Fig. 3

Proportion of CRP effect mediated by BMI, defining the CRP effect with two different instruments (45 CRP SNPs, rs2794520 (C \(\rightarrow\) T)) in the CRP region). Two methods of bootstrapping are used to estimate the uncertainty (Bayesian bootstrap, non-parametric bootstrap). CIDI, Composite International Diagnostic Interview; MDD, major depressive disorder; PHQ9, Patient Health Questionnaire-9; TRD, treatment-resistant depression