Cohort analysis | Cousin analysis | Sibling analysis | ||||
---|---|---|---|---|---|---|
No type 1 diabetes | Type 1 diabetes | Not any diabetes | Type 1 diabetes | Not any diabetes | Type 1 diabetes | |
Overall | 2,976,704 (99.4) | 18,617 (0.6) | 21,036 (72.5) | 7988 (27.5) | 21,302 (59.9) | 14,284 (40.1) |
Boys | 1,529,498 (51.4) | 10,166 (54.6) | 10,729 (51.0) | 4399 (55.1) | 10,908 (51.2) | 7816 (54.7) |
Year of birth | ||||||
1983–1984 | 164,968 (5.5) | 888 (4.8) | 1141 (5.4) | 302 (3.8) | 799 (3.8) | 451 (3.2) |
1985–1989 | 469,384 (15.8) | 2811 (15.1) | 3800 (18.1) | 12,203 (15.1) | 3537 (16.6) | 2053 (14.4) |
1990–1994 | 534,392 (18.0) | 3892 (20.9) | 4918 (23.4) | 1849 (23.1) | 5038 (23.7) | 3236 (22.7) |
1995–1999 | 407,468 (13.7) | 3404 (18.3) | 3769 (17.9) | 1476 (18.5) | 4192 (19.7) | 2790 (19.5) |
2000–2004 | 421,330 (14.2) | 3533 (19.0) | 3436 (16.3) | 1531 (19.2) | 3782 (17.8) | 2842 (19.9) |
2005–2009 | 468,632 (15.7) | 2696 (14.5) | 2624 (12.5) | 1090 (13.6) | 2656 (12.5) | 2032 (14.2) |
2010–2014 | 510,530 (17.2) | 1393 (7.5) | 1348 (6.4) | 537 (6.7) | 1298 (6.1) | 80 (6.2) |
Gestational age in days, mean (SD) | 278.8 (12.2) | 277.9 (12.2) | 278.4 (12.4) | 278.0 (12.0) | 278.3 (12.0) | 278.0 (12.0) |
Birth weight for gestational age | ||||||
Small for gestational age | 70,763 (2.4) | 382 (2.1) | 466 (2.2) | 167 (2.1) | 388 (1.8) | 267 (1.9) |
Normal | 2,793,435 (93.8) | 17,350 (93.2) | 19,663 (93.5) | 7466 (93.5) | 19,783 (92.9) | 13,316 (93.2) |
Large for gestational age | 103,661 (3.5) | 834 (4.5) | 850 (4.0) | 337 (4.2) | 1066 (5.0) | 666 (4.7) |
Unknown | 8845 (0.3) | 51 (0.3) | 57 (0.3) | 18 (0.2) | 65 (0.3) | 35 (0.2) |
Birth order | ||||||
1 | 1,265,549 (42.5) | 7851 (42.2) | 8667 (41.2) | 3273 (41.0) | 7523 (35.3) | 5203 (36.4) |
2 | 1,082,395 (36.4) | 6833 (36.7) | 7545 (35.9) | 2966 (37.1) | 7617 (35.8) | 5796 (40.6) |
3 + | 628,760 (21.1) | 3933 (21.1) | 4824 (22.9) | 1749 (21.9) | 6162 (28.9) | 3285 (23.0) |
Maternal age at delivery in years, mean (SD) | 29.7 (5.2) | 29.7 (5.1) | 28.8 (5.1) | 29.4 (5.1) | 29.0 (5.1) | 29.5 (5.0) |
Maternal marital status | ||||||
Living with child’s father | 2,751,651 (92.4) | 17,282 (92.8) | 19,354 (92.0) | 7420 (92.9) | 19,788 (92.9) | 13,362 (93.5) |
Single | 56,402 (1.9) | 330 (1.8) | 452 (2.1) | 151 (1.9) | 347 (1.6) | 227 (1.6) |
Others | 89,494 (3.0) | 482 (2.6) | 641 (3.0) | 196 (2.5) | 553 (2.6) | 293 (2.1) |
Unknown | 79,157 (2.7) | 523 (2.8) | 589 (2.8) | 221 (2.8) | 614 (2.9) | 402 (2.8) |
Maternal educational level | ||||||
Pre-secondary | 386,663 (13.0) | 2343 (12.6) | 2799 (13.3) | 980 (12.3) | 2705 (12.7) | 1600 (11.2) |
Upper-secondary | 567,201 (19.1) | 4343 (23.3) | 5282 (25.1) | 2105 (26.4) | 5108 (24.0) | 3459 (24.2) |
High school | 567,452 (19.1) | 3573 (19.2) | 3684 (17.5) | 1495 (18.7) | 3764 (17.7) | 2736 (19.2) |
Post-secondary or higher | 914,211 (30.7) | 5387 (28.9) | 5018 (23.9) | 2127 (26.6) | 5547 (26.0) | 4198 (29.4) |
Unknown | 541,177 (18.2) | 2971 (16.0) | 4253 (20.2) | 1281 (16.0) | 4178 (19.6) | 2291 (16.0) |
Paternal educational level | ||||||
Pre-secondary | 492,235 (16.5) | 2975 (16.0) | 3597 (17.1) | 1258 (15.7) | 3213 (15.1) | 2098 (14.7) |
Upper-secondary | 716,097 (24.1) | 5451 (29.3) | 62,200 (29.5) | 2491 (31.2) | 6296 (29.6) | 4334 (30.3) |
High school | 547,304 (18.4) | 3226 (17.3) | 3287 (15.6) | 1344 (16.8) | 3312 (15.5) | 2372 (16.6) |
Post-secondary or higher | 785,763 (26.4) | 4607 (24.7) | 4347 (20.7) | 1828 (22.9) | 5002 (23.5) | 3645 (25.5) |
Unknown | 435,305 (14.6) | 2358 (12.7) | 3605 (17.1) | 1067 (13.4) | 3479 (16.3) | 1835 (12.8) |
Maternal BMI in kg/m2 during pregnancyb, mean (SD) | 23.9 (4.3) | 24.1 (4.3) | 23.9 (4.3) | 24.2 (4.3) | 24.1 (4.5) | 24.1 (4.3) |
Maternal cesarean section at delivery | 399,662 (13.4) | 2724 (14.6) | 2595 (12.3) | 1107 (13.9) | 2576 (12.1) | 1890 (13.2) |
Maternal diabetes at childbirthc | 24,923 (0.8) | 593 (3.2) | 340 (1.6) | 256 (3.2) | 560 (2.6) | 392 (2.7) |
Paternal diabetes at childbirth | 21,731 (0.7) | 865 (4.6) | 123 (0.6) | 371 (4.6) | 760 (3.6) | 623 (4.4) |
Maternal asthma at childbirth | 158,268 (5.3) | 1085 (5.8) | 1093 (5.2) | 475 (5.9) | 1141 (5.4) | 815 (5.7) |
Paternal asthma at childbirth | 35,258 (1.2) | 237 (1.3) | 202 (1.0) | 114 (1.4) | 259 (1.2) | 171 (1.2) |