Table 3 Associations between total adherence score, categorised according to approximate score tertiles of the study population, and risk of all cancers combined and of cancers at individual anatomical sites

All cancers combined

93,630

7296

1.00 (ref)

0.91 (0.86; 0.97)

0.001^a

0.92 (0.87; 0.97)

0.83 (0.78; 0.87)

 < 0.001^a

0.84 (0.79; 0.89)

 < 0.001^a

Prostate

43,851

1818

1.00 (ref)

1.06 (0.95; 1.18)

0.275

1.06 (0.95; 1.18)

0.98 (0.87; 1.10)

0.686

0.96 (0.85; 1.08)

0.499

Breast

50,337

1438

1.00 (ref)

0.82 (0.72; 0.93)

0.003

0.82 (0.72; 0.94)

0.82 (0.73; 0.93)

0.001^a

0.82 (0.73; 0.93)

0.002^a

 Pre-menopausal

1108

154

1.00 (ref)

0.58 (0.38; 0.89)

0.013

0.58 (0.38; 0.89)

0.67 (0.47; 0.97)

0.032

0.67 (0.47; 0.96)

0.031

 Post-menopausal

49,229

1284

1.00 (ref)

0.83 (0.72; 0.96)

0.010

0.83 (0.72; 0.96)

0.81 (0.72; 0.93)

0.002^a

0.82 (0.72; 0.93)

0.002^a

Colorectal

94,656

862

1.00 (ref)

0.78 (0.66; 0.92)

0.004

0.79 (0.67; 0.93)

0.76 (0.65; 0.90)

0.001^a

0.79 (0.66; 0.93)

0.005

 Colon

94,698

575

1.00 (ref)

0.69 (0.56; 0.85)

 < 0.001^a

0.69 (0.57; 0.85)

0.67 (0.55; 0.82)

 < 0.001^a

0.69 (0.56; 0.84)

 < 0.001^a

 Distal

94,734

242

1.00 (ref)

0.62 (0.46; 0.86)

0.003

0.62 (0.45; 0.85)

0.54 (0.39; 0.76)

 < 0.001^a

0.56 (0.40; 0.77)

 < 0.001^a

 Proximal

94,748

303

1.00 (ref)

0.77 (0.58; 1.02)

0.069

0.78 (0.59; 1.03)

0.75 (0.57; 1.00)

0.057

0.77 (0.58; 1.02)

0.067

 Rectum

94,734

342

1.00 (ref)

0.97 (0.74; 1.25)

0.789

0.99 (0.76; 1.28)

0.97 (0.74; 1.26)

0.798

1.01 (0.78; 1.32)

0.926

Lung

94,760

431

1.00 (ref)

0.92 (0.73; 1.15)

0.465

1.02 (0.81; 1.27)

0.67 (0.52; 0.85)

0.001^a

0.80 (0.63; 1.02)

0.073

Kidney

94,754

221

1.00 (ref)

0.85 (0.62; 1.16)

0.299

0.85 (0.62; 1.17)

0.64 (0.45; 0.90)

0.011

0.64 (0.45; 0.92)

0.014

Pancreas

94,770

213

1.00 (ref)

0.72 (0.52; 1.01)

0.061

0.74 (0.53; 1.04)

0.73 (0.52; 1.01)

0.058

0.75 (0.53; 1.04)

0.087

Uterus

50,588

212

1.00 (ref)

1.00 (0.71; 1.40)

0.994

0.99 (0.71; 1.39)

0.84 (0.61; 1.16)

0.287

0.83 (0.60; 1.14)

0.250

Oesophagus

94,765

151

1.00 (ref)

0.89 (0.61; 1.29)

0.534

0.92 (0.63; 1.34)

0.60 (0.39; 0.92)

0.020

0.64 (0.41; 0.99)

0.046

Ovary

50,603

147

1.00 (ref)

0.69 (0.46; 1.03)

0.071

0.69 (0.46; 1.03)

0.57 (0.39; 0.84)

0.005

0.57 (0.39; 0.84)

0.005

Bladder

94,756

141

1.00 (ref)

0.70 (0.47; 1.06)

0.093

0.73 (0.48; 1.10)

0.67 (0.43; 1.03)

0.066

0.72 (0.47; 1.11)

0.137

Head and Neck

94,763

129

1.00 (ref)

1.45 (0.95; 2.22)

0.086

1.51 (0.98; 2.31)

1.42 (0.93; 2.18)

0.108

1.52 (0.99; 2.33)

0.057

Stomach

94,770

99

1.00 (ref)

1.01 (0.63; 1.62)

0.982

1.02 (0.64; 1.65)

0.94 (0.57; 1.54)

0.804

0.97 (0.59; 1.59)

0.899

Liver

94,773

82

1.00 (ref)

0.78 (0.46; 1.33)

0.364

0.80 (0.47; 1.35)

0.66 (0.38; 1.15)

0.142

0.68 (0.39; 1.18)

0.172

Gallbladder

94,777

49

1.00 (ref)

0.68 (0.34; 1.35)

0.269

0.67 (0.34; 1.33)

0.56 (0.27; 1.15)

0.115

0.54 (0.26; 1.12)

0.098