Table 2 Mean difference within-group and between-group during treatment intervals (ITT)

Necrosis (%)

 Baseline to day 2

 − 0.27 [− 0.38, − 0.15]^***

 − 0.12 [− 0.18, − 0.16]^***

 − 0.14

[− 0.28, − 0.01]

0.028

0.91 [0.54, 1.27]

 Baseline to day 4

 − 0.37 [− 0.49, − 0.25]^***

 − 0.21 [− 0.28, − 0.15]^***

 − 0.15

[− 0.28, 0.02]

0.023

0.73 [0.37, 1.08]

 Baseline to day 6

 − 0.39 [− 0.51, − 0.27]^***

 − 0.34 [− 0.40, − 0.28]^***

 − 0.05

[− 0.18, 0.08]

0.45

0.38 [− 0.12, 0.88]

Granulation (%)

 Baseline to day 2

0.30 [0.21, 0.39]^***

0.11 [0.03, 0.19]^***

0.18

[0.06, 0.31]

0.003

1.05 [0.68, 1.42]

 Baseline to day 4

0.49 [0.39, 0.59]^***

0.24 [0.16, 0.33]^***

0.24

[0.11, 0.37]

 < 0.001

1.06 [0.69, 1.43]

 Baseline to day 6

0.60 [0.51, 0.70]^***

0.34 [0.25, 0.43]^***

0.26

[0.13, 0.38]

 < 0.001

1.20 [− 0.12, 0.88]

Granulation/necrosis

 Baseline to day 2

5.01 [0.08, 9.94]^*

0.23 [− 0.47, 0.94]

4.77

[− 0.22, 9.77]

0.06

0.48 [− 0.08, 1.04]

 Baseline to day 4

15.5 [10.6, 20.5]^***

0.81 [0.10, 1.52]^*

14.7

[9.74, 19.73]

 < 0.001

1.37 [0.58, 2.13]

 Baseline to day 6

13.7 [8.8, 18.6]^***

1.43 [0.70, 2.16]^***

12.32

[7.28, 17.37]

 < 0.001

2.72 [1.72, 3.70]