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Fig. 7 | BMC Medicine

Fig. 7

From: Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction

Fig. 7

Schematic representation of RNase T2 function in sperm maturation and intergenerational inheritance. Increased expression of RNase T2 in caput epididymis, induced by environmental stressors, contributes to severe astheno-teratozoospermia in males and furthermore leads to metabolic disorders in the offspring. Both proteins and sncRNAs undergo transfer from the epididymal epithelial cells to maturing sperm through delivery by exosomes. These factors thereby contribute to regulation of sperm function and sncRNAs composition

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BMC Medicine

ISSN: 1741-7015

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