PK parameters | 30 mg N = 8 | 40 mg N = 8 |
---|---|---|
Tmax,ss (h) | 0.62 (0.33–1.00) | 0.88 (0.50–4.00) |
T1/2,ss (h) | 7.24 ± 1.35 (18.69) | 8.50 ± 1.63 (19.15) |
Cmax,ss (ng/mL) | 1127.38 ± 205.57 (18.23) | 1528.75 ± 320.96 (20.99) |
Cavg,ss (ng/mL) | 478.59 ± 100.65 (21.03) | 782.98 ± 127.79 (16.32) |
Cmin,ss (ng/mL) | 204.88 ± 73.91 (36.08) | 449.63 ± 85.91 (19.11) |
AUC0-τ,ss (h*ng/mL) | 5743.12 ± 1207.85 (21.03) | 9395.79 ± 1533.46 (16.32) |
AUC0-48 h,ss (h*ng/mL) | 8282.70 ± 2266.75 (27.37) | 14,737.31 ± 3178.18 (21.57) |
AUC0-∞,ss (h*ng/mL) | 8377.29 ± 2338.26 (27.91) | 15,061.14 ± 3425.91 (22.75) |
CL/F,ss (mL/h) | 5444.94 ± 1210.19 (22.23) | 4353.55 ± 679.42 (15.61) |
Vd/F,ss (mL) | 55,625.89 ± 10,662.74 (19.17) | 52,688.80 ± 9545.88 (18.12) |
Rac,ss (%) | 1.36 ± 0.24 (17.81) | 1.68 ± 0.19 (11.12) |
DF (%) | 198.09 ± 50.69 (25.59) | 137.29 ± 23.01 (16.76) |