Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses

Table 1 Genome-wide genetic correlation between gallstone disease and cardiovascular diseases

Models	Trait1	Trait2	\({{\varvec{r}}}_{{\varvec{g}}}\)	\({{\varvec{r}}}_{{\varvec{g}}}\_{\varvec{P}}\)	*gcov*	*gcov_se*
LDSC	GSD	Stroke	0.16	6.00 × 10^–4	0.011	0.005
LDSC	GSD	CAD	0.27	2.27 × 10^–15	0.012	0.007
GNOVA	GSD	Stroke	0.14	8.20 × 10^–6	0.009	0.002
GNOVA	GSD	CAD	0.27	7.89 × 10^–28	0.016	0.001

\({r}_{g}\) genetic correlation, GNOVA genetic covariance analyzer, LDSC linkage disequilibrium score regression, gcov genetic covariance, se standard error, GSD gallstone disease, CAD coronary artery disease

ISSN: 1741-7015