Exposure status | Cases/person-years | Model 1 | Model 2 | Model 3 | Sensitivity analysis |
---|
HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value |
---|
GSD → Stroke |
 No | 7,224/5,095,745 | 1.00 (ref) |  | 1.00 (ref) |  | 1.00 (ref) |  | 1.00 (ref) |  |
 Yes | 382/207,526 | 1.07 (0.97–1.19) | 0.18 | 0.97 (0.85–1.11) | 0.64 | 0.95 (0.83–1.09) | 0.46 | 1.19 (1.06–1.34) | 0.002 |
GSD → CAD |
 No | 24,709/4,810,395 | 1.00 (ref) |  | 1.00 (ref) |  | 1.00 (ref) |  | 1.00 (ref) |  |
 Yes | 1,254/184,808 | 1.27 (1.20–1.35) |  < 0.001 | 1.02 (0.95–1.10) | 0.54 | 0.98 (0.91–1.06) | 0.62 | 1.23 (1.15–1.31) |  < 0.001 |
- Model 1: adjusted for sex, age, assessment center, and the top 40 genetic principal components
- Model 2: adjusted for sex, age, assessment center, the top 40 genetic principal components, income, Townsend deprivation index, physical activity (IPAQ), smoking, drinking, sleep duration, dyslipidemia, hypertension, and waist-to-hip ratio (WHR)
- Model 3: adjusted for sex, age, assessment center, the top 40 genetic principal components, income, Townsend deprivation index, physical activity (IPAQ), smoking, drinking, sleep duration, dyslipidemia, hypertension, WHR, body mass index (BMI), Type 2 diabetes mellitus (T2DM)
- GSD gallstone disease, CAD coronary artery disease, HR Hazard ratio, CI Confidence interval