| EPIC | UKB | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
T2D | CVD | T2D and CVD | T2D | CVD | T2D and CVD | |||||||
N at risk / N cases | HR (95% CI) | N at risk / N cases | HR (95% CI) | N at risk / N cases | HR (95% CI) | N at risk / N cases | HR (95% CI) | N at risk / N cases | HR (95% CI) | N at risk / N cases | HR (95% CI) | |
BMI < 25 kg/m2, without CMD of interesta | 100,714 / 3,150 | 1.00 (ref) | 99,096 / 3,127 | 1.00 (ref) | 101,886 / 3,185 | 1.00 (ref) | 177,892 / 3,859 | 1.00 (ref) | 111,433 / 3,685 | 1.00 (ref) | 118,934 / 3,878 | 1.00 (ref) |
BMI < 25 kg/m2, with CMD | 1,296 / 38 | 1.87 (1.25; 2.81) | 2,914/61 | 1.47 (0.98; 2.19) | 124 / 3 | 2.09 (0.58; 7.48) | 1,257 / 24 | 2.28 (1.44; 3.60) | 7,716 / 188 | 2.68 (2.23; 3.23) | 215 /5 | 6.45 (2.58; 16.16) |
BMI ≥ 25 kg/m2, without CMD of interest | 122,574 / 4,431 | 1.12 (1.07; 1.17) | 125,407 / 4,597 | 1.12 (1.07; 1.18) | 130,423 / 4,676 | 1.12 (1.07; 1.17) | 213,352 / 8,376 | 1.23 (1.18; 1.28) | 204,048 / 8,018 | 1.23 (1.18; 1.28) | 222,696 / 8,580 | 1.23 (1.18; 1.28) |
BMI ≥ 25 kg/m2, with CMD (joint effect) | 8,665 / 273 | 2.23 (1.68; 2.95) | 5,832 / 107 | 1.47 (0.98; 2.13) | 816 / 28 | 2.35 (1.25; 4.44) | 11,593 / 267 | 2.90 (2.25; 3.74) | 20,897 / 625 | 3.41 (2.95; 3.95) | 2,249 / 63 | 7.93 (5.49; 11.44) |
RERI | Â | 0.24 (-0.43; 0.63) | Â | -0.12 (-0.59; 0.35) | Â | 0.14 (-2.54; 2.83) | Â | 0.39 (-0.59; 1.38) | Â | 0.50 (0.02; 0.98) | Â | 1.24 (-4.79; 7.27) |
BMI < 30 kg/m2, without CMD of interesta | 191,346 / 6,252 | 1.00 (ref) | 189,779 / 6,279 | 1.00 (ref) | 196,344 / 6,399 | 1.00 (ref) | 261,442 / 9,150 | 1.00 (ref) | 246,173 / 8,730 | 1.00 (ref) | 266,132 / 9,249 | 1.00 (ref) |
BMI < 30 kg/m2, with CMD | 5,542 / 164 | 2.28 (1.81; 2.88) | 7,109 / 137 | 1.48 (1.09; 2.01) | 544 / 17 | 2.93 (1.72; 5.00) | 5,771 / 127 | 2.44 (1.84; 3.23) | 21,040 / 547 | 2.69 (2.32; 3.10) | 1,081 /28 | 7.14 (4.53; 11 27) |
BMI ≥ 30 kg/m2, without CMD of interest | 31,942 / 1,329 | 1.19 (1.12; 1.26) | 34,724 / 1,445 | 1.18 (1.11; 1.24) | 35,965 / 1,462 | 1.18 (1.11; 1.24) | 69,802 / 3,085 | 1.24 (1.19; 1.30) | 69,308 / 2,983 | 1.23 (1.18; 1.29) | 75,498 / 3,209 | 1.24 (1.19; 1.29) |
BMI ≥ 30 kg/m2, with CMD (joint effect) | 4,419 / 147 | 2.44 (1.91; 3.12) | 1,637 / 31 | 1.74 (1.15; 2.61) | 396 / 14 | 1.17 (1.11; 1.24) | 7,076 / 164 | 2.73 (2.09; 3.57) | 7,573 / 266 | 3.58 (3.02; 4.24) | 1,383 / 40 | 7.05 (4.66; 10.66) |
RERI | Â | -0.03 (-0.49; 0.43) | Â | 0.08 (-0.52; 0.68) | Â | 0.81 (-1.12; 2.75) | Â | 0.05 (-0.55; 0.65) | Â | 0.66 (0.16; 1.17) | Â | -0.33 (-3.77; 3.11) |