure and sex in a separate unstratified model
^cAnnual rate of change in NfL between v₁ and v₃ using the empirical Bayes estimator predicted from a mixed-effects linear regression model with NfL as the outcome and TIME as the only predictor, validated against the observed annualized change between v₁ and v₃ (Pearson’s r > 0.80)
^dModel 1 adjusted for age at v1, sex, race, poverty status, and the inverse mills ratio; model 2 additionally adjusted for education, HEI-2010 total score, mean energy intake (kcal/day), current tobacco use, current illicit drug use, and the CES-D total score
^eSD values of continuous exposures can be derived from Table 1. Binary NfLv1 and δNfL (above vs. below or = median) based on distributions in the final selected sample with a cutoff of 1.966279 for NfL_v1 and 0.0466214 for δNfL

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ISSN: 1741-7015

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