| EPIC | UKB |
---|
N at risk / N cases | HR (95% CI) | p2 | p3 | p4 | N at risk / N cases | HR (95% CI) | p2 | p3 | p4 |
---|
Obesity-related cancers |
 Base model5 | 233,249 / 7,892 | 1.10 (1.08; 1.12) |  < 0.001 |  |  | 344,094 / 12,526 | 1.16 (1.14; 1.18) |  < 0.001 |  |  |
 Overall adj. model6 | 233,249 / 7,892 | 1.09 (1.07; 1.11) |  < 0.001 |  |  | 344,094 / 12,526 | 1.14 (1.12; 1.16) |  < 0.001 |  |  |
 Without CMD7,8 | 233,249 / 7,382 | 1.09 (1.07; 1.11) |  < 0.001 |  | 0.95 | 344,094 / 1,354 | 1.14 (1.12; 1.16) |  < 0.001 |  | 0.52 |
 T2D7 | 9,961 / 311 | 1.11 (1.03; 1.19) | 0.005 | 0.75 |  | 14,149 / 291 | 1.12 (1.03; 1.22) |  < 0.001 | 0.68 |  |
 CVD7 | 8,746 / 168 | 1.11 (0.98; 1.24) | 0.09 | 0.84 |  | 29,778 / 813 | 1.19 (1.12; 1.25) |  < 0.001 | 0.17 |  |
 T2D-CVD7 | 940 / 31 | 1.03 (0.79; 1.35) | 0.81 | 0.67 |  | 2,464 / 68 | 1.11 (0.94;1.31) | 0.23 | 0.74 |  |
- Abbreviations: SD standard deviation, BMI body mass index, HR hazard ratio, 95%CI 95% confidence intervals, T2D type 2 diabetes, CVD cardiovascular diseases, CMD cardiometabolic diseases, EPIC European Prospective Investigation into Cancer and nutrition, UKB UK Biobank
- 1Standard deviation (SD) of BMI in EPIC = 4.18 kg/m2; Standard deviation (SD) of BMI in UKB = 4.60 kg/m2
- P-values:Â 2Â p-values for association of local association tests;3Â p-values for the individual interaction term;Â 4Â p-value from likelihood ratio test comparing models with and without an interaction term
- 5Base model adjusted for educational level, alcohol consumption, smoking status, height, physical activity, healthy diet score, menopausal status for women, use of HRT for women, and stratified by centre of recruitment, age (5-year categories), and sex
- 6Overall adjusted model (further adjusted for CMD, modelled as a time-varying variable, and the duration of these comorbidities)
- 7Overall adjusted model with an interaction term between BMI and CMD (modelled as a time-varying variable)
- 8Without CVD and T2D