Table 4 Results of the sensitivity analysis with varying definitions of cardiovascular drug adherence and AET discontinuation

Varying PDC thresholds for adherence

 Global cardiovascular adherence (PDC ≥ 0.7)

  Full adherence

Ref

Ref

  Partial adherence

1.16 [1.11; 1.22] ***

1.16 [1.10; 1.21] ***

  Full non-adherence

1.58 [1.46; 1.71] ***

1.57 [1.44; 1.70] ***

 Global cardiovascular adherence (PDC ≥ 0.9)

  Full adherence

Ref

Ref

  Partial adherence

1.12 [1.05; 1.20]***

1.12 [1.05; 1.19]***

  Full non-adherence

1.37 [1.29; 1.45]***

1.36 [1.28; 1.45]***

Discontinuation = at least 60 days without any available AET pill

 Global cardiovascular adherence (pdc ≥ 0.8)

  Full adherence

Ref

Ref

  Partial adherence

1.15 [1.10; 1.20]***

1.14 [1.09; 1.20]***

  Full non-adherence

1.53 [1.45; 1.62]***

1.52 [1.43; 1.61]***

Discontinuation = at least 120 days without any available AET pill

 Global cardiovascular adherence (PDC ≥ 0.8)

  Full adherence

Ref

Ref

  Partial adherence

1.14 [1.09; 1.21]***

1.14 [1.08; 1.20]***

  Full non-adherence

1.44 [1.35; 1.54]***

1.43 [1.33; 1.53]***