Table 2 Multiple linear regression analysis of the relationship between placental cytokine mRNA expression and children’s cognitive performance
Cytokines | Participants | VCI | VSI | FRI | WMI | PSI | FSIQ |
|---|---|---|---|---|---|---|---|
Adjusted β (95%CI) | |||||||
IL-8 | |||||||
Totala | -0.39(-0.82,0.04) | -0.57(-1.01,-0.13)* | -0.63(-1.05,-0.21)**★ | -0.36(-0.77,0.06) | -0.38(-0.79,0.03) | -0.53(-0.92,-0.15)**★ | |
Boysb | -0.29(-0.95,0.36) | -0.97(-1.64,-0.31)**★ | -0.65(-1.27,-0.03)* | -0.75(-1.37,-0.14)*★ | -0.64(-1.23,-0.05)* | -0.77(-1.35,-0.18)* | |
Girlsb | -0.49(-1.05,0.07) | -0.26(-0.85,0.33) | -0.67(-1.24,-0.10)* | -0.05(-0.61,0.51) | -0.16(-0.73,0.41) | -0.37(-0.86,0.12) | |
IL-1β | |||||||
Totala | 0.16(-0.25,0.57) | 0.01(-0.42,0.44) | -0.08(-0.48,0.33) | -0.03(-0.42,0.37) | -0.06(-0.45,0.33) | -0.01(-0.37,0.36) | |
Boysb | 0.10(-0.52,0.71) | 0.14(-0.48,0.76) | -0.17(-0.74,0.40) | -0.25(-0.82,0.33) | 0.01(-0.53,0.56) | -0.05(-0.60,0.50) | |
Girlsb | 0.22(-0.34,0.77) | -0.15(-0.74,0.43) | -0.01(-0.58,0.56) | 0.14(-0.41,0.70) | -0.14(-0.71,0.42) | 0.00(-0.487,0.486) | |
IL-6 | |||||||
Totala | -0.42(-0.86,0.02) | -0.29(-0.74,0.17) | -0.54(-0.97,-0.11)*★ | -0.48(-0.91,-0.05)* | -0.46(-0.88,-0.04)* | -0.58(-0.97,-0.19)**★ | |
Boysb | 0.02(-0.65,0.69) | -0.68(-1.36,0.00)* | -0.81(-1.44,-0.18)* | -0.83(-1.45,-0.20)**★ | -0.45(-1.06,0.15) | -0.61(-1.20,-0.01)* | |
Girlsb | -0.86(-1.44,-0.28)**★ | 0.03(-0.58,0.65) | -0.30(-0.89,0.29) | -0.13(-0.71,0.46) | -0.46(-1.05,0.12) | -0.58(-1.09,-0.07)* | |
TNF-α | |||||||
Totala | -0.44(-0.82,-0.05)* | -0.13(-0.54,0.28) | -0.25(-0.62,0.13) | -0.39(-0.76,-0.01)* | -0.25(-0.61,0.12) | -0.37(-0.71,-0.02)*★ | |
Boysb | -0.04(-0.63,0.55) | -0.08(-0.68,0.52) | 0.09(-0.46,0.63) | -0.56(-1.11,-0.01)* | -0.18(-0.71,0.34) | -0.20(-0.72,0.33) | |
Girlsb | -0.84(-1.34,-0.33)**★ | -0.23(-0.76,0.31) | -0.56(-1.08,-0.05)* | -0.20(-0.71,0.32) | -0.31(-0.82,0.21) | -0.55(-1.00,-0.10)* | |
CRP | |||||||
Totala | -0.05(-0.31,0.22) | -0.08(-0.35,0.19) | 0.09(-0.18,0.35) | 0.12(-0.14,0.37) | 0.03(-0.22,0.28) | -0.06(-0.29,0.18) | |
Boysb | -0.24(-0.63,0.15) | -0.07(-0.46,0.33) | -0.03(-0.40,0.34) | -0.06(-0.42,0.31) | -0.31(-0.66,0.04) | -0.24(-0.59,0.10) | |
Girlsb | 0.15(-0.20,0.51) | -0.06(-0.44,0.31) | 0.26(-0.11,0.63) | 0.32(-0.04,0.68) | 0.46(0.10,0.83)* | 0.16(-0.16,0.47) | |
IFN-γ | |||||||
Totala | -0.17(-0.50,0.16) | -0.35(-0.69,-0.01)* | -0.22(-0.54,0.11) | -0.44(-0.75,-0.12)**★ | -0.32(-0.63,0.00)* | -0.31(-0.61,-0.03)*★ | |
Boysb | -0.04(-0.53,0.45) | -0.25(-0.74,0.25) | -0.09(-0.55,0.38) | -0.57(-1.03,-0.11)*★ | -0.46(-0.90,-0.01)* | -0.37(-0.80,0.07) | |
Girlsb | -0.30(-0.74,0.14) | -0.46(-0.93,0.01) | -0.35(-0.80,0.10) | -0.30(-0.75,0.14) | -0.16(-0.61,0.29) | -0.28(-0.67,0.11) | |
IL-4 | |||||||
Totala | -0.15(-0.54,0.23) | -0.16(-0.55,0.24) | -0.07(-0.45,0.31) | -0.18(-0.55,0.19) | -0.06(-0.42,0.31) | -0.18(-0.52,0.16) | |
Boysb | -0.03(-0.61,0.55) | -0.15(-0.73,0.44) | 0.19(-0.35,0.74) | -0.31(-0.85,0.24) | -0.01(-0.53,0.51) | -0.22(-0.74,0.30) | |
Girlsb | -0.27(-0.77,0.23) | -0.16(-0.69,0.37) | -0.30(-0.83,0.23) | -0.04(-0.55,0.47) | -0.07(-0.59,0.46) | -0.12(-0.57,0.32) | |
IL-10 | |||||||
Totala | -0.04(-0.42,0.33) | -0.24(-0.63,0.15) | -0.32(-0.69,0.05) | -0.05(-0.42,0.32) | 0.16(-0.20,0.52) | -0.22(-0.56,0.11) | |
Boysb | -0.05(-0.61,0.51) | -0.25(-0.82,0.31) | -0.56(-1.09,-0.04)* | -0.32(-0.84,0.21) | -0.51(-0.55,0.45) | -0.39(-0.89,0.14) | |
Girlsb | -0.06(-0.56,0.44) | -0.23(-0.76,0.30) | -0.02(-0.55,0.51) | 0.24(-0.27,0.75) | 0.38(-0.14,0.91) | -0.06(-0.50,0.39) | |